CYP4A22
- Known as:
- CYP4A22
- Catalog number:
- ARP41862_P050
- Product Quantity:
- 50 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CYP4A22
Related genes to: CYP4A22
- Gene:
- CYP4A22 NIH gene
- Name:
- cytochrome P450 family 4 subfamily A member 22
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-05
- Date modifiied:
- 2018-11-15
Related products to: CYP4A22
Related articles to: CYP4A22
- Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep and is frequently accompanied by dyslipidemia. However, the molecular mechanisms linking lipid metabolism to OSA remain incompletely understood. This study aimed to investigate the association between blood lipid levels and OSA and explore potential underlying molecular pathways. - Source: PubMed
Publication date: 2026/06/21
Liu YanhuiGong SisiWang JiaqiChen ShanshanZeng YimingFan Chunmei - Pediatric bone sarcomas, including osteosarcoma (OS) and Ewing sarcoma (ES), are aggressive malignancies with poor prognosis in the metastatic stage. Oxylipins, bioactive lipid mediators derived from polyunsaturated fatty acids (PUFAs), play a crucial role in inflammation, immunity, and cancer progression; however, their systemic profiles in pediatric sarcomas remain unexplored. - Source: PubMed
Publication date: 2026/05/23
Chistyakov D VNikolskaya A IGorbatenko V OGoriainov S VPrishchep P LKuzmin Yu BAlferov A AKuznetsov I NVarfolomeeva S RStilidi I SKushlinskii N ESergeeva M G - Gastric cancer (GC) prognosis remains poor, necessitating reliable biomarkers. Disulfidptosis represents a promising therapeutic frontier. This study aimed to construct a prognostic model based on disulfidptosis-related LncRNAs (DRLs) and investigate their function. - Source: PubMed
Publication date: 2026/05/20
Li NameiTong ZhongyiShe Xiaoling - Cervical cancer (CC) remains a common malignant tumor that seriously threatens women's health globally. Gramine (GR), a natural alkaloid derived from plants such as L., exhibits anti-tumor activities, yet its mechanistic actions in CC are still unclear. Here, we integrated cell-based assays, network pharmacology, and multi-omics analysis to systematically investigate the molecular mechanisms underlying GR's anti-CC effects. In vitro experiments showed that GR significantly inhibited proliferation and migration, induced apoptosis, and triggered G/G phase cell cycle arrest in HeLa cells. Integrated multi-omics analysis identified CDK2 as a critical target of GR, with both mRNA and protein levels markedly reduced following treatment. Mechanistically, GR likely suppresses CC progression by modulating the "CYP4A22-AS1/LINC00958-hsa-miR-133b-CDK2" competitive endogenous RNA (ceRNA) axis. Immune analysis indicated positive correlations of CDK2, CYP4A22-AS1, and LINC00958 with the immune checkpoint molecule CD47. Collectively, our findings demonstrate that GR inhibits CC through a ncRNA-mediated suppression of CDK2, leading to reduced HeLa cell proliferation and migration and enhanced apoptosis. These results provide a mechanistic rationale for developing GR as a candidate agent for targeted therapy and immuno-combination strategies in CC. - Source: PubMed
Publication date: 2026/01/06
Zhou ZhiyanLi JinZhao XingjiXu HongxiaXiao YuWang HongchenChen Ying - Beef flavor is affected by muscle metabolites and their related regulatory genes, and the molecular regulatory mechanisms vary among different beef breeds. To provide some new ways to improve meat quality and cattle breed improvement, 24-month-old ( = 8) and yellow cattle ( = 8) were selected for comparison in this study. The result revealed that the longissimus dorsi muscle fiber diameter, protein content and a-value of were significantly higher than that of yellow cattle, but the fat content was lower than that of yellow cattle. Furthermore, meat contained notably higher levels of polyunsaturated fatty acids (PUFA) and n-3PUFA than that of yellow cattle, and also had better levels of flavor amino acids (FAAs) and sweet amino acids (SAAs), which contribute to the flavor of beef. Through comprehensive analysis of transcriptomics and metabolomics, we detected a total of 109 markedly different metabolites (DEMs) and 1,677 differentially expressed genes (DEGs) in the pectoral muscles of the two breeds. Further analysis indicated that amino acid and lipid metabolism might be the key factors contributing to the differences in meat quality and flavor between and yellow cattle, involving metabolites such as L-2-aminobutyric acid, L-glutamic acid, L-glutamine, L-serine, betaine, pantothenic acid, and taurine. Through correlation analysis, we identified genes highly associated with flavor amino acids (, ), muscle development (, , ), and lipid metabolism (, , , , , 3, , , ) related essential regulatory genes and constructed a gene-metabolite interaction network for meat quality and flavor formation in . In summary, it was shown that significant differences in muscle metabolites between and yellow cattle, especially in amino acid and lipid metabolism, may be the major reason for the differences in quality and flavor between the two types of beef. This study provides a theoretical basis for further exploring the molecular regulatory mechanisms of the differences in beef quality and flavor between and yellow cattle, and provides a reference for the development and genetic breeding of high-quality cattle breeds. - Source: PubMed
Publication date: 2025/05/14
Han LinFu RunqiFu BinlongLi QianYu YeGao HuanZhang JiaweiQi MinJin ChunjiaMao ShengyongLeng Jing