Protein Tyrosine Phosphatase (PTP) PTPRA
- Known as:
- Protein Tyrosine Phosphatase (PTP) PTPRA
- Catalog number:
- E-3301
- Product Quantity:
- 20 ug
- Category:
- -
- Supplier:
- Bioner
- Gene target:
- Protein Tyrosine Phosphatase (PTP) PTPRA
Related genes to: Protein Tyrosine Phosphatase (PTP) PTPRA
- Gene:
- ACP1 NIH gene
- Name:
- acid phosphatase 1
- Previous symbol:
- -
- Synonyms:
- HAAP, LMW-PTP, LMWPTP
- Chromosome:
- 2p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-09-15
- Gene:
- DUSP1 NIH gene
- Name:
- dual specificity phosphatase 1
- Previous symbol:
- PTPN10
- Synonyms:
- HVH1, CL100, MKP-1
- Chromosome:
- 5q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-03
- Date modifiied:
- 2015-09-11
- Gene:
- HACD1 NIH gene
- Name:
- 3-hydroxyacyl-CoA dehydratase 1
- Previous symbol:
- PTPLA
- Synonyms:
- CAP
- Chromosome:
- 10p12.33
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-22
- Date modifiied:
- 2016-01-15
- Gene:
- HACD2 NIH gene
- Name:
- 3-hydroxyacyl-CoA dehydratase 2
- Previous symbol:
- PTPLB
- Synonyms:
- -
- Chromosome:
- 3q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-22
- Date modifiied:
- 2016-01-15
- Gene:
- HACD3 NIH gene
- Name:
- 3-hydroxyacyl-CoA dehydratase 3
- Previous symbol:
- PTPLAD1
- Synonyms:
- B-ind1, HSPC121
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-11
- Date modifiied:
- 2016-01-15
Related products to: Protein Tyrosine Phosphatase (PTP) PTPRA
Related articles to: Protein Tyrosine Phosphatase (PTP) PTPRA
- L-amino acid oxidase (LAAO) has been found to play an important role in fish immune function in recent years. It has been reported to have broad-spectrum antibacterial, anti-parasitic and other immune activities. Our previous study found that LAAO had significant killing activity against Streptococcus agalactiae in vitro. This study investigated the in vivo regulatory mechanism of LAAO in the S. agalactiae infection process in teleost fish. A zebrafish model with LAAO gene knockout was generated by CRISPR/Cas9 technology. Transcriptome analysis was performed on the liver and gill tissues of LAAO (-/-) and wild-type zebrafish under normal conditions and 12 h after challenge with 2 × 10 CFU/mL S. agalactiae. The results showed that the ability of zebrafish to resist S. agalactiae infection was significantly reduced after LAAO gene knockout. In the liver of LAAO (-/-) and wild-type zebrafish, the most highly up-regulated genes were chia.3, chia.1, chia.2 and ctrl; the most down-regulated genes were vtg4, vtg7 and vtg6. In gill, ptpra, nono and ptx3a were the most up-regulated genes, scpp5 and slc24a2 were the most down-regulated genes. The most up-regulated and down-regulated genes in the liver and gill after challenge were ctsba and mhc1uba. Regardless of infection status, both tissues showed enrichment in amino acid metabolism and synthesis-related pathways, carbohydrate metabolism-related pathways, and lipid-related pathways. Differentially expressed genes (DEGs) associated with immune pathways were enriched in the PPAR signaling pathway, peroxisome pathway and glutathione metabolism pathway. The results of this study provide a reference for the molecular regulation mechanism of LAAO in fish. - Source: PubMed
Publication date: 2026/08/20
Qi WenxuZhang ZiyiHuang YuxiZhao ShuqiLiu HaoLi Ruijun - This article provides a comprehensive review of the molecular and neurodevelopmental mechanisms underlying schizophrenia, with a particular focus on the roles of protein tyrosine phosphatases (PTPs). Schizophrenia is a neurodevelopmental disorder with a complex etiology involving genetic and environmental factors and characterized by diverse clinical symptoms. The review synthesizes recent advances in understanding how dysregulation of specific PTPs, including PTP1B, PTP receptor gamma (PTPRG), PTPN5 (encoding striatal-enriched PTP [STEP]), and PTP receptor type A (PTPRA), contributes to disrupted synaptic signaling, neurotransmitter dysfunction, and neurodevelopmental abnormalities observed in schizophrenia. Key findings include evidence that altered phosphorylation states, impaired myelination, and aberrant modulation of N-methyl-D-aspartate (NMDA) and dopamine receptor function are central to disease pathophysiology. The review also examines the therapeutic potential of targeting PTP1B and other phosphatases, highlighting promising animal model data while emphasizing the need for additional clinical research. Collectively, the article underscores the importance of phosphatase signaling pathways in the pathogenesis and potential treatment of schizophrenia. - Source: PubMed
Publication date: 2026/01/27
Murugesan KarthikaRebellow DelvyKasagga AlousiousMon Aye MAnwar Summayya - [This retracts the article DOI: 10.3892/etm.2021.10711.]. - Source: PubMed
Publication date: 2025/12/01
Jin YanlinZhang YiLuo Xiaoming - The Xinjiang Uygur Autonomous Region of China is characterized by unique genetic and environmental factors, influenced by its geography, culture, and interethnic interactions. Understanding lipid metabolism in this population may help identify novel genetic regulators relevant to cardiovascular risk. An extreme phenotype sequencing strategy was applied to Han Chinese university students from Xinjiang. Individuals with extremely low triglyceride (TG) levels and those with normal TG levels were selected. Whole-exome sequencing was conducted, followed by bioinformatics filtering and variant prioritization based on frequency, predicted function, and phenotypic relevance. A total of 10 candidate genes (ACTN2, DHTKD1, NLRP9, PTPRA, INPP4B, PHGDH, PYROXD2, RIN1, MYRIP, and PRSS57) were identified as potentially involved in lipid metabolism regulation. Several of these genes are implicated in metabolic signaling pathways or cellular lipid processing. This study provides new insights into the genetic architecture of lipid metabolism among Han Chinese youth in Xinjiang. The identified genes warrant further validation through functional studies to elucidate their roles and potential as therapeutic targets for dyslipidemia. - Source: PubMed
Yu JiaqingMa Yitong - - Source: PubMed
Luo XuetingZhou Xiaoli