GHP_31 Human IGF_I
- Known as:
- GHP_31 Human IGF_I
- Catalog number:
- GHP-31
- Product Quantity:
- 1 mg
- Category:
- -
- Supplier:
- PLR
- Gene target:
- GHP_31 Human IGF_I
Related genes to: GHP_31 Human IGF_I
- Gene:
- IGF1 NIH gene
- Name:
- insulin like growth factor 1
- Previous symbol:
- -
- Synonyms:
- IGF1A, IGFI, IGF-I, IGF
- Chromosome:
- 12q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2018-06-04
- Gene:
- IGF1R NIH gene
- Name:
- insulin like growth factor 1 receptor
- Previous symbol:
- -
- Synonyms:
- JTK13, CD221, IGFIR, MGC18216, IGFR
- Chromosome:
- 15q26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-07
- Date modifiied:
- 2019-04-23
Related products to: GHP_31 Human IGF_I
Related articles to: GHP_31 Human IGF_I
- Hypoglycemia may result from multiple clinical conditions which are categorized based on clinical status. The first principal step in clinical diagnostic evaluation is measurement of plasma insulin, c-peptide, pro-insulin, and beta-hydroxybutyrate levels. One of the rare causes of hypoglycemia is a group of disorders known as non-islet cell tumor hypoglycemia (NICT), which results from the paraneoplastic secretion of insulin-like growth factor 2 (IGF-2). In rare cases, Solitary fibrous tumors SFTs are associated with recurrent hypoglycemia and represent the most frequent subtype of NICT. - Source: PubMed
Publication date: 2026/07/12
Sheikhi SetareKhajeZadeh SoheilaFallahi Mohammad JavadJeddi Marjan - In sheep, chronic undernutrition during twin gestation abolishes birth weight sexual dimorphism, being partially restored by antioxidants supplementation. The aim was to evaluate differences in the maternal-fetal endocrine environment and its influence on the differential growth of female and male fetuses in ovine twin pregnancies with discordant-sex conceptuses maintained under natural undernutrition, and to assess the effect of antioxidant supplementation and concentrated feed. Three groups of ewes (n = 10 each) were compared: the control group (C) was maintained exclusively on natural pasture (∼70% of energy and 30% of protein requirements). From day 62 to term, treated groups received antioxidants (AOx) or concentrate (NS). At 117 and 142 days of gestation (dGA), maternal plasma samples were collected to measure estradiol, progesterone, and cortisol, while umbilical cord plasma samples were obtained to measure insulin, IGF-1, IGF-2, and fetal cortisol. Lambs were delivered by cesarean section at 142 dGA, body weight was recorded, and a fetal skeletal muscle sample was collected for mTOR analysis by Western blot. Treatments did not affect maternal hormones. At 117 dGA, AOx and NS supplementation increased fetal plasma concentrations of IGF-1 and IGF-2; conversely, male fetuses of the Control group had lower IGF-1 and higher cortisol concentrations than their female co-twins. At 142 dGA, male fetuses showed higher concentrations of insulin and IGF-1, which were consistent with the expression of activated mTOR in muscle. It is concluded that maternal undernutrition imposes a greater burden on male fetuses, suppressing the growth axis; antioxidants partly reverse this, whereas maternal concentrate supplementation largely restores it. - Source: PubMed
Publication date: 2026/07/08
Sales FranciscoPeralta Óscar ASandoval CamilaCartagena CristóbalRuiz GressiaReyes Mónica De LosCarrasco AlbertGonzález-Bulnes AntonioParraguez Víctor H - In fish, early puberty can lead to divergent growth trajectories and increased size dispersion within populations. In European sea bass, this pattern is evident by the end of the second year, with females of greater body weight generally tending to reach puberty earlier, although this association is not always consistent. This study investigates the factors influencing the relationship between growth and reproductive maturation in this teleost fish. Four female groups were defined based on body weight (small, S; large, L) and gonadal development (immature, I; advanced, A): SI, SA, LI, and LA. Results showed that larger fish size did not always correspond with a more advanced gonadal stage (late vitellogenesis). Furthermore, females with a higher condition factor during the spring-summer period preceeding putative gonadal development (PGD; autumn-winter months), exhibited elevated plasma levels of follicle stimulating hormone and insulin-like growth factor 1 (Igf-1). These females showed a higher gonadosomatic index (GSI), as well as elevated plasma levels of 17β-estradiol and vitellogenin during the PGD period. This suggests that body condition before PGD may be critical for fish to subsequently meet reproductive demands, as females likely with insufficient energy reserves were unable to sustain the costs associated with maturation later on (i.e., SI, LI vs. SA, LA). Levels of igf expression were linked to ovarian development and were positively correlated with intraovarian lipid gene expression. Of note, SA and LA females displayed increased ovarian expression of igf-2 and lipoprotein lipase (lpl) in comparison to that of SI and LI females. The ovarian igf-2 correlated with GSI and ovarian expression of lpl, suggesting that igf-2 might potentially promote lipid uptake. These findings indicate that body size alone does not predict ovarian development in European sea bass, whereas lipid accumulation appears critical for triggering gonadal development, emphasizing the role of energy status in the relationship between growth and reproduction in this species. - Source: PubMed
Publication date: 2026/07/04
Sempere LauraIbáñez SoledadMarín ConradoMolés GregorioCalduch-Giner JosepPérez-Sánchez JaumeFelip Alicia - In mammals, insulin-like growth factor (IGF)-1 and IGF-2 regulate postnatal growth and embryonic development, respectively. In fish, as in mammals, IGF-1 promotes somatic growth, whereas evidence suggests the possible involvement of IGF-2 in the regulation of somatic growth. However, the measurement of circulating IGF-2 in fish has been hampered, possibly because of interference from IGF-binding proteins (IGFBPs). Extraction of IGFs from IGFBPs is essential before measuring them using immunoassays. We optimized acid-ethanol (AE) extraction method for salmonid IGF-2 and developed a time-resolved fluoroimmunoassay (TR-FIA) using recombinant IGF-2 as the assay component. In TR-FIA, the standard AE-extraction of IGF-1 was not validated for quantifying serum IGF-2 because of the presence of ethanol. Three treatments-vacuum drying, dialysis, and ultrafiltration-were compared after AE extraction, and ultrafiltration by centrifugation was found to be effective. With this extraction method, circulating IGF-2 levels were measured by TR-FIA in fed, fasted, and refed rainbow trout. Serum IGF-2 levels were similar or slightly lower in fed fish than in fasted fish, and refeeding had no positive effect. Serum IGF-2 levels were not correlated with individual growth rates. GH treatment tended to increase circulating IGF-2 levels albeit not statistically significant. Smolting masu salmon had similar but slightly lower serum IGF-2 levels than non-smolting fish, while exhibiting high serum IGF-1 levels. These results suggest that circulating IGF-2 levels were relatively stable. This newly developed assay should facilitate further exploration of the physiological responses and roles of circulating IGF-2 in salmonids. - Source: PubMed
Publication date: 2026/07/04
Izutsu AyakaSuzuki ShuntaroKitade HarukaShimizu Munetaka - Pesticide pollution in aquatic ecosystems has been increasing, especially organophosphates such as sumithion, which pose serious risks to non-target aquatic species including Nile tilapia (Oreochromis niloticus). In our study, we systematically assessed the therapeutic effects of probiotics and Spirulina platensis on sumithion-induced oxidative stress, immunosuppression, hematological alterations, and growth inhibition in O. niloticus. A total of 240 fingerlings (12.8 ± 0.09 g) were chosen randomly to receive four treatments for experimentation: control, sumithion (0.30 mg/L), sumithion and probiotics (0.30 mg/L and 1.0 ml/L), and sumithion and Spirulina (0.30 mg/L and 50 g/kg). Each treatment had three repetitions for a duration of six weeks. The exposure of fish to sumithion caused impaired growth performance, significant (p < 0.05) increase in metabolic and oxidative stress markers, as well as a decrease in hemoglobin (Hb) concentration, induced hyperglycemia, and downregulation of immune gene expression. Conversely, treatments with probiotics and Spirulina effectively ameliorated these toxic effects. Probiotics were effective in restoring immune gene expression (interferon-gamma, IFN-γ, interleukin-1 beta, IL-1β; and tumor necrosis factor-alpha, TNF-α), reducing glucose (Glu) levels, and improving growth performance, as evidenced by the highest weight gain, specific growth rate, and increased intestine-somatic index (ISI) and lowest feed conversion ratio. Furthermore, the probiotic-supplemented group showed an upregulation in hepatic igf-1, igf-2 (insulin-like growth factors) and pituitary gh (growth hormone) expression levels. In contrast, Spirulina had a greater impact on promoting antioxidant activity and boosting hematological parameters, particularly by improving Hb, SOD (superoxide dismutase), and CAT (catalase) levels, while also contributing to a significant increase in hepatosomatic index (HSI). These results emphasize the effectiveness of probiotics and Spirulina as eco-friendly complements to alleviate sumithion-prevailed toxicity, enhancing growth, immune response, and antioxidant capacity in O. niloticus, with probiotics being an effective approach in easing physiological impairments. - Source: PubMed
Publication date: 2026/07/02
Ahmed ShaharierEtti Esrat ZahanAmin Md RuhulKhanom HaphsaNoor Shifat AraShahjahan MdZahangir Md Mahiuddin