Tubes 13,0 ml PP_RB
- Known as:
- Tubes 13,0 milliliter PP_RB
- Catalog number:
- 252610
- Product Quantity:
- 10
- Category:
- -
- Supplier:
- Herolab
- Gene target:
- Tubes 13 PP_RB
Related genes to: Tubes 13,0 ml PP_RB
- Gene:
- PRB2 NIH gene
- Name:
- proline rich protein BstNI subfamily 2
- Previous symbol:
- -
- Synonyms:
- PRPPRB1, Ps, cP7
- Chromosome:
- 12p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-06-06
Related products to: Tubes 13,0 ml PP_RB
Related articles to: Tubes 13,0 ml PP_RB
- Metastatic progression is the primary cause of death in colorectal cancer (CRC). However, the molecular networks governing CRC metastasis remain incompletely understood, representing a critical knowledge gap. MicroRNAs (miRNAs) are key post-transcriptional regulators frequently dysregulated in CRC, yet their role in metastasis, particularly via non-canonical mechanisms, remains largely underexplored. - Source: PubMed
Publication date: 2026/06/02
Chen SicheLeupold Jörg HPatil Nitin SXu PeirenWang XinyuHu XinyeAllgayer Heike - Inorganic polyphosphate (polyP) is a highly conserved linear polymer of orthophosphate, present across nearly all living organisms. Its functional diversity, particularly through recently discovered post-translational modifications, has garnered increasing scientific interest. However, its role in gene regulation, especially in mammalian systems, remains unexplored. In this study, we present findings that demonstrate that polyP multi-targets the super-enhancer complex to regulate gene expression, marking a novel mechanism of transcriptional control. We show that polyP modifies key components of the complex, including the Mediator subunit MED1, the coactivator Bromodomain-containing protein 4 (BRD4), and the transcriptional regulator Yin Yang 1 (YY1). This polyP-mediated modification not only disrupts their ability to undergo phase separation but also downregulates the expression of MED1 and BRD4, as well as impairs the nuclear localization of YY1. Furthermore, polyP inhibits YY1 dimer formation and disrupts YY1-mediated DNA looping, leading to suppressed gene expression. These discoveries highlight polyP as a novel regulator of super-enhancer-driven gene transcription and provide new insights into the broader role of polyP in epigenetic regulation. This work uncovers a previously unknown layer of gene control, positioning polyP as a critical player in transcriptional regulation through its interaction with transcription factors and coactivators. - Source: PubMed
Yang ZhiyunJia Zongchao - A number of mechanisms that control Yersinia pestis behavior during its complex life cycle in both mammalian hosts and arthropod vectors are known to be thermally regulated. In bacteria, the response to temperature shifts often involves epigenetic factors, particularly changes in DNA methylation. In this study, we aimed to fully characterize the methylome of eleven Y. pestis strains from different subspecies. We described its temperature-dependent features by comparing cultures grown at 22 °C (typical flea environment) and 37 °C (mammalian host temperature). Only two methylation motifs were detected: GATC with 6 mA modifications and CCWGG with 4mC modifications. GATC sites were almost fully methylated across the genome, except regions encoding the Type II secretion system and O‑antigen biosynthesis cluster, and four loci in the pMT1 plasmid. CCWGG sites were reproducibly less methylated at 37 °C than at 22 °C. This cytosine under‑methylation was more pronounced in strains from the ancient 0.PE4 lineage than in the highly pathogenic 0.ANT5 and 2.MED1 strains. Six genes showed reproducible differential methylation in CCWGG sites, including the virulence factor gene yopD and the plasmid gene parA, which is involved in plasmid replication and segregation. Subsequently, we observed a significant increase in the copy number of all Y. pestis plasmids in samples grown at 37 °C compared to those at 22 °C. - Source: PubMed
Publication date: 2026/05/07
D N KonanovA N BalykovaA V VvedenskyA V Lukina-GronskayaO N LiubimovaA V KovrizhnikovA S SperanskayaD V KrivonosG A EroshenkoE N IlinaV M GovorunV V Kutyrev - Multiple epiphyseal dysplasia (MED) is a clinically and genetically heterogeneous group of disorders characterized by a waddling gait, joint pain, and early-onset osteoarthritis. The aim of this study was to compare the genetic characteristics and long-term clinical follow-up findings of 22 patients with MED from 17 unrelated families. Molecular diagnosis was performed using clinical exome analysis and exome sequencing. Seventeen children were followed for a median of 5.5 years. Eighteen disease-related variants were identified: 47% in , 11.8% each in and in a monoallelic state, 17.6% in , and 11.8% each in and in a biallelic state. Some mutations previously identified in pseudoachondroplasia, an allelic disorder of MED1, were shown in our study to exhibit a typical MED1 or intermediate phenotype. In contrast, it was confirmed that certain mutations in lead to MED4 phenotype. Furthermore, it has been observed that biallelic variants in may be associated with the MED5 phenotype. In patients with MED2 and MED3, the knee joint is affected, while in other types, the hip joint is predominantly affected. In 15 children followed until ages 11-18, height decreased slightly as they grew older but remained normal or at the lower limit, and slow progression was observed in the waddling gait and joint pain, except in the intermediate form. This study reveals the frequency of disease-related variants, including seven novel ones, in genes leading to MED1-5 and 7 phenotypes, and expands the spectrum of genetic and clinical phenotypes. - Source: PubMed
Publication date: 2026/04/15
Taner Hasan EmirUludağ Alkaya DilekKalyoncu Uçar AyşeŞeker AliCentel TuncayYıldırım TimurGüneş NilayTüysüz Beyhan - The mechanisms by which core clock components are spatially organized to ensure robust oscillations in mammals remain unclear. Here, we identify the positive limb factor BMAL1 as a phase-separating protein that forms dynamic biomolecular condensates essential for circadian transcription and behavior. Endogenous BMAL1 forms nuclear puncta that oscillate in sync with the circadian cycle. Deletion analysis and optogenetic clustering identify an N-terminal 90-amino acid intrinsically disordered region whose phosphorylation state tunes BMAL1 phase separation. Besides, BMAL1 condensates behave as multi-molecular assemblies that selectively recruit CLOCK, p300, MED1, and are specifically promoted by E-box DNA. Functionally, an IDR-deleted BMAL1 mutant fails to rescue rhythmic transcription in Bmal1-KO cells and cannot restore locomotor rhythms when reintroduced into SCN-specific Bmal1‑KO mice. These findings establish BMAL1 condensates as dynamic transcriptional hubs that couple phase separation to circadian rhythm in cells and in vivo. - Source: PubMed
Publication date: 2026/05/01
Gao WenzhenZhu LiWei YaliLuo GuowenWang JiaheWang LijiePeng ZhengyingLi XuanWu ZhuoxuanLi JingyiWu YanfenWang XiaoxiaoJing JunjunZou ShujuanZhao QingFan YiYuan QuanZhou Chenchen