Reticulon 1 _ RTN1 (Isoform RTN1_C)
- Known as:
- Reticulon 1 _ RTN1 (Isoform RTN1_C)
- Catalog number:
- BM6041P
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Reticulon 1 _ RTN1 (Isoform RTN1_C)
Related genes to: Reticulon 1 _ RTN1 (Isoform RTN1_C)
- Gene:
- RTN1 NIH gene
- Name:
- reticulon 1
- Previous symbol:
- NSP
- Synonyms:
- -
- Chromosome:
- 14q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-08-24
- Date modifiied:
- 2016-10-05
Related products to: Reticulon 1 _ RTN1 (Isoform RTN1_C)
(Biotin Conjugates) Phospho-Slingshot 1 isoform 1 antibodies Immunogen: peptide Host: Rabbit(FITC-conjugates) Phospho-Slingshot 1 isoform 1 antibodies Immunogen: peptide Host: Rabbit14-3-3 Isoform Panel, Rabbit anti-;14-3-3 protein c-isoform antibody Host rabbit14-3-3 protein c-isoform antibody Ab host: Rabbit14_3_3 Isoform Panel, Rabbit anti_;20 kDa myosin light chain,Homo sapiens,Human,LC20,MLC2,MLC-2C,MRLC1,MYL9,Myosin regulatory light chain 2, smooth muscle isoform,Myosin regulatory light chain 9,Myosin regulatory light chain MRLC1,Myos20 kDa myosin light chain,LC20,MYL9,Myosin regulatory light chain 2, smooth muscle isoform,Myosin regulatory light chain 9,Myosin regulatory light polypeptide 9,MYRL2,Pig,Sus scrofa3_hydroxyisobutyryl_Coenzyme A hydrolase isoform 24-alpha-hydroxy-tetrahydropterin dehydratase 2,Chicken,DCoH-alpha,DcoH-like protein DCoHm,DCOHM,Gallus gallus,Hepatocyte nuclear factor 1a dimerization cofactor isoform,PCBD2,PHS 2,Pterin-4-alpha-carb40S ribosomal protein S4, X isoform,CCG2,Homo sapiens,Human,RPS4,RPS4X,SCAR,SCR10,Single copy abundant mRNA protein40S ribosomal protein S4, X isoform,Mouse,Mus musculus,Rps4,Rps4x40S ribosomal protein S4, X isoform,Rat,Rattus norvegicus,Rps4,Rps4x40S ribosomal protein S4, Y isoform 1,Homo sapiens,Human,PRO2646,RPS4Y,RPS4Y140S ribosomal protein S4, Y isoform 2,Homo sapiens,Human,RPS4Y2,RPS4Y2P Related articles to: Reticulon 1 _ RTN1 (Isoform RTN1_C)
- Metastasis is the primary cause of mortality in patients with breast cancer. This study aimed to develop a prognostic signature based on metastasis- and cancer-associated differentially expressed genes (M-CA-DEGs) and to identify potential novel therapeutic genes. - Source: PubMed
Publication date: 2026/05/11
Yao YuanZheng YunshengXie JiancongLiu HonghaoChen ChenCao JieYin Ting-Ting - Poorly differentiated endometrial carcinoma in Black African women is under-characterized at the transcriptomic level, although it is known for aggressive subtypes. We conducted the first RNA-seq analysis of formalin-fixed, paraffin-embedded (FFPE) tumors from Black South African women to explore population-specific gene expression, alternative splicing, and novel isoforms. - Source: PubMed
Publication date: 2026/03/24
Molefi ThuloAlaouna MohammedChipiti TalentSebitloane HannahDlamini Zodwa - Encephalitis resulting from acute reactivation of chronic infection in the central nervous system poses a significant mortality risk in immunodeficient individuals. However, the specific molecular mechanisms underlying this process remain elusive. We constructed the GRA35 gene knockout ME49 strain and compared the differences with wild type ME49 strain. We used the GST-pull down experiment to explore the mechanism of GRA35 promoting neuronal cell apoptosis. We used immunofluorescence, flow cytometry and CCK8 experiments to verify the pathway of GRA35 promoting neuronal cell apoptosis. Our study reveals that wild type ME49 strain promotes neuronal apoptosis in brain following chronic infection activation. Conversely, infection with the ME49 strain leads to a reduced apoptotic response in brain neurons. Furthermore, we demonstrate that GRA35 interacts with RTN1-c, thereby promoting mitochondrial pathway-mediated apoptosis in neurons. Additionally, GRA35 can trigger host cell ER stress-associated apoptosis through the PERK signaling pathway. GRA35 serves as a crucial virulence factor in the pathogenesis of Toxoplasmic encephalitis (TE), which offers potential new therapeutic target and theoretical insights for TE. - Source: PubMed
Publication date: 2026/04/10
Wang JieChen YingZhou NanLi FangminDai NiuniuChen ZhiangLiu ShutongAn RanChen LijianDu Jian - The introduction of domestic cattle to the Philippines is often attributed to Spanish and Chinese sources, yet the origins and adaptive history of Philippine Visayan native cattle remain unclear. This study examined the ancestry, structure, and putative selection signals of the Visayan native cattle from Panay and Siquijor islands (VNC) in a global context. Using genome-wide SNP data, population structure was assessed by PCA, IBS/Nei/ trees, and ADMIXTURE; historical relationships were explored with migration, f-statistics, and an admixture graph; and positive selection was scanned using commonly used methods such as ROH, Tajima's , iHS/XP-EHH, and with cross-validation across methods and functional enrichment of the overlapping regions. VNC exhibited low-to-moderate genetic diversity (Ho and He ≈ 0.21; and FIS = 0.01 to 0.02) with Siquijor enriched for long ROH segments indicating recent inbreeding. Across multiple complementary analyses, VNC showed predominantly indicine ancestry and occupied an intermediate bridge-like position between indicine from mainland Southeast Asia and from Southeastern China, with additional components that were most similar to Iberian taurine cattle and South Asian indicine. Moreover, the current study identified putative selection signatures that would possibly provide insights to better understand the local adaptation of VNC under insular tropical conditions of the Philippines: (1) small stature ( cluster, , , , ), (2) heat tolerance and immune robustness (, , , , , ); (3) early reproductive and maturity reproductive performance (, , , ). Overall, the VNC in Panay and Siquijor showed a predominantly indicine ancestry with putatively island-adapted physiology, emphasizing the need for conservation and island-specific breeding that preserves local adaptation while managing inbreeding. - Source: PubMed
Publication date: 2026/02/09
Dominguez Jorge Michael DYebron Medino Gedeun NBanayo Joy BChen NingboSalces Agapita JKim Kwan Suk - Psychosomatic disorders are conditions in which physical (somatic) symptoms are triggered or aggravated by psychological distress. These disorders result from complex interactions among the endocrine, central nervous, and immune systems. Emerging evidence indicates that gut microbiota (GM) dysbiosis, epigenetic alterations, and immune system dysregulation play pivotal roles in the pathogenesis of psychosomatic disorders and may serve as potential biomarkers for disease states and therapeutic outcomes. This review first outlines how epigenetic dysregulation contributes to psychosomatic disorders through altered expression of genes such as GRM2, TRPA1, SLC6A4, NR3C1, leptin, BDNF, NAT15, HDAC4, PRKCA, RTN1, PRKG1, and HDAC7. We then examine current evidence linking psychosomatic disorders with changes in GM composition and GM-derived epigenetic metabolites, which influence immune function and neurobiological pathways. The core focus of this review is on therapeutic interventions-including probiotics, prebiotics, postbiotics, fecal microbiota transplantation, and targeted dietary approaches-that modulate the gut-brain axis through epigenetic mechanisms for the management of psychosomatic disorders. Finally, we highlight the current challenges and future directions in elucidating the interplay between epigenetics, the GM, and psychosomatic disease mechanisms. In this context, human iPSC-derived multicellular organoids may serve as powerful platforms to unravel mechanistic pathways underlying inter-organ interactions. - Source: PubMed
Publication date: 2025/12/10
Mostafavi Abdolmaleky HamidPirani AhmadPettinato Giuseppe