CXCL12 _ SDF1 (alpha) (recombinant)
- Known as:
- CXCL12 _ SDF1 (a) (Rec.)
- Catalog number:
- AR08009PU-S
- Product Quantity:
- 2 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CXCL12 _ SDF1 (alpha) (recombinant)
Related genes to: CXCL12 _ SDF1 (alpha) (recombinant)
- Gene:
- A4GNT NIH gene
- Name:
- alpha-1,4-N-acetylglucosaminyltransferase
- Previous symbol:
- -
- Synonyms:
- alpha4GnT
- Chromosome:
- 3q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-12
- Date modifiied:
- 2016-10-05
- Gene:
- ABCB5 NIH gene
- Name:
- ATP binding cassette subfamily B member 5
- Previous symbol:
- -
- Synonyms:
- EST422562, ABCB5beta, ABCB5alpha
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2016-10-05
- Gene:
- AGPAT1 NIH gene
- Name:
- 1-acylglycerol-3-phosphate O-acyltransferase 1
- Previous symbol:
- -
- Synonyms:
- LPAAT-alpha
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-07
- Date modifiied:
- 2016-10-05
- Gene:
- AKR1C4 NIH gene
- Name:
- aldo-keto reductase family 1 member C4
- Previous symbol:
- CHDR
- Synonyms:
- DD4, HAKRA, C11, 3-alpha-HSD, CDR, MGC22581
- Chromosome:
- 10p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-08-26
- Date modifiied:
- 2016-06-03
- Gene:
- ARHGEF6 NIH gene
- Name:
- Rac/Cdc42 guanine nucleotide exchange factor 6
- Previous symbol:
- MRX46
- Synonyms:
- alphaPIX, Cool-2, KIAA0006, alpha-PIX, Cool2
- Chromosome:
- Xq26.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-07-27
- Date modifiied:
- 2016-10-05
Related products to: CXCL12 _ SDF1 (alpha) (recombinant)
Related articles to: CXCL12 _ SDF1 (alpha) (recombinant)
- Advancing age is the strongest risk factor for cardiovascular diseases (CVDs), primarily due to progressive vascular endothelial dysfunction. Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related endothelial dysfunction by promoting mitochondrial oxidative stress and inflammation, which reduce nitric oxide (NO) bioavailability. However, the molecular changes in senescent endothelial cells (ECs) and their role in endothelial dysfunction with aging remain unclear. As such, we sought to identify the EC-related signaling pathways, endothelial-associated SASP factors, and their impact on endothelial function with aging. Single-cell transcriptomics was performed on aortas from young (6mos) and old (27mos) female and male mice with and without in vivo senolytic treatment with fisetin (100 mg/kg/day administered intermittently) to characterize EC senescence and transcript expression changes. Circulating levels of SASP factors were measured to assess systemic changes associated with aging and fisetin treatment. Plasma exposure experiments were conducted in isolated mouse arteries and cultured human aortic ECs to determine the causal role of the circulating SASP milieu and specific SASP factors in mediating endothelial dysfunction and underlying mechanisms of action. Senescent ECs exhibited elevated expression of SASP factors, particularly Cxcl12, which was reversed by fisetin supplementation, with responses also reflected in circulating CXCL12 concentrations. Plasma from old mice impaired endothelial function by inducing vascular cell senescence, reducing NO, increasing mitochondrial oxidative stress, shifting receptor and promoting endothelial-to-mesenchymal transition-effects partially driven by CXCL12 and prevented by fisetin. These results identify the SASP and CXCL12 as drivers of age-related endothelial dysfunction and establish mechanisms of senolytic intervention with fisetin supplementation. - Source: PubMed
Mahoney Sophia AMazan-Mamczarz KrystynaTsitsipatis DimitriosVanDongen Nicholas SHenry-Smith Charnae'Okereke Ada NMunk RachelDarvish SannaMurray Kevin ODe SupriyoGorospe MyriamSeals Douglas RRossman Matthew JHerman Allison BClayton Zachary S - The periodontium is a dynamic composite tissue that anchors teeth to the alveolar bone and adapts continuously to mechanical loading and inflammatory challenges throughout life. Its development, homeostasis, and regeneration depend on diverse mesenchymal stem and progenitor cell populations derived from the dental follicle, apical papilla, and periodontal ligament. - Source: PubMed
Publication date: 2026/04/22
Nagata MizukiNagaoka ChikaIwata Takanori - To investigate the impact and mechanism of action of Xiaotan Sanjie (, XTSJ) on the invasiveness and metastasis of gastric cancer (GC) by modulating cancer-associated fibroblasts (CAFs). MKN-45 cells were used in experiments, and an xenograft model was established for further analysis. - Source: PubMed
Ying ZhaoZhenxin ZhuZhihong Y ULijuan XiuYongying LiuYe L UPinkang Wei - High-grade serous ovarian cancer (HGSOC) is the most lethal histological subtype of ovarian cancer, exhibiting significant heterogeneity and limited therapeutic options. A comprehensive characterisation of proteomic landscape across disease stages is needed to identify actionable biomarkers and therapeutic targets. - Source: PubMed
Publication date: 2026/04/18
Tu MengyanTang SangsangZhang QiaoGuo TianchenCen YixuanXu XiaomengWu ShenglongChen XinLu WeiguoDing ChenXu Junfen - The chemokine CXCL12, as a pivotal immune regulator, plays a crucial role in teleost fish against bacterial infection, but current research on its specific mechanisms remains scarce. This study systematically identified two copies of the CXCL12 in turbot (Scophthalmus maximus) (SmCXCL12a and SmCXCL12b), investigated their expression patterns, and revealed their immune functions and antibacterial mechanisms. Firstly, phylogenetic and syntenic analyses indicated that the SmCXCL12a/b were relatively conserved and exhibited high homology with orthologs in other teleost fish, including Japanese flounder (Paralichthys olivaceus). Secondly, of the nine tissues examined in healthy fish, the highest expression level of SmCXCL12a was observed in the kidney, while the highest expression level of SmCXCL12b was detected in the skin. Following infection with Aeromonas salmonicida, significant differential expression of SmCXCL12a and SmCXCL12b was observed in the gills, intestines, and skin. Additionally, both rSmCXCL12a and rSmCXCL12b exhibited chemotactic activity toward kidney macrophages, splenic leukocytes, and peripheral blood leukocytes. Notably, the growth of Escherichia coli and Staphylococcus aureus was inhibited by rSmCXCL12a and rSmCXCL12b. In addition, rSmCXCL12a and rSmCXCL12b exhibited significant binding capacity to multiple Gram-positive and Gram-negative bacteria, with their binding patterns toward bacterial surface substances such as PGN, LPS, LTA, and Poly(I:C). Therefore, it was speculated that they might exert antibacterial functions by recognizing bacterial surface substances. Furthermore, the agglutination properties of rSmCXCL12a and rSmCXCL12b toward various bacteria suggested their capacity to engage with bacterial surface substances. Finally, it was observed that rSmCXCL12a/b could alter the permeability of bacterial cell membranes, resulting in propidium iodide (PI) influx. Meanwhile, changes in membrane potential were detected in DiOC(3) experiments. Hence, it was hypothesized that one of its antibacterial mechanisms could be membrane attack. To conclude, this research thoroughly elucidated the function of the two copies of SmCXCL12 in immune response and antibacterial mechanisms during bacterial infection, providing a theoretical basis for the application of chemokines in the prevention and control of bacterial fish diseases. - Source: PubMed
Publication date: 2026/04/16
Zhang XiaoxuWang BeibeiLiu YiyingZhang PeiChen ChonghuiLi ChaoFu Qiang