Fluoro AChE
- Known as:
- Fluoro AChE
- Catalog number:
- AChE100-2
- Product Quantity:
- 100 tests
- Category:
- -
- Supplier:
- Celleng-tech
- Gene target:
- Fluoro AChE
Related genes to: Fluoro AChE
- Gene:
- ACHE NIH gene
- Name:
- acetylcholinesterase (Cartwright blood group)
- Previous symbol:
- YT
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-02
- Date modifiied:
- 2019-04-23
Related products to: Fluoro AChE
(+)-5-Fluoro-2'-deoxyuridine (+)-5-Fluoro-2'-deoxyuridine For research use only.(-)-β-D-Dioxolane-5-fluoro Cytidine C8H10FN3O4 CAS: 145397-26-8(-)-β-D-Dioxolane-5-fluoro Cytidine CAS: 145397-26-8 Formula: C8H10FN3O4(11β)-21-Chloro-9-fluoro-11-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione C22H26ClFO3 CAS: 1356190-17-4(11β)-21-Chloro-9-fluoro-11-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione CAS: 1356190-17-4 Formula: C22H26ClFO3(11β,16α)-21-(Acetyloxy)-9-fluoro-11,16,17-trihydroxy-pregna-1,4,14-triene-3,20-dione C23H27FO7 CAS: 131918-74-6(11β,16α)-21-(Acetyloxy)-9-fluoro-11,16,17-trihydroxy-pregna-1,4,14-triene-3,20-dione CAS: 131918-74-6 Formula: C23H27FO7(11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione-d2 3,20-Dioxime C21H27D2FN2O6 CAS:(11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione-d2 3,20-Dioxime CAS: Formula: C21H27D2FN2O6(11β,16α)-9-Fluoro-11,21,21-trihydroxy-16,17-[(1-methylethylidene)bis(oxy)]
pregna-1,4-diene-3,20-dione CAS: 161740-69-8 Formula: C24H31FO7(11β,16α)-9-Fluoro-16,17,21-trihydroxyl-pregna-1,4-diene-3,11,20-trione 3,20-Dioxime C21H27FN2O6 CAS:(11β,16α)-9-Fluoro-16,17,21-trihydroxyl-pregna-1,4-diene-3,11,20-trione 3,20-Dioxime CAS: Formula: C21H27FN2O6(11β,16α,20R)-9-Fluoro-11,20-dihydroxy-16-methyl-3-oxopregna-1,4-dien-21-oic Acid C22H29FO5 CAS: 50764-01-7(11β,16α,20R)-9-Fluoro-11,20-dihydroxy-16-methyl-3-oxopregna-1,4-dien-21-oic Acid CAS: 50764-01-7 Formula: C22H29FO5(11β,16α,20S)-9-Fluoro-11,20-dihydroxy-16-methyl-3-oxopregna-1,4-dien-21-oic Acid C22H29FO5 CAS: 50764-02-8 Related articles to: Fluoro AChE
- This study comparatively evaluated the phytochemical composition and bioactivities of methanolic extracts and aqueous decoctions obtained from seeds of two Fabaceae taxa (Gonocytisus angulatus, Podocytisus caramanicus). Aqueous decoction yielded higher extraction efficiencies (up to 39.20%), whereas methanolic extraction recovered a broader range of phenolic compounds. Phytochemical analysis revealed that flavonoids and phenolic acids were the dominant constituents, with chlorogenic acid, rutin, quercetin, kaempferol, and gallic acid as the major compounds, particularly enriched in methanolic extracts. In vitro assays demonstrated moderate enzyme inhibitory effects. The highest α-glucosidase inhibition was observed in the methanolic extract (20.22%), while α-amylase inhibition reached 30.11%. Anticholinesterase activity was also weak, with maximum acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition values of 15.27% and 19.93%, respectively. In contrast, antioxidant activity was more pronounced, with ABTS radical scavenging reaching 97.40%, comparable to the reference standard. Molecular docking supported these findings by indicating favorable binding interactions of major phenolic compounds with target enzymes. - Source: PubMed
Bayrak BurakGüneş FerhatAkyüz BeyzanurBeyza Özer ElifAbdulqader Amenah ImadÇivaş AyşeKüçüksu İsranurSönmez Hatice RümeysaÇeçen ÖmerAydın BilgeÇoban FurkanYuca HafizeKarakaya Songül - Pain assessment often follows a hierarchy: self-report is treated as the gold standard, while behavioural and physiological evidence are used when the report is unavailable. This protects patients against professional disbelief but can make those unable to self-report appear unable to contribute to knowledge about their pain. I argue that verbal report and nonverbal expression belong to one interpretive practice while retaining different epistemic roles. Self-report carries presumptive first-person authority because it conveys experience, meaning, and preferences. Behavioural evidence is indirect, context-dependent, and fallible, but it is genuine evidence. Physiological evidence is less specific and should remain an adjunct. When self-report is unavailable, what changes is not the kind of pain a patient may have but the evidence available and what it can justify. Drawing on the social communication model of pain, nursing accounts of tacit and relational knowledge, phenomenology, and epistemic injustice, I use functional distress to name an organised pattern of clinically significant change. The functional-distress framework explains when that pattern supports suspicion of pain. It is not another assessment instrument; it shows how clinicians combine validated tools with timing, relationships, clinical context, alternative explanations, and reassessment. Functional distress does not prove pain. It can provide reversible grounds for suspicion; separately, risk, vulnerability, and reversibility may justify a proportionate precautionary response. The ethical task is to preserve first-person authority without treating patients who cannot exercise it as epistemically absent. - Source: PubMed
Blenis R Colin - Peripherally restricted analgesics devoid of central side effects are urgently needed for postoperative pain management. The cannabinoid type-1 receptor (CBR) expressed on primary sensory neurons represents an attractive peripheral target, yet its specific role and mechanism in postoperative pain remain poorly defined. Here, by constructing a mouse model of plantar incision and combining with nociceptor-selective Cnr1 knockout and site-specific pharmacology, we revealed that activation of CBR in primary sensory neurons robustly alleviates postoperative mechanical allodynia. Peripheral CBR co-localizes and physically associates with the proton-sensing ion channel ASIC3 in CGRP peptidergic nociceptors in the dorsal root ganglion (DRG). The activation of CBR signaling suppresses ASIC3-mediated inward currents and subsequent calcium transients, thereby reducing neuronal excitability and ERK phosphorylation in nociceptors. Consequently, targeted activation of CBR or blockade of ASIC3 signaling significantly alleviated postoperative pain hypersensitivity and promoted pain resolution. This study elucidated a novel peripheral mechanism by which CBR-ASIC3 physical and functional coupling in peptidergic nociceptors drives the resolution of incisional pain and provided a theoretical basis for the development of peripherally acting, non-opioid analgesic strategies. - Source: PubMed
Publication date: 2026/09/27
Xu KangtaiJi LuyaoYang HaoyiChen XiyingHu QiaodanHe HaimeiWu JiaweiShan LeyanFeng ShihuiLi YingzhiTan XiongchangWang HaoWang ZilongWu Chaoran - 3D bioprinting is known for its high precision and reproducibility in fabricating complex and customized biomedical constructs. However, its applications are limited by their static nature; i.e., unlike native tissues, they cannot change shape or functionality over time. To overcome this, 4D bioprinting has emerged as a groundbreaking strategy by incorporating time as the fourth dimension, enabling dynamic structures that adapt in response to stimuli, thereby more accurately replicating living tissues. The success of 4D bioprinting hinges on the development of advanced smart bioinks, as their physicochemical properties uniquely dictate the shape-morphing behavior, functionality, and performance of bioprinted constructs. These bioinks must be precisely engineered to respond to specific stimuli. This review first introduces 4D bioprinting technologies for tissue engineering scaffolds. We then outline essential requirements for smart bioinks and highlight how AI, particularly machine learning, is revolutionizing their design. Additionally, we examine widely used biomaterials for 4D bioprinting and discuss promising candidates for 4D printing. We also present cutting-edge bioink applications in tissue engineering, drug screening, and disease modeling, showcasing their potential in regenerative medicine and personalized therapeutics. Finally, we discuss current challenges and future perspectives, underscoring the transformative impact of smart bioinks and 4D bioprinting on biomedical innovation. - Source: PubMed
Publication date: 2026/09/27
Chen ShangsiLai JiahuiZeng QiongjiaoZhou LiangbinYang BoguangZhang BinWang MinZhou JiajingLau KieranLim Khoon SLi Zhong AlanTuan Rocky S - Joint profiling of chromatin accessibility and gene expression in the same cell enables direct linkage of regulatory elements to transcriptional output, but existing approaches remain limited by low co-capture sensitivity, proprietary platforms, and high costs. Here we present DUET-seq, an open-source droplet microfluidic platform for joint profiling of chromatin accessibility and gene expression from the same nucleus. DUET-seq combines programmable dissolvable dual-linker hydrogel beads with one-step intra-droplet RT-PCR to physically co-index RNA and transposed chromatin fragments, completing library preparation within 12 h. Optimization of joint reaction conditions, including suppression of residual Tn5 activity, achieves ∼3,200 genes per HEK293T cell while maintaining high-quality chromatin accessibility profiles. By providing a fully disclosed reagent-and-device ecosystem, DUET-seq enables researchers to optimize lysis and reaction chemistry for non-standard tissues without proprietary constraints. We demonstrate the platform's versatility by mapping over 14,000 cis-regulatory element-to-gene linkages in adult mouse brain and by profiling ∼29,000 nuclei across six stages of postnatal spermatogenesis, where paired measurements reveal two modes of temporal regulatory decoupling-epigenetic priming and chromatin inertia-that are inaccessible to unimodal assays. DUET-seq thus provides an accessible, cost-effective framework for joint single-nucleus multi-omic profiling, with broad applicability across developmental biology, disease epigenomics, and functional genomics. - Source: PubMed
Publication date: 2026/09/27
Cheng DongMeng ZijunWei LanYang PingjingZhang FanfanLuo ZhiyiLai TingLi ChunliZhao MengyaoXu MengqinWang JiaqiLi LinjunChen HuarongLi JinHuang AilongBu YouquanZhao Liuyang