AFF2 _ FMR2
- Known as:
- AFF2 _ FMR2
- Catalog number:
- ARP34260_P050
- Product Quantity:
- 50 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- AFF2 _ FMR2
Related genes to: AFF2 _ FMR2
- Gene:
- AFF2 NIH gene
- Name:
- AF4/FMR2 family member 2
- Previous symbol:
- FMR2
- Synonyms:
- FRAXE
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-27
- Date modifiied:
- 2019-03-26
Related products to: AFF2 _ FMR2
Related articles to: AFF2 _ FMR2
- DEK::AFF2 fusion-associated nonkeratinizing squamous cell carcinoma is a recently recognized HPV-independent entity characterized by deceptively bland morphology and potential mimicry of benign or inflammatory lesions. - Source: PubMed
Publication date: 2026/06/19
Li YanMa LinxiangYang WenlinZhang RenyaWang Ting - Sinonasal squamous cell carcinoma (SNSCC) is a rare malignancy with variable outcomes, and the prognostic impact of molecular alterations remains incompletely defined. This meta-analysis aims to clarify the associations of genetic alterations and protein expression with clinical outcomes in SNSCC. - Source: PubMed
Publication date: 2026/06/01
Vasudevan Srivatsa SuryaCradeur AmberPolson MadelineNathan Cherie-Ann OAhmed Omar GYim Michael T - PURPOSE: Sinonasal papilloma (SP) has a recognized potential for malignant transformation, most commonly into squamous cell carcinoma (SCC). Well-established criteria for malignancy are lacking in SP and often depends on subjective features, such as stromal invasion without desmoplasia or assessment of dysplastic epithelium-to-stroma ratio, which can lead to under- or over-diagnosis, particularly in small biopsies. Additionally, emerging entities that mimic dysplastic papillomas necessitate re-evaluation of previously diagnosed “atypical/dysplastic SP” cases. METHODS: We conducted a retrospective study of 270 SP cases (226 patients) from 01/2010 to 06/2024. Three patients initially reported as “atypical and/or dysplastic SP”, “low-grade papillary sinonasal carcinoma”, and “papillary SCC”, were later found to harbor a DEK::AFF2 fusion were excluded from the study. RESULTS: In all, malignant transformation was identified in 17/226 (7.5%) SP patients (including 14/202 (6.9%) inverted papilloma and 3/12 (25%) oncocytic papilloma), of which nine were synchronous and eight were metachronous transformations. Resultant malignancies comprised of SCC (14/17; 82.3%), sinonasal adenocarcinoma (SNAC) (1/17; 5.9%), dedifferentiated squamous cell carcinoma (1/17; 5.9%), and adenosquamous carcinoma (ASC) (1/17; 5.9%). Molecular profiling identified EGFR and KRAS as primary driver mutations, with additional TP53 and CDKN2A loss-of-function alterations implicated in malignant transformation. Immunohistochemical patterns of p53 (overexpression/null) and loss of p16 expression correlated with underlying genetic alterations (TP53 and/or CDKN2A), suggest these can act as surrogate markers for malignant transformation and may aid in risk stratification. Interestingly in our study, among the three oncocytic papillomas with malignant transformation, one showed ASC with transcriptionally active high-risk HPV and a concurrent KRAS mutation, and another transformed into non-intestinal-type SNAC. CONCLUSION: Malignant transformation in SP occurs almost exclusively in IP and OP, warranting comprehensive evaluation of dysplastic SPs to exclude unsampled malignancy and newly defined molecular subsets. HPV appears to play role in malignant transformation. p53 and p16 immunostaining may help in dysplastic SP and guide closer clinical surveillance. - Source: PubMed
Publication date: 2026/04/20
Amin Sara ESono ReiriAl-Jumaili Zubaidah IAk SibelHang Jen-FanElsayad MahmoudSaluja Karan - An increased understanding of molecular alterations over the last decade has also impacted the landscape of sinonasal squamous cell carcinoma (SNSCC). In addition to traditional SCC risk factors (e.g. smoking) and high-risk HPV (HR- HPV), other drivers are emerging, such as DEK::AFF2 fusion in non-keratinizing and papillary SNSCC. Treatment of squamous cell carcinoma has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. We describe a case report of nasal nonkeratinizing squamous cell carcinoma- HPV-high risk (HPV-HR) positive and harboring an MKRN1::BRAF fusion. We further discuss the significance of these findings, integrated in the context of current literature. - Source: PubMed
Publication date: 2026/03/13
Bell DianaWang Eric WChoby GarretSnyderman CarlArivarasan KarunamurthySeethala Raja R - piRNAs (PIWI-interacting RNAs) can significantly modify the expression of protein-coding genes by suppressing the translation process. The aim of this work was to computationally evaluate the potential interactions between piRNAs and the mRNA of the gene, as well as other genes involved in key metabolic pathways related to health and lifespan regulation. - Source: PubMed
Publication date: 2026/02/18
Pyrkova AnnaAkhmetova KyrmyzyZhanuzakov MuratTauassarova MakpalRakhmetulina AizhanNiyazova RaigulOrazova SaltanatZielenkiewicz PiotrIvashchenko Anatoliy