GATA3
- Known as:
- GATA3
- Catalog number:
- ARP32548_T100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- GATA3
Related genes to: GATA3
- Gene:
- GATA3 NIH gene
- Name:
- GATA binding protein 3
- Previous symbol:
- -
- Synonyms:
- HDR
- Chromosome:
- 10p14
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-03
- Date modifiied:
- 2016-10-05
Related products to: GATA3
Related articles to: GATA3
- Invasive lobular carcinoma (ILC) is a distinct breast cancer subtype with a characteristic infiltrative growth pattern linked to loss of E-cadherin. GI metastases may clinically and histologically mimic primary GI malignancies, creating significant diagnostic pitfalls. - Source: PubMed
Publication date: 2026/06/12
Sofianidi Amalia APapadimitris ConstantinosPapanikolaou MariaLakiotaki EleftheriaKorkolopoulou PenelopeDimopoulos Meletios-AthanasiosKaparelou Maria - Granular cell tumor of the breast (GCTB) is a rare Schwann-cell-derived neoplasm whose multimodal imaging features overlap extensively with those of invasive carcinoma, frequently exposing patients to unnecessarily extensive surgery in the absence of preoperative tissue diagnosis. We report two institutional cases with detailed imaging-pathology correlation. In Case 1, a 53-year-old postmenopausal woman with a 2.5-cm left axillary tail mass displayed convergent malignant-pattern features across all three imaging modalities - a BI-RADS 5 spiculated mass with skin retraction on mammography, marked posterior acoustic shadowing on ultrasound, and heterogeneous enhancement with a type II (plateau) kinetic curve on contrast-enhanced MRI (a pattern associated with intermediate-to-high suspicion for malignancy) - together with an ipsilateral axillary lymph node demonstrating type III (washout) kinetics. The composite preoperative picture was clinically indistinguishable from cT2N1M0 invasive carcinoma. After the patient declined preoperative core needle biopsy (CNB), breast-conserving surgery and sentinel lymph node biopsy were performed; final pathology confirmed benign GCTB (S-100+, SOX10+, CD68+, Pan-CK-, GATA3-, ER/PR/AR-; 0 of 6 Fanburg-Smith criteria) with reactive nodal hyperplasia. In Case 2, a 38-year-old premenopausal woman with a 0.9-cm right breast nodule underwent ultrasound-guided vacuum-assisted biopsy (VAB) yielding benign GCTB; histology demonstrated tumor cells encircling peripheral nerve bundles within the lesion - direct morphological evidence supporting the established Schwann-cell origin of the tumor. Both patients remained disease-free at 12 and 36 months. These cases reinforce that preoperative CNB with a targeted immunohistochemistry panel - explicitly distinguishing GCTB from ectopic axillary breast carcinoma - should be strongly recommended for any suspicious axillary tail mass; Case 1, in which the patient declined CNB and proceeded directly to surgery, illustrates by counter-example the diagnostic uncertainty that results when this step is omitted. We present these cases in accordance with the CARE reporting guidelines. - Source: PubMed
Publication date: 2026/06/11
Shao YumingXu YangSong ShashaLin HaoZhang Jie - Breast cancer is a leading cause of cancer-related mortality in women, with common metastatic sites including bone, lung, liver, and brain. Metastasis to the gastrointestinal tract, particularly the stomach, is a rare occurrence, with a reported clinical incidence of 0.2-0.7%. Its nonspecific symptomatology and heterogeneous endoscopic presentation often lead to diagnostic confusion with primary gastric cancer or benign conditions. - Source: PubMed
Publication date: 2026/04/27
Khazeam NisreenKhouri Leen IbrahimAlajlani Modar OmarAl-Bitar Ahmad - Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint inflammation, disability, and reduced quality of life. Current mesenchymal stem cell (MSC) therapies face limitations due to cell variability and lack of standardization, highlighting the need for effective, cell-free alternatives that replicate MSCs' immunomodulatory functions. This study aimed to enhance MSC secretion of regulatory factors to modulate inflammation in an RA model. - Source: PubMed
Publication date: 2026/06/29
Mirdamadian Sayed AminAbtahi Froushani Seyyed Meysam M - Patients with advanced non-small cell lung cancer (NSCLC) often experience poor clinical outcomes following chemotherapy. Heat-sensitive moxibustion (HSM), a traditional therapeutic intervention, has been reported to improve symptoms and quality of life in patients with cancer. - Source: PubMed
Publication date: 2026/06/28
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