Compact Multi Gel Cast
- Known as:
- Compact Multi Gel Cast
- Catalog number:
- 2322600
- Category:
- -
- Supplier:
- Ato
- Gene target:
- Compact Multi Gel Cast
Related genes to: Compact Multi Gel Cast
- Gene:
- CAST NIH gene
- Name:
- calpastatin
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q15
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-03
- Date modifiied:
- 2015-08-24
Related products to: Compact Multi Gel Cast
Related articles to: Compact Multi Gel Cast
- Transphyseal separation of the distal humerus (TSDH) is an uncommon injury, typically seen in children under 3 years of age, with very few cases reported beyond this age group. Diagnosing this injury is challenging due to its cartilaginous nature. TSDH in infants is commonly treated with manual reduction and long-arm cast application; however, a few case series have suggested that surgical treatment may be a better option in older children. - Source: PubMed
Publication date: 2026/08/27
Pokhrel SushilKarki ShivajiSah SushilTiwari Ganga - The valorization of agro-industrial waste for producing sustainable and functional packaging is a key strategy within the circular economy and green chemistry. This study developed active antioxidant edible films by incorporating a phenolic-rich extract from yellow passion fruit seeds into two composite polysaccharide matrices: β-glucan/carboxymethyl cellulose (BG/CMC) and β-glucan/citrus pectin (BG/PEC). The phenolic extract, obtained through a sequential ultrasound-assisted extraction from defatted yellow passion fruit seeds, was incorporated into the film-forming solutions at different concentrations (0, 57, 114, and 190 μg GAE/mL), which were subsequently cast and dried. The films were thoroughly characterized. Both film series exhibited excellent UV light barrier properties and homogeneous morphology. The BG/CMC films were fully water-soluble and showed the highest antioxidant activity (up to 19.42 μmol TE/g by TEAC assay) at the highest extract concentration. In contrast, BG/PEC films demonstrated superior and enhanced mechanical properties when loaded with the highest extract amount, achieving a balanced combination of tensile strength (3.64 MPa) and elongation at break (20.84%). Structural analyses (FTIR, XRD, and TGA) confirmed the successful incorporation of the extract and revealed an amorphous structure with good thermal stability. The BG/PEC films showed visible enhancement on thermal stability with the incorporation of the phenolic extract, in any concentration, with a final mass loss near 30%. All films showed good synergy within the matrices ingredients, corroborated by the FTIR spectra where the main bands were still present. The results demonstrate that the choice of the polysaccharide matrix (CMC vs pectin) dictates the final functional profile of the active film. This work successfully transforms passion fruit processing waste into tailorable, antioxidant edible films, providing sustainable alternatives for active food packaging applications. - Source: PubMed
Publication date: 2026/08/11
Xavier Guilherme FelipeLopes Faria Gessica MariaSilva Eric KevenLopes Melina Savioli - Oligonucleotide drugs, such as small interfering RNAs (siRNAs) and small activating RNAs (saRNAs), are rapidly advancing in the clinic. However, a complete picture of their intracellular uptake, trafficking, and fate remains elusive. Additionally, the double-stranded nature of the compounds makes it challenging to track both the guide and passenger strands individually. To address this, we present a proof-of-concept study of nanoscale secondary ion mass spectrometry (NanoSIMS) in combination with a dual-labeling strategy using 5-bromo- and 5-iodo-modified uracil to detect, discriminate, and quantify both strands without relying on bulky fluorescent tags. By evaluating GalNAc-conjugated siRNAs and saRNAs in HepG2 cells, we demonstrate that NanoSIMS can effectively codetect guide and passenger strands within the endolysosomal compartments. For the siRNA design, imaging revealed, as expected, a robust correlation between the strands. Conversely, we highlight the use of NanoSIMS as a potential aid in the optimization of guide strand stability by exploring different chemical designs for the saRNA. This work highlights the potential of NanoSIMS to quantitatively monitor individual double-stranded RNA strands and their subcellular localization in vitro, offering a valuable tool to generate critical trafficking and quantitative data for oligonucleotide therapeutics. - Source: PubMed
Publication date: 2026/08/14
Vicentini QuentinKurczy MichaelEstupiñán H YesidHekman DennisBecquart CécileHaag LarsAndersson ShaliniEl-Andaloussi SamirDahlén Anders - Atherosclerosis represents the primary pathological basis of cardiovascular diseases. Vascular stent implantation as a key intervention for treating atherosclerosis, currently faces challenges such as the lack of personalized customization, difficulty in precisely matching diseased vessels, and prolonged risks of thrombosis and restenosis. Inspired by the shape-shifting liquid-metal robot T-1000 from the film , this research pioneers the use of liquid metal (LM) in vascular interventional therapy. LM was cast into a mold, then drilled and ground to the Hep/PLL/PDA/LM stent. Its heparin coating confers effective anti-thrombogenic activity and mitigates restenosis. More importantly, after the process of vascular remodeling, the stent can be degraded non-invasively through the application of an alternating magnetic field. Furthermore, the stent material exhibits notable antioxidant and anti-inflammatory properties. The findings above suggest that the magnetothermal characteristics of LM make it possible to precisely match diseased vessels and achieve controllably degradable vascular interventional therapy. This capability can fundamentally address the safety risks associated with the prolonged presence of traditional vascular stents, potentially eliminating the necessity for follow-up surgical interventions. - Source: PubMed
Publication date: 2026/08/13
Xiong JianxiangHuang LiHuang JingzhengZhou ZhibinHu ShenZhao WenpengXu GuizhenLai XingchunYang GuoyuZhou WeiminWang Xiaolei - Intra-radicular posts are routinely used in restoring endodontically treated teeth to enhance retention and evenly distribute functional loads. The material of the post plays a critical role in stress transmission within the tooth and supporting structures, directly influencing long-term prognosis. Therefore, it is of interest to evaluate stress distribution patterns among different post materials, specifically fiber-reinforced composite, cast metal and stainless steel posts. Fiber posts, due to their modulus of elasticity similar to dentin, showed more favorable stress dispersion and reduced risk of root fracture in biomechanical analyses. Metallic posts exhibited stress concentration at apical and cervical regions, increasing fracture susceptibility. Thus, we show the importance of considering biomechanical compatibility, not just strength and retention, when selecting post materials to improve restoration longevity and overall clinical success. - Source: PubMed
Publication date: 2026/05/31
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