ZIC4 Antibody
- Known as:
- ZIC4 Antibody
- Catalog number:
- TRA-084107-M09
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- ZIC4 Antibody
Related genes to: ZIC4 Antibody
- Gene:
- ZIC4 NIH gene
- Name:
- Zic family member 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-03
- Date modifiied:
- 2013-01-08
Related products to: ZIC4 Antibody
Related articles to: ZIC4 Antibody
- - Source: PubMed
Publication date: 2026/05/26
González Isabel RosChavarría-Miranda AlbaFolgueral Carolina GonzálezHueso María Pedraza - ZIC1 encodes a transcription factor with critical roles in vertebrate neural and skeletal development. Heterozygous deletions encompassing ZIC1 and ZIC4 cause Dandy-Walker malformation, whilst in the final exon heterozygous ZIC1 variants result in a distinct phenotype of craniosynostosis with variable intellectual disability via a gain-of-function mechanism. We describe the largest group of individuals harboring ZIC1 variants to date, significantly expanding the phenotypic spectrum and allowing genotype-phenotype correlation. - Source: PubMed
Publication date: 2026/04/22
Watts Laura MChang Michelle S MLewis-Orr ElizabethWalton Isaac SLeinhos LisaTooze Rebecca SPei YangCalpena EduardoVedovato-Dos-Santos J HeatherSteel DoraReid Kimberley MKurian Manju AMohammad Shekeeb SCantagrel VincentSiquier KarineBoddaert NathalieRio MarleneBlyth MoiraKraus AlisonAl Mutairi FuadHolder Susan EClowes Virginia ECobben Jan MTimberlake Andrew TElias Ellen RStewart HelenJohnson DianaCohen Julie SBarañano Kristin WCeulemans SophiaJones Marilyn COrtega Rico Rita IHaug Marte GBerland SirenBombei Hannah MPaulson AnnaSidhu AlpaGooch Catherine Fda Rocha Kátia MPassos Bueno Maria RitaŢopa AlexandraMuslimovic Aida ZMaltese GiovanniTan Tiong YangMcCann EmmaLord HelenChin Hui-LinLin JeremyLi-Meng Goh DeniseKeren BorisCharles PerrineDelchev TrayanAvdjieva-Tzavella DanielaAlawbathani SalemAlmeida LigiaKdissa AmeniAl-Ali RuslanBertoli-Avella Aida MJohnson DavidWilkie Andrew O MArkell Ruth MShears Deborah JTwigg Stephen R F - Copy number variants (CNVs) are large-scale genomic alterations that contribute substantially to genetic diversity and may influence phenotypic variation in livestock. This study investigated the genome-wide CNV landscape of three Vietnamese indigenous chicken breeds. Whole-genome sequencing on the Illumina platform (3-5× coverage) was performed on 24 individuals from Dong Tao (DT), Cay Cum (CC), and Ri (RI) breeds. A total of 1743 CNVs were detected, clustering into 315 copy number variation regions (CNVRs). Most CNVRs were rare, with 31.7% present in only one animal among breeds. Across the genome, 122 unique CNVRs were distributed over 28 chromosomes, predominantly the first five. Losses were the most frequent type (45.9%), followed by gains (39.3%), and mixed events (14.8%). Within these CNVRs, 3633 genes were identified. In DT and RI, CNVR-embedded genes included several candidates, potentially related to adaptability, development, and phenotypic diversification. Notably, DT harbored genes such as , , , (adaptation, stress/immune response) and , , , , , , , and (developmental and skeletal traits), whereas in RI they included genes such as , , , and , which may contribute to muscle, bone, and physiological regulation. Functional enrichment analysis revealed numerous genes and Quantitative Trait Loci (QTLs) associated with metabolic, developmental, and immune-related pathways. This study provides the first comprehensive genome-wide CNV profile of Vietnamese indigenous chickens and offers a valuable genomic resource for investigating the genetic basis of breed-specific and adaptive phenotypes. - Source: PubMed
Publication date: 2026/04/01
Nguyen Thuy Thi-DieuTzvetkova AnaBui Mai Thi-DieuDo Vo-Anh-KhoaDinh Thuy Thi-NgocNguyen Phuong ThanhKuss Andreas WalterPenasa MauroCendron Filippo - Although anti-Zic4 antibodies are associated with paraneoplastic cerebellar degeneration, predominantly in small-cell lung carcinoma, their role in postinfectious autoimmunity remains poorly understood. - Source: PubMed
Suzuki-Yamamoto RisaNakajima AsukaFuruya TsuyoshiKoinuma TakahiroFuse AtsuhitoEguchi HirotoShimo Yasushi - Autoantibodies against intracellular neuronal antigens (IC-Abs) can be found in neurologically asymptomatic patients with small cell lung cancer (SCLC) and have been proposed as a predictive biomarker for the development of post-immune checkpoint inhibitors (ICIs) neurotoxicities. The aim of this study was to prospectively evaluate the association of baseline neural antibodies with immune-related adverse events (irAEs) - including neurological irAEs (n-irAEs) - and oncological outcomes in patients with SCLC following ICI therapy. - Source: PubMed
Publication date: 2025/11/20
Rossi SimoneAndrini ElisaRinaldi RitaSilvestri TaniaFormelli Maria GiovannaDi Odoardo AdrianaLenzi BarbaraGuarino MariaCampana DavideLamberti Giuseppe