GATA2 (+GATA3)
- Known as:
- GATA2 (+GATA3)
- Catalog number:
- AP20230PU-N
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- GATA2 (+GATA3)
Related genes to: GATA2 (+GATA3)
- Gene:
- GATA2 NIH gene
- Name:
- GATA binding protein 2
- Previous symbol:
- -
- Synonyms:
- NFE1B
- Chromosome:
- 3q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-03
- Date modifiied:
- 2019-04-23
- Gene:
- GATA3 NIH gene
- Name:
- GATA binding protein 3
- Previous symbol:
- -
- Synonyms:
- HDR
- Chromosome:
- 10p14
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-03
- Date modifiied:
- 2016-10-05
Related products to: GATA2 (+GATA3)
Related articles to: GATA2 (+GATA3)
- Not available. - Source: PubMed
Publication date: 2026/06/11
Kotmayer LiliWlodarski Marcin W - Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) refers to liver cancer caused by chronic HBV infection and is the leading cause of liver cancer globally. Although aurora kinase A (AURKA) has been reported to be highly expressed in HBV-associated HCC, its specific mechanisms of action remain unclear. Through bioinformatics analysis (Gene Expression Omnibus (GEO)) and experimental validation (Western blot), the expression levels of AURKA, hepatitis B virus X protein (HBX), and GATA binding protein 2 (GATA2) were assessed. A HepG2.2.15 cell model was established. Functional assays (colony formation, flow cytometry, mouse xenograft tumor model) and mechanistic studies (dual-luciferase reporter assay, JASPAR database analysis, and chromatin immunoprecipitation (ChIP)) were conducted to investigate the mechanism of AURKA in HBV-associated HCC. Bioinformatics analysis identified AURKA as a core gene in HBV- associated HCC. AURKA was highly expressed in HBV-associated HCC. Knockdown of AURKA inhibited the proliferation of HepG2.2.15 cells, induced apoptosis, and reduced the protein level of the autophagy substrate P62 as well as the ratio of the autophagy marker LC3BII/LC3BI. By forming a complex with GATA2, HBX enhanced the transcriptional activity of the AURKA promoter, thereby promoting the malignant phenotypes of HepG2.2.15 cells. Additionally, in vivo experiments demonstrated that knockdown of GATA2 inhibited tumor growth. In conclusion, GATA2-regulated AURKA promotes the development of HBV-associated HCC, underscoring its potential as a therapeutic target. - Source: PubMed
Publication date: 2026/06/09
Di LiangGuo QingliangZhao XiaofeiDing Jing - is indispensable for hematopoiesis, with knockout mice typically exhibiting embryonic lethality attributed to severe anemia and defective hematopoietic stem cell (HSC) development. Intriguingly, we obtained viable adult mice harboring a 17-nucleotide deletion in exon 2, which displayed intact T-cell development despite a significantly reduced bone marrow HSC pool. While mutant HSCs exhibited attenuated lymphoid potential, they retained partial myeloid reconstitution capacity. Single-cell transcriptomic analysis revealed compensatory upregulation of key hematopoietic regulators, including and , in -deficient HSCs. Comprehensive profiling further demonstrated preservation of the complete T-cell hierarchy, including all major subsets, in mutant mice. These findings provide evidence that knockout mice may be viable, and T-cell development may proceed independently of definitive hematopoiesis. - Source: PubMed
Publication date: 2026/05/22
Li YuhangDang ShiyingLi JinbingZhang TianDu JuanPan GuangjinHuang Ke - GATA2 deficiency is a rare genetic disorder with heterogeneous clinical manifestations affecting the immune, hematologic, and vascular systems. We report the case of a 31-year-old woman with primary lymphedema progressing since childhood, associated with diffuse treatment-resistant warts and severe monocytopenia. Genetic testing revealed a mutation in the gene (c.1078T>C), resulting in complete loss of protein function. The patient also exhibited leukopenia and anemia, and bone marrow evaluation confirmed progression to acute myeloid leukemia. The immune deficiencies caused by this mutation explain the increased susceptibility to recurrent infections, particularly persistent human papillomavirus infections responsible for the extensive warts in this patient. The frequent progression to myelodysplastic syndromes and leukemia underscores the severity of this condition and the importance of early diagnosis. Management requires close monitoring, with hematopoietic stem cell transplantation representing the only curative option to improve prognosis and prevent progression to life-threatening complications. This case highlights the need for prompt identification of GATA2 mutations in patients with suggestive clinical features to optimize surveillance and treatment. - Source: PubMed
Publication date: 2026/01/05
Boukamza FirdaoussEl Jouari OuiameHacht FarahLamzouri AfafGallouj Salim - The development of musical abilities, including absolute pitch, musical memory, rhythm sense, and musicality, at a high degree is determined by a hereditary component (up to 68 %). The studies implementing a genome-wide linkage and association approach to musical aptitude have revealed more than 100 genetic loci. This spectrum is comprised of the genes encoding for transcription factors and those responsible for neurogenesis and synaptic plasticity, genes fixed as a result of positive selection of musicality, and those related to inner ear formation. Since no studies linking musical aptitude with genes have been previously conducted in Russia, the present study aimed at replicating the association of 17 previously identified genetic variants with developing musical abilities in Russians. Genotyping of SNPs in the GATA2, PCDH7, UNC5C, ASAP1, SBSPON, DCBLD2, KALRN, VLDLR, OTOF, GRIN2B, FoxP1, FoxP2, BDNF, EGR1, and SNCA genes was performed using competitive allele-specific PCR in a sample of students who underwent rigorous contest selection at admission to the conservatory and in the corresponding control group. A series of logistic regression analyses were used both to evaluate the main effect of SNP and to identify the best prognostic model based on various loci. The mathematical model obtained by including only statistically significant SNPs consisted of GATA2 rs9854612, SNCA rs356168, rs3910105, ASAP1 rs3057, and VLDLR rs1454626 (р = 0.0018, pseudo r2 = 0.188, AUC = 0.791). The addition of all examined SNPs as predictors enabled the construction of a statistically significant model with a higher predictive ability (р = 0.012, pseudo r2 = 0.380, AUC = 0.889). The results revealed indicate a potential cumulative gene effect, confirming the involvement of dopaminergic and GABAergic neurotransmission, the reelin pathway and the role of alpha-synuclein in musicality formation. - Source: PubMed
Kazantseva A VToropova A VKhusnutdinova E KMalykh S B