c_Jun Antibody (Ab_239), pAb, Rabbit
- Known as:
- c_Jun Antibody (Ab_239), pAb, Rabbit
- Catalog number:
- A00235
- Product Quantity:
- 40ug
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- c_Jun Antibody (Ab_239) pAb Rabbit
Related products to: c_Jun Antibody (Ab_239), pAb, Rabbit
Related articles to: c_Jun Antibody (Ab_239), pAb, Rabbit
- Juniperus oxycedrus, from the Cupressaceae family, is widespread in the Mediterranean. However, the allergenic relevance of its pollen remains underexplored. Objective: This study aimed to characterize Jun o 1, an allergen of J oxycedrus that is homologous to major allergens in related species. - Source: PubMed
Publication date: 2026/05/07
Sivill SandraViñuela MarcosReal-Arévalo IreneMorán-Morales MiriamMoreno-Serna LuciaLópez-Sanz CeliaNuñez-Borque EmilioJiménez-Saiz RodrigoHernández-Walias Jose CMartínez-Cano SaraiIgea Juan MLemus Calderon Jose ANavarro-Pulido Ana MRondon CarmenFernandez-Caldas EnriquePineda FernandoSubiza Jose LIborra SalvadorCantillo Jose F - Macrophages coordinate inflammatory and immune responses to threats, yet how they interpret diverse danger signals to tailor inflammation remains unclear. Disturbances in extracellular and intracellular homeostasis alter cell volume, but the consequences for macrophage inflammatory responses are poorly understood. We demonstrate that macrophages use cell volume control as a danger-sensing mechanism to promote and augment inflammation. Using volume-regulated anion channel (VRAC)-deficient macrophages, which lack cell volume control under hypo-osmotic conditions, we show that cell volume disruptions drive transcriptomic reprogramming and induction of inflammation. Cell volume disruption induced type I interferon signaling through a DNA- and TBK1-dependent mechanism, but independent of cGAS and 2'3'-cGAMP transport. VRAC deficiency enhanced macrophage antiviral responses to influenza infection. Cell volume changes synergized with diverse pathogen-associated molecular pattern-mediated signaling to augment type I interferon responses and exacerbate the cytokine storm in mouse models of hyperinflammation. Our findings highlight cell volume as an important regulator in shaping inflammatory responses, expanding our understanding of how macrophages sense complex danger signals. - Source: PubMed
Publication date: 2026/05/07
Cook James RGleeson Tara AGago SaraAllan Stuart MCouper Kevin NLawrence Catherine BBrough DavidGreen Jack P - Repeated tumor contact leaves more behind than simple CAR-T exhaustion. This study by Gu et al. (https://doi.org/10.1084/jem.20252564) shows that chronic antigen exposure impairs a Rab5-dependent endocytic program, allowing trogocytosed antigen to accumulate, functional CAR to decline, and fratricide to increase. - Source: PubMed
Publication date: 2026/05/07
Park SangwooMaus Marcela V - Cushing'sdisease (CD), caused by an adrenocorticotropin-secreting pituitary adenoma, is a rare but severe endocrine disorder associated with high cardiometabolic morbidity and mortality. Diagnosis is challenging as many symptoms are nonspecific, and biochemical or imaging results may be inconclusive, contributing to substantial diagnostic delay. Although the core features of CD are consistent across the lifespan, certain clinical manifestations of chronic hypercortisolism vary from childhood through older age, reflecting differences in growth, puberty, metabolism, and comorbidity burden. In children, impaired growth coupled with weight gain is most prominent, whereas adolescents often present with pubertal disturbances and psychological or academic difficulties. Adults typically exhibit the classic Cushingoid features such as round face, plethora, and central obesity, along with metabolic and reproductive complications. Older individuals typically present with frailty, sarcopenia, fractures, and cognitive decline. Age also influences the interpretation of endocrine tests, the accuracy of pituitary magnetic resonance imaging, the role of inferior petrosal sinus sampling, perioperative risks, and the long-term impact of remission or persistent disease. Given this context, this narrative review used five representative clinical vignettes (pediatric, adolescent, adult female, adult male, and elderly) to illustrate how the presentation, diagnostic evaluation, and management of CD vary across the lifespan. Each case was paired with a structured synthesis of current evidence, highlighting both shared principles and age-specific nuances essential for timely diagnosis, appropriate treatment selection, and effective long-term multidisciplinary care. Understanding age-related differences is crucial to improving outcomes and reducing the substantial morbidity and mortality associated with CD throughout the lifespan. - Source: PubMed
Publication date: 2026/06/01
Nowak ElisabethSchweizer Júnia Ribeiro de Oliveira LongoBoguszewski Margaret Cristina da SilvaReincke MartinBoguszewski Cesar Luiz - - Source: PubMed
Publication date: 2026/06/01
Caldato Milena Coelho Fernandes