CD95 _ FAS (inducing)

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766.72 €

Known as:: CD95 _ Fas Cell Surface Death Receptor (inducing)
Catalog number:: BM2616
Product Quantity:: 0.1 mg
Category:: -
Supplier:: ACR
Gene target:: CD95 _ FAS (inducing)

Related genes to: CD95 _ FAS (inducing)

Gene:: FAS ^{NIH gene}
Name:: Fas cell surface death receptor
Previous symbol:: FAS1, APT1, TNFRSF6
Synonyms:: CD95, APO-1
Chromosome:: 10q23.31
Locus Type:: gene with protein product
Date approved:: 1992-06-25
Date modifiied:: 2019-04-23

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Degraded sulfated galactan derived from induces immunogenic cell death in MDA‑MB‑231 cells.
Sulfated galactan (SG) isolated from has demonstrated promise for cancer therapy and prevention through inhibition of cancer cell proliferation and migration. However, its structure‑activity relationship remains to be elucidated. The present study evaluated the microstructural characteristics and anticancer activity, particularly immunogenic cell death (ICD)‑inducing potential, of SG and its degraded derivative (DSG) in triple‑negative breast cancer cells. SG and DSG were prepared and structurally characterized using gel permeation chromatography, nuclear magnetic resonance, Fourier‑transform infrared and scanning electron microscopy coupled with energy‑dispersive X‑ray spectroscopy. ICD induction was assessed in human MDA‑MB‑231 breast cancer cells using an MTT assay, phase‑contrast microscopy, Hoechst/propidium iodide dual staining, intracellular reactive oxygen species (ROS) generation assay, and transmission electron microscopy (TEM). In addition, western blot analysis, immunofluorescence staining, and reverse transcription‑quantitative PCR were performed. Structural analyses revealed that SG and DSG share similar backbone structures but differ markedly in sulfate content and molecular weight. Both compounds were non‑toxic to normal breast epithelial MCF‑10A cells and exhibited mild cytotoxicity toward MDA‑MB‑231 cells. DSG treatment induced notable morphological changes in cancer cells, with reduced cell numbers, increased membrane permeability and elevated intracellular ROS levels. TEM revealed DSG‑induced ultrastructural changes consistent with cellular stress and cytotoxicity. DSG also markedly upregulated ICD‑associated proteins [calreticulin (CRT) and Fas receptor (Fas‑R)] and endoplasmic reticulum stress‑related genes (protein kinase RNA‑like endoplasmic reticulum kinase, inositol‑requiring enzyme 1, activating transcription factor (ATF)6, ATF4, eukaryotic initiation factor 2 α subunit, CRT and Fas‑R), with effects similar to the positive control doxorubicin. Therefore, these findings indicated that DSG enhances ICD in triple‑negative breast cancer cells and may potentially serve as a promising ICD‑inducing adjuvant for cancer immunotherapy. - Source: PubMed
Publication date: 2026/06/19
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Topological materials have been reported as active and selective electrochemical catalysts for a variety of small-molecule energy-conversion reactions. The exceptional activity and selectivity of these materials have been attributed to their topologically non-trivial surface states, which support chiral spin currents and boast high carrier mobilities. For the topological semimetal PtGa, we find that these states are not robust under practical electrochemical conditions. During electrochemical operation, Ga rapidly corrodes from the surface, yielding a nanoporous, Pt-rich layer. Inductively coupled plasma mass spectrometry and scanning transmission electron microscopy imaging independently confirm Ga corrosion. Hydrogen evolution reaction activity measurements demonstrate that the electrocatalytic performance of PtGa is correlated with the number of Pt active sites, and first-principle calculations further show that introducing Ga vacancies into the PtGa crystal structure disrupts the topologically non-trivial surface states. These observations suggest that previous reports detailing the high electrochemical activity of PtGa might be better explained by an enrichment in Pt active sites following corrosion, rather than by a genuine increase in the intrinsic reaction rate mediated by PtGa's topological surface states. These results urge caution in attributing enhanced catalytic activity to topological surface states without verifying surface composition and electronic structure. They also highlight the distinct meaning of robustness in physics and chemistry. - Source: PubMed
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METTL7A is a key regulator of hepatic lipid metabolism and nonalcoholic fatty liver disease progression.
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CD95 _ FAS (inducing)

Related genes to: CD95 _ FAS (inducing)

Related products to: CD95 _ FAS (inducing)

Related articles to: CD95 _ FAS (inducing)

Video-Based Training on Physicians' Proficiency in Invasive Fungal Disease: A Multicentre, Cluster Randomised Controlled Trial.

Degraded sulfated galactan derived from induces immunogenic cell death in MDA‑MB‑231 cells.

Revisiting the origin of electrochemical activity in the topological semimetal PtGa.

Docetaxel enhances Vβ-directed T-cell activation and antitumor immunity mediated by a bifunctional TCR agonist in breast and prostate cancer models.

METTL7A is a key regulator of hepatic lipid metabolism and nonalcoholic fatty liver disease progression.