GLI1
- Known as:
- GLI1
- Catalog number:
- AP05303SU-N
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- GLI1
Related genes to: GLI1
- Gene:
- GLI1 NIH gene
- Name:
- GLI family zinc finger 1
- Previous symbol:
- GLI
- Synonyms:
- -
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-01-15
Related products to: GLI1
Related articles to: GLI1
- Renal fibrosis lacks experimentally tractable human-relevant models that integrate defined stromal programming with spatially controlled profibrotic cues. Here, we developed a dual E-/VE-cadherin-Fc (EVE) interface to condition human mesenchymal stem cells (MSCs) under CTGF/TGF-β stimulation. Cells showed increased expression of Gli-1, NG2, PDGFRβ, and FAP and activated transcription of extracellular matrix remodeling. These changes were consistent with the acquisition of a Gli-1 perivascular-like profibrotic stromal phenotype, and were accompanied by reorganization of cadherin-catenin complexes, actin cytoskeletal rearrangement, and increased YAP nuclear localization. Cell-sized PLGA/chitosan-heparin microparticles were subsequently functionalized with E-/VE-cadherin-Fc and loaded with CTGF/TGF-β. Co-assembly of these microparticles with the conditioned stromal cells (gMSCs) and renal epithelial cells (HK-2) generated 3D renal fibrotic microtissues that combined cadherin-mediated adhesive presentation with localized cytokine delivery. The resulting microtissues exhibited a broader distribution of α-SMA, Collagen I, and Fibronectin, together with reciprocal epithelial-stromal signaling and spatially organized fibrotic activation. As a proof of concept for pharmacological evaluation, the microtissues responded to pirfenidone (PFD) in a dose-dependent manner, with 100 µM PFD reducing α-SMA expression by ∼73% while preserving microtissue viability. Together, these findings establish a material-enabled, cadherin-guided strategy for constructing disease-relevant stromal organization and spatially controlled profibrotic signaling in human renal fibrosis models. - Source: PubMed
Publication date: 2026/09/20
Cheng ZhongQu ZhanyuanSun JiaxinDuan ZhihuaAn YongZhang YanYang Jun - Cerebral ischemia-reperfusion injury (CIRI) triggers endoplasmic reticulum stress (ERS), a key pathological driver of neuronal apoptosis and neurological impairment. While the neuroprotective effects of astragaloside IV (AS-IV) are well-documented, the precise regulatory bridge between the Sonic Hedgehog (SHH) pathway and ERS remains to be elucidated. - Source: PubMed
Publication date: 2026/09/18
Wei PingboHan YangyunWang JunLuo LeMeng JiangFan BoLiu Jiaxin - Arsenic disulfide (AsS) inhibits proliferation and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells, its clinical application is constrained by toxicity. Metformin has also been reported to exert antitumor effects across various malignancies. This study investigated whether metformin potentiates the anti-lymphoma efficacy of AsS in DLBCL cells and evaluated associated alterations in apoptosis-related markers and Hedgehog signaling molecules. - Source: PubMed
Publication date: 2026/09/01
Zhang JiahaoLi HuaweiZhao MingxinChen ChenDu ShenghongWang Ling - Sonic hedgehog (SHH) expression by nucleus pulposus (NP) cells is important for intervertebral disc development and maintenance. The lumbosacral disc, the most immobile region of the spine, lies adjacent to the sacrum and is most vulnerable to degeneration. We hypothesized that a lack of mobility represses SHH expression by NP cells, leading to degenerative changes in the intervertebral disc. To test this hypothesis, we employed a -LacZ reporter mouse and a tail-loop surgical model of constant compression and immobility. Using a comprehensive level-by-level analysis, we first determined the coccygeal level most affected by geometric and histopathological changes. We next determined the effects of constant compression and immobility on the subset of SHH-expressing cells compared with sham controls. Multiplex qPCR analysis validated a decline in and its target expression by NP cells in the tail-looped discs that was associated with an increase in expression compared to sham controls. In summary, the findings support a model in which restricted mobility and sustained compression in lumbosacral discs accelerate pathology by prematurely silencing developmental signaling programs, such as SHH, required for NP homeostasis. - Source: PubMed
Publication date: 2026/08/22
Virk SohrabShah VeerajPiprode VikrantKemp Claire MarieAlluri HarshithVincent Kathleen FKrishnan RaviHong JustinAlbert Todd JDahia Chitra L - Androgenetic alopecia (AGA), the most common form of hair loss, is driven by dihydrotestosterone-mediated follicular miniaturization, oxidative stress, and perifollicular inflammation, requiring multi-target intervention. Coffee pulp is an abundant coffee-processing by-product and a potential source of value-added bioactives relevant to AGA. This study investigated whether fermentation with , , or their mixed culture could remodel coffee pulp composition and enhance biological activities relevant to AGA. Untargeted metabolomics revealed treatment-dependent metabolic remodeling. LP-CP showed the largest number of significantly altered metabolite features (1020; 666 increased and 354 decreased), whereas MIX-CP exhibited a predominantly upward pattern, with 238 of 283 significantly altered features (84.10%) showing increased abundance relative to the unfermented control. Targeted polyphenol analysis showed MIX-CP contained the highest levels of rosmarinic acid and quercetin. In human hair follicle dermal papilla cells, MIX-CP stimulated proliferation, increased fibroblast proliferation in a conditioned-medium model, partially rescued cell viability under potassium-channel inhibition, and attenuated intracellular reactive oxygen species and lipid peroxidation more than monoculture-fermented extracts. At the transcriptional level, MIX-CP downregulated androgen metabolism genes and alongside pro-regression mediator TGFB1 while upregulating Wnt/β-catenin (), Sonic Hedgehog (, , ), and angiogenic () genes, showing transcript-level modulation comparable to standard hair-loss drugs for most targets. These findings position MIX-CP as a promising multi-target cosmeceutical for AGA management, warranting further in vivo validation. - Source: PubMed
Publication date: 2026/09/02
Muangsanguan AnurakRuksiriwanich WarintornPanti NiphawanSawangrat KasirawatPummara PattarapaRachtanapun PornchaiSringarm KorawanSommano Sarana RoseKrobthong SucheewinArjin ChaiwatSatsook ApinyaCastagnini Juan Manuel