ESRRG Western Blot Kit
- Known as:
- ESRRG Western Blot Kit
- Catalog number:
- ARPK31655_T100
- Product Quantity:
- 25 Western Blots
- Category:
- -
- Supplier:
- ACR
- Gene target:
- ESRRG Western Blot Kit
Related genes to: ESRRG Western Blot Kit
- Gene:
- ESRRG NIH gene
- Name:
- estrogen related receptor gamma
- Previous symbol:
- -
- Synonyms:
- NR3B3, ERRg, ERR-gamma
- Chromosome:
- 1q41
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-17
- Date modifiied:
- 2018-02-14
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- Ziyuglycosides I-II are two glycosylated triterpenoids isolated from the edible medicinal plant Sanguisorba officinalis L. (great burnet). Ziyu-1 is a bidesmosidic saponin whereas its metabolite Ziyu-2 is a monodesmoside. They were initially isolated from the plant roots (Sanguisorbae radix) but they can be found in diverse medicinal plants and polyherbal preparations. This review retraces the origin of the products, discusses synthetic processes to obtain derivatives from the sapogenin precursor pomolic acid, and presents an overview of the pharmacological properties of Ziyu-1/2. The natural products display antitumor properties, with six major anticancer targets identified, including receptor ESRRG, chromobox protein CBX4 and endoplasmic reticulum-associated protein STING, implicated in tumor cell proliferation and immune-regulation. In parallel, anti-inflammatory properties have been evidenced, associated with the targeting of a few other protein targets such as ADP ribosyl cyclase CD38. Altogether, a dozen protein targets have been proposed, mainly based on in silico studies. The interest of the products for skin protection, as cosmeceutical ingredients, and their antibacterial and antiviral effects are also evoked. Formulation products (Ziyu liposomes and nanoparticules) and (hemi)synthetic analogues are discussed. The aim of this study is to promote further researches with these triterpenoids and naturally-occurring or hemisynthetic analogues. - Source: PubMed
Publication date: 2026/07/22
Bailly Christian - Given the existing uncertainties regarding the link between Di(2-ethylhexyl) phthalate (DEHP) exposure and gastric cancer (GC) progression, this study aimed to clarify their association, identify the toxic targets of DEHP, and elucidate the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/07/16
Li ShenghaoPeng QingHao LiyuanMao JingyuHuo Bingjie - Breast cancer (BRCA) is a common malignant tumor that seriously threatens women's health. Studies have shown that histone modifications (HMs) play a vital role in the occurrence and development of BRCA. This study aims to explore the distribution patterns of HMs in the mammary epithelial cell line (HMEC) and breast cancer cell line (MCF-7), and their potential associations with gene expression, patient prognosis, and drug efficacy. - Source: PubMed
Publication date: 2026/06/01
Cao YanniLi XiaohuiLiu JiangshanZhang JunyuanXu KangchengLin HaoLiu Yuxian - The estrogen-related receptor (ERR) family, comprising ESRRA (estrogen-related receptor alpha), ESRRB (estrogen-related receptor beta), and ESRRG (estrogen-related receptor gamma), plays a crucial role in regulating metabolic and developmental processes. However, the functional significance of ERRs during preimplantation embryo development remains largely unclear. In the present study, we aimed to systematically characterized ERRs expression dynamics in mouse preimplantation embryo development and elucidated the mechanistic involvement of ERRs in blastocyst formation. Our findings demonstrate that among the estrogen-related receptor family, ESRRG is uniquely and highly expressed at the 2-cell embryo stage and is essential for blastocyst formation. Knockdown of Esrrg significantly reduced global transcriptional activity in the 2-cell embryos, thereby impairing zygotic genome activation (ZGA) and disrupting the 2-cell to 4-cell embryo transition. Given the crucial role of ESRRG in ZGA, the mechanisms governing its own transcriptional regulation are of paramount interest. To this end, we searched for upstream regulators and identified trichorhinophalangeal syndrome I (TRPS1) as a key transcription factor that directly binds to the Esrrg promoter to modulate its expression. Furthermore, the TRPS1-ESRRG regulatory axis orchestrates mouse preimplantation development by controlling the expression of critical ZGA factors, such as Sp1 transcription factor and tankyrase 2. These results establish the TRPS1-ESRRG axis as a critical regulator of mouse preimplantation development through its essential role in modulating zygotic genome activation. - Source: PubMed
Publication date: 2026/06/04
Sun JiandongLiao ShuminLin ZihangLian XiuliXu WeiweiLiu YueWang XuanyiLin ZeyuZhang DiniWang Shie - 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) is a key placental steroidogenic enzyme that converts estrone to estradiol. Prior studies have suggested that reduced placental or circulating HSD17B1 is associated with preeclampsia (PE), but its position within the broader transcriptomic landscape and its relationship to immune changes remain incompletely characterized. - Source: PubMed
Publication date: 2026/05/29
Ling KengHong MinpingJin LiqinLing AiWang Jianguo