[Des_Asp187,Met186]_Melanocyte Protein PMEL 17 (185_193) (human, bovine, mouse) Formula C43H69N9O11S Sequence Ile_Met_Gln_Val_Pro_Phe_Ser_Val
- Known as:
- [Des_Asp187,Met186]_Melanocyte Protein PMEL 17 (185_193) (H. sapiens, bovine, mouse) Formula C43H69N9O11S Sequence Ile_Met_Gln_Val_Pro_Phe_Ser_Val
- Catalog number:
- 89920
- Product Quantity:
- 5mg
- Category:
- -
- Supplier:
- GLSChina
- Gene target:
- [Des_Asp187 Met186]_Melanocyte Protein PMEL 17 (185_193) (human bovine mouse) Formula C43H69N9O11S Sequence Ile_Met_Gln_Val_Pro_Phe_Ser_Val
Related genes to: [Des_Asp187,Met186]_Melanocyte Protein PMEL 17 (185_193) (human, bovine, mouse) Formula C43H69N9O11S Sequence Ile_Met_Gln_Val_Pro_Phe_Ser_Val
- Gene:
- PMEL NIH gene
- Name:
- premelanosome protein
- Previous symbol:
- SIL, SILV
- Synonyms:
- D12S53E, SI, Pmel17, gp100
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-24
- Date modifiied:
- 2016-06-10
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- Junken meat sheep display distinct coat-color phenotypes, including a white body with a black head and an entirely black coat at birth, but the transcriptional basis of variation across skin regions and phenotypic backgrounds remains unclear. We performed bulk RNA sequencing (RNA-seq) on nine skin samples from six 1-month-old lambs: black-haired head skin (BT), white-haired dorsal trunk skin (WT), and black-haired dorsal trunk skin from lambs born entirely black (B), with three biological replicates per group. The paired BT-WT comparison characterized within-individual regional differences, whereas B-WT represented a composite phenotypic-background comparison. Cross-comparison integration identified 2056 region-associated genes, 8027 phenotypic-background-associated genes, and 5615 shared genes. Region-associated genes were enriched in mitochondrial and lipid-metabolic processes, phenotypic-background-associated genes in cell communication and adhesion, and shared genes in epidermal keratinization, cytoskeletal organization, and extracellular matrix-integrin-related processes. Network analysis identified a pigmentation-effector subnetwork containing , , , , and . Signature scoring suggested that some contractile signals may reflect tissue-composition differences. Reverse transcription quantitative PCR broadly supported the RNA-seq expression trends. These findings provide a multilayered transcriptional framework for subsequent functional validation of coat-color variation in Junken meat sheep. - Source: PubMed
Publication date: 2026/08/26
Xi BinpengZhao SanchuanYu QianZhang WenzheChen YanWang ZhipengYang HuaLiu Jianbin - The short lifespan of primary normal choroidal melanocytes (NCMs) in vitro represents a major barrier to mechanistic, functional, and translational studies of choroid biology and uveal melanoma (UM). This study aimed to establish and characterize immortalized human NCM lines that retain melanocytic function, maintain a non-cancerous profile, and are amenable to gene editing. - Source: PubMed
Fuentes-Rodriguez AurélieMitchell AndrewGélinas VincentCoutant KellyDroit ArnaudLandreville Solange - Molecular mimicry, where microbial antigens resemble self-antigens, is implicated in triggering autoimmune responses, yet the early B-cell events leading to autoantibody production remain unclear. Here, we generated A5H mice, a knock-in model in which a heavy chain binding to the aquaporin-5 (AQP5) "E" epitope (AQP5E) preferentially generates B cells recognizing a microbial mimic peptide (PmE-L). A5H mice exhibited normal B-cell development with a phenotypic reduction in the anergy-associated B-cell compartment and an expanded pool of mimic-reactive B cells. At steady state, A5H mice produced anti-PmE-L antibodies, whereas anti-AQP5E autoantibodies were not detectable by ELISA. Upon immunization with PmE-L, mimic-reactive B cells were recruited into germinal center responses, leading to robust production of anti-AQP5E autoantibodies that cross-reacted with homologous AQPs (AQP4 and AQP1). Furthermore, A5H mice generated anti-AQP5E autoantibodies upon immunization with streptavidin-complexed PmE-L, indicating that A5H-derived mimic-reactive B cells can overcome competition with the immunodominant carrier antigen streptavidin. However, evidence of intramolecular epitope spreading to native AQP5 was not observed. Consistently, tissue deposition of autoantibodies and salivary gland pathology remained minimal. Notably, autoantibody responses were stronger in heterozygous (+/A5H) than homozygous (A5H/A5H) mice, indicating that allelic inclusion enhances autoreactive B-cell activation. These findings establish A5H mice as a valuable model to dissect how molecular mimicry initiates and diversifies autoreactive B-cell responses, advancing understanding of autoimmune disease initiation. - Source: PubMed
Publication date: 2026/07/02
Kim HyunjinLee NayoonAcharya SabinKim SungminChoi Youngnim - Amyloids are traditionally associated with neurodegenerative and systemic diseases, yet it is now clear that they also perform essential physiological functions across kingdoms of life. Over the last decade, advances in cryogenic electron microscopy (cryo-EM) have enabled high-resolution structural characterization of functional amyloids, transforming our understanding of how the amyloid fold can be repurposed for biological activity. A landmark study in 2020 reported the cryo-EM structure of Orb2, a neuronal amyloid required for long-term memory persistence, establishing the first atomic view of a nuclear amyloid fibril. Subsequent structures of human RNA-binding proteins that form functional amyloids further expanded this paradigm. The structure of hnRNPDL-2 revealed how prion-like low-complexity domains can assemble into highly ordered, stable fibrils while keeping the necessary functionality for RNA metabolism. More recently, cryo-EM structures of the pigment-associated amyloid PMEL have provided insight into the molecular basis of melanosome biogenesis and pigmentation. In parallel, structural studies of bacterial functional amyloids, including the biofilm protein FapC, have uncovered architectures optimized for mechanical robustness and environmental resilience. Together, these pioneering studies reveal shared structural principles, alongside organism-specific adaptations that distinguish functional amyloids from their pathological counterparts. - Source: PubMed
Publication date: 2026/04/02
Ventura SalvadorBartolomé-Nafría AndreaGarcia-Pardo Javier - Junken meat sheep exhibit a characteristic postnatal coat-color transition, in which the initially black fleece gradually fades and develops into a white-trunk phenotype; however, the transcriptional basis of this developmental change in follicular pigment output remains unclear. In this study, three Junken meat sheep lambs showing a natural postnatal black-to-white coat-color transition were sampled longitudinally at the newborn black-fleece stage and the 179-day white-trunk stage, generating three matched biological pairs for RNA-seq analysis. Representative candidate genes were further validated by RT-qPCR. Differential expression analysis identified 1657, 400, and 1086 differentially expressed genes in the C11 vs. C1, C22 vs. C2, and C33 vs. C3 comparisons, respectively. Functional enrichment analysis indicated that these genes were mainly associated with tyrosine metabolism, ECM-receptor interaction, focal adhesion, Phosphoinositide 3-kinase-Akt signaling pathway (PI3K-Akt), arachidonic acid metabolism, estrogen signaling, and immune-related pathways. Integrated analysis of shared downregulated genes and expression patterns highlighted candidate genes related to pigmentation, the ECM/follicular microenvironment, and regulatory or metabolic processes. Pigmentation-related genes, including , , , , and , were generally downregulated in 179-day white-trunk-stage skin, while changes in ECM- and metabolism-related genes suggested altered follicular microenvironmental regulation. These findings identify candidate transcriptional features associated with developmental coat-color fading in Junken meat sheep and support a follicular microenvironment-melanogenesis expression axis as a transcriptome-based framework for further investigation. - Source: PubMed
Publication date: 2026/06/30
Xi BinpengZhao SanchuanYu QianZhou HuaqianZhang WenzheChen YanCheng RuiqiWang ZhipengYang HuaLiu Jianbin