IRS_1 Antibody (Ab_636), pAb, Rabbit
- Known as:
- IRS_1 Antibody (Ab_636), pAb, Rabbit
- Catalog number:
- A00575
- Product Quantity:
- 40ug
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- IRS_1 Antibody (Ab_636) pAb Rabbit
Related genes to: IRS_1 Antibody (Ab_636), pAb, Rabbit
- Gene:
- IL20RB NIH gene
- Name:
- interleukin 20 receptor subunit beta
- Previous symbol:
- FNDC6
- Synonyms:
- DIRS1, IL-20R2, MGC34923
- Chromosome:
- 3q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-23
- Date modifiied:
- 2015-12-11
- Gene:
- IRS1 NIH gene
- Name:
- insulin receptor substrate 1
- Previous symbol:
- -
- Synonyms:
- HIRS-1
- Chromosome:
- 2q36.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-24
- Date modifiied:
- 2016-10-05
- Gene:
- KRT71 NIH gene
- Name:
- keratin 71
- Previous symbol:
- -
- Synonyms:
- KRT6IRS, KRT6IRS1, K6IRS1
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-17
- Date modifiied:
- 2016-03-09
Related products to: IRS_1 Antibody (Ab_636), pAb, Rabbit
Related articles to: IRS_1 Antibody (Ab_636), pAb, Rabbit
- Type 2 diabetes (T2D) is a heterogeneous disorder with substantial variation in age at onset (AAO). This study aimed to characterize the distinct genetic architectures and biological mechanisms underlying extreme AAO-defined T2D subtypes. - Source: PubMed
Publication date: 2026/09/08
Niu BenXia Ming-HuiWu Jia-XinDeng Fei-YanWu Hai-YingLei Shu-Feng - Insulin resistance (IR) is the key driver of type 2 diabetes mellitus, metabolic dysfunction-associated steatotic liver disease, and cardiometabolic disorders. Mesenchymal stem cell-derived exosomes (MSC-Exos) as a potent cell-free alternative can deliver miRNAs, proteins, and mitochondrial regulators to reactivate the IRS1/PI3K/Akt/GLUT4 axis. Beyond restoring insulin signalling, these vesicles can protect β-cells, alleviate endoplasmic reticulum stress, rescue mitochondrial mitophagy and respiration. The genetic engineering strategies including improving the expression of miR-21, miR-3075, or Sirtuin-3, and silencing miR-29b-3p amplify the therapeutic efficacy. However, scalable good manufacturing practice production, long-term safety of modified products, and advanced therapy medicinal product regulation are still needed to overcome. This review will introduce the potential of gene-modified MSC-Exos and miRNAs targeting insulin signalling and mitochondrial rescue, which have shown a shift from symptomatic relief to precision disease-modifying therapy for IR. - Source: PubMed
Jia QinghuaLi BingXing YuanZhang YuanyuanGao BaodongLi XiangyingHa Xiaoqin - Subcellular annexin A2 (ANXA2) is known to regulate membrane dynamics and GLUT4 trafficking in adipocytes; however, the role of serum ANXA2 in glucose metabolism remains unclear. We aimed to investigate the association between fasting serum ANXA2 and insulin sensitivity in humans and to examine the role of extracellular ANXA2 in glucose uptake in cultured skeletal myocytes. - Source: PubMed
Publication date: 2026/09/04
Ito YuichiOkura TsuyoshiAnno MariKitao SonokoEndo SatomiIchihara YoshinoriSawano TatsuyaMiake JunichiroUeta EtsukoKato MasahikoTaniguchi Shin-IchiYamamoto KazuhiroImamura Takeshi - There is few research on which genes play an important role in tumors without lymph metastasis. This study aimed to identify candidate molecular alterations preferentially associated with N0-stage LUSC. - Source: PubMed
Publication date: 2026/08/31
Alipour MarzyehMoghanibashi MehdiNaeimi SirousMohamadynejad Parisa - Regulation of skeletal muscle glucose uptake is an effective strategy for reducing postprandial hyperglycemia and improving whole-body glucose homeostasis in the management of type 2 diabetes. The present study investigated that cardamom enhances glucose uptake in skeletal muscle in vitro and improves glucose tolerance in vivo. Bioactivity-guided fractionation of cardamom identified an ethyl acetate fraction (Fr. A) and its subfraction (Fr. A-i) as potent stimulators of glucose uptake in L6 myotubes. Both fractions significantly promoted glucose uptake by enhancing glucose transporter type 4 (GLUT4) translocation to the plasma membrane. Mechanistic investigations revealed activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, accompanied by increased phosphorylation of Akt substrate of 160 kDa (AS160), a key regulator of GLUT4 vesicle trafficking, while no significant changes were observed in insulin receptor substrate-1 (IRS-1) or AMP-activated protein kinase (AMPK) phosphorylation. Fr. A induced a more pronounced effect on AS160 phosphorylation and was therefore selected for further evaluation. The antihyperglycemic potential of Fr. A was assessed in ICR mice using an oral glucose tolerance test. Oral administration of Fr. A (1 and 10 mg/kg body weight) significantly improved glucose tolerance and alleviated postprandial hyperglycemia. Cardamom in skeletal muscle and highlights its potential as a natural therapeutic candidate for the management of postprandial hyperglycemia. - Source: PubMed
Fang LiyuanHironao Ken-YuAshida HitoshiYamashita Yoko