Alkaline phosphatase _ ALPL
- Known as:
- Alkaline phosphatase _ ALPL
- Catalog number:
- BB-PA1004
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Alkaline phosphatase _ ALPL
Related genes to: Alkaline phosphatase _ ALPL
- Gene:
- ALPL NIH gene
- Name:
- alkaline phosphatase, biomineralization associated
- Previous symbol:
- HOPS
- Synonyms:
- TNSALP, TNALP, TNAP
- Chromosome:
- 1p36.12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2018-08-08
Related products to: Alkaline phosphatase _ ALPL
Alkaline Phosphatase Conjugated Affinity Purified anti-Swine IgG (H&L) [Goat] Secondary_Antibodies Alkaline Phosphatase Conjugated Affinity Purified anti_Swine IgG (H&L) [Goat]1-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 900 slides plus (large size1-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 350 plus slides (small size1-step Polymer HISTO-STAT Alkaline Phosphatase multivalant (Secondary Reagent Component) for staining Mouse, Rabbit & Rat primary antibodies, 350 pl1-step Polymer HISTO-STAT Alkaline Phosphatase multivalant (Secondary Reagent Component) for staining Mouse, Rabbit & Rat primary antibodies, 900 plu105 kDa islet cell antigen,BEM-3,Brain-enriched membrane-associated protein tyrosine phosphatase,ICA105,PTP IA-2,PTPLP,Ptprn,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase-like N,R-P12 Lipoxygenase antibody (Alkaline Phosphatase)12 Lipoxygenase antibody (Alkaline Phosphatase)130 kDa myosin-binding subunit of smooth muscle myosin phophatase,Chicken,Gallus gallus,MBS,Myosin phosphatase target subunit 1,Myosin phosphatase-targeting subunit 1,MYPT1,PP1M subunit M110,PPP1R12A,14 kDa phosphohistidine phosphatase,Bos taurus,Bovine,Phosphohistidine phosphatase 1,PHP14,PHPT114 kDa phosphohistidine phosphatase,CGI-202,Homo sapiens,HSPC141,Human,Phosphohistidine phosphatase 1,PHP14,PHPT1,Protein janus-A homolog14 kDa phosphohistidine phosphatase,Mouse,Mus musculus,Phosphohistidine phosphatase 1,Php14,Phpt114 kDa phosphohistidine phosphatase,Oryctolagus cuniculus,Phosphohistidine phosphatase 1,PHP,PHP14,PHPT1,Protein histidine phosphatase,Rabbit14 kDa phosphohistidine phosphatase,Phosphohistidine phosphatase 1,PHP14,PHPT1,Pig,Sus scrofa Related articles to: Alkaline phosphatase _ ALPL
- Biomineralization is essential for skeletal integrity, yet the synergistic roles of tissue non-specific alkaline phosphatase (TNAP) and PHOSPHO1 in postnatal bone remain unclear. We generated a novel murine model with Prx1-driven deletion of Alpl (Alpl) on a global Phospho1 background, circumventing the perinatal lethality associated with dual global deletion and premature death of Alpl global knockouts. Multi-modal spatial phenotyping of the limbs revealed that mice lacking both TNAP and PHOSPHO1 exhibit distinct mineralization defects and altered anatomical structures at postnatal day 1 (PN1) and 3-weeks of age. Although viable, these mice did not thrive due to reduced size; thus further investigations were conducted on mice with heterozygous deletion of TNAP (Alpl;Phospho1). Although smaller than wild-types at PN1 and 3 weeks old, these mice preserved gross limb structure and the single, functioning Alpl allele rescued biomineralization loss following dual phosphatase deletion. In 6-week animals, compromised epiphyses and metaphyses were only observed in Alpl animals. Conversely, diaphyseal geometry and porosity were altered by Phospho1 deletion, compounded in Alpl;Phospho1 mice, and linked to alterations in collagen configuration, matrix mineralization, and growth plate deformities. Together, our findings support a mechanistic framework for TNAP and PHOSPHO1 in permissive biomineralization, providing critical insights into this fundamental process. - Source: PubMed
Publication date: 2026/09/09
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