CAPS
- Known as:
- CAPS
- Catalog number:
- 07116-74
- Product Quantity:
- 100 g
- Category:
- -
- Supplier:
- Nacala
- Gene target:
- CAPS
Related genes to: CAPS
- Gene:
- CADPS NIH gene
- Name:
- calcium dependent secretion activator
- Previous symbol:
- -
- Synonyms:
- CAPS, KIAA1121, CAPS1, UNC-31
- Chromosome:
- 3p14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-21
- Date modifiied:
- 2016-10-05
- Gene:
- CADPS2 NIH gene
- Name:
- calcium dependent secretion activator 2
- Previous symbol:
- -
- Synonyms:
- CAPS2
- Chromosome:
- 7q31.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-12
- Date modifiied:
- 2016-06-08
- Gene:
- CAPS NIH gene
- Name:
- calcyphosine
- Previous symbol:
- -
- Synonyms:
- CAPS1, MGC126562
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-31
- Date modifiied:
- 2016-07-18
Related products to: CAPS
(3-[CYCLOHEXYLAMINO]-1-PROPANE, SULPHONIC ACID) (CAPS BUFFER) extrapure(3-[CYCLOHEXYLAMINO]-1-PROPANE, SULPHONIC ACID) (CAPS BUFFER) extrapure.2ml 12-Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12-Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12-Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12-Well PCR Strip Tubes Strip Dome Caps Included.2ml 12-Well PCR Strip Tubes Strip Dome Caps Included.2ml 12-Well PCR Strip Tubes Strip Dome Caps Included.2ml 12-Well PCR Strip Tubes Strip Dome Caps Included.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Strip Dome Caps Included Related articles to: CAPS
- The Ca-dependent activator protein for secretion (CAPS/CADPS) family protein facilitates catecholamine release through the dense-core vesicle exocytosis in model neuroendocrine cell lines. However, it remains unclear if it induces dopamine release in the central neurons. This study aimed to examine the expression and function of CADPS2, one of the two CADPS paralogs, in dopamine neurons of the mouse midbrain. This study shows that CADPS2 was expressed in tyrosine hydroxylase and the vesicular monoamine transporter 2 (VMAT2)-positive dopaminergic neurons of the midbrain samples and primary mesencephalic cell cultures. Subcellular fractions rich in dopamine were collected using immunoaffinity for CADPS2 from midbrain protein extracts. Cell imaging using fluorescent false neurotransmitter FFN511 as a substrate for VMAT2 showed decreased activity-dependent dopamine release in -deficient cultures, compared to that in wild-type cultures. These results suggest that CADPS2 is involved in dopamine release from the central neurons, indicating its involvement in the central dopamine pathway. - Source: PubMed
Publication date: 2024/07/18
Iguchi HirotoshiKatsuzawa TakumiSaruta ChihiroSadakata TetsushiKobayashi ShotaSato YumiSato AkiraSano YoshitakeMaezawa SoShinoda YoFuruichi Teiichi - The Ca-dependent activator protein for secretion 2 (CADPS2) is a member of the CAPS/CADPS protein family that plays crucial roles in synaptic vesicle dynamics. Genomic variability in the CADPS2 gene has been associated to autism spectrum disorders and Alzheimer's disease, both characterized by altered neurotransmission. Biological evidence also linked CADPS2 to Parkinson's disease (PD), as a disease-causing mutation in leucine-rich repeat kinase 2 (LRRK2) was reported to increase CADPS2 gene and protein expression. Furthermore, restoration of CADPS2 physiologic levels was able to provide neuroprotection in patient-derived neurons, consistent with the synaptic dysfunction postulated to underlie PD. However, little is known about the influence of PD-related proteins on transcriptional regulation of critical synaptic genes such as CADPS2. Here we aimed at investigating the transcriptional effects of LRRK2 and alpha-synuclein (aSyn) on CADPS2 gene expression, using a combination of in silico analyses and cell biology techniques. First, we identified a predicted promoter in the human CADPS2 genomic sequence, which we then utilized in a luciferase-based gene reporter assay. This approach enabled us to disclose a differential effect of high levels of LRRK2 and aSyn on CADPS2 promoter activity. Specifically, CADPS2 transcriptional activity was enhanced by high cellular levels of LRRK2 and reduced by overexpression of aSyn. Consistently, CADPS2 mRNA levels were diminished in aSyn overexpressing cells. Our results indicate that LRRK2 and aSyn participate in the dysregulation of CADPS2 by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as PD. - Source: PubMed
Publication date: 2017/06/21
Obergasteiger JuliaÜberbacher ChristaPramstaller Peter PHicks Andrew ACorti CorradoVolta Mattia - The family of Ca2+-dependent activator proteins for secretion (CAPS) is involved in dense-core vesicle exocytosis. CAPS1/CADPS1 and CAPS2/CADPS2 have been identified in mammals. CAPS1 regulates catecholamine release from neuroendocrine cells, whereas CAPS2 is involved in the release of brain-derived neurotrophic factor and neurotrophin-3 from cerebellar granule cells. CAPS1 and CAPS2 are predominantly expressed in brain. Here we show the immunohistochemical localization of the CAPS family proteins in various mouse tissues. In the pituitary gland, CAPS1 and CAPS2 were localized to the pars nervosa and the pars intermedia, respectively. In non-neural tissues, CAPS1 was observed in the islets of Langerhans, minor cell types of the spleen and stomach, and medullary cells of the adrenal gland, whereas CAPS2 was present in bronchial epithelial cells, thyroid parafollicular cells, chief cells of the stomach, ductal epithelium of the salivary gland, kidney proximal tubules, and minor cell types of the thymus, spleen, and colon. These results suggest that secretion from distinct cell types in various tissues involves either or both members of the CAPS family. - Source: PubMed
Publication date: 2006/12/12
Sadakata TetsushiWashida MiwaMorita NoriyukiFuruichi Teiichi