Histone H3 Polyclonal, Rabbit Chromosomal surfaces are ornamented with a variety of posttranslational modifications of histones, which are required for the regulation of many of the DNA_templated proc
- Known as:
- Histone H3 Polyclonal, Rabbit Chromosomal surfaces ornamented a variety posttranslational modifications histones, required regulation on DNA_templated proc
- Catalog number:
- AB-004-100
- Product Quantity:
- 100 ul
- Category:
- -
- Supplier:
- BBridge
- Gene target:
- Histone H3 Polyclonal Rabbit Chromosomal surfaces are ornamented with variety posttranslational modifications histones which required for the regulation many DNA_templated proc
Related genes to: Histone H3 Polyclonal, Rabbit Chromosomal surfaces are ornamented with a variety of posttranslational modifications of histones, which are required for the regulation of many of the DNA_templated proc
- Gene:
- PROC NIH gene
- Name:
- protein C, inactivator of coagulation factors Va and VIIIa
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: Histone H3 Polyclonal, Rabbit Chromosomal surfaces are ornamented with a variety of posttranslational modifications of histones, which are required for the regulation of many of the DNA_templated proc
guanine nucleotide binding protein alpha inhibiting activity polypeptide 1 (GNAI1) polyclonal antibody kinase suppressor of ras (KSR) polyclonal antibody"Affordable Gel Doc System with UV, Epi white & white
backlight Source for fluorescencent dye-stained DNA (ex.
EtBr)/protein (ex. SYPRO Ruby) gel imaging"(+) Control probe (DNA), biotinylated(-) Control probe (DNA), biotinylated(Alpha)_ 1 _ antitrypsin (A1AT) POLYCLONAL Rabbit anti_human(Alpha)_ Feto Protein (AFP) POLYCLONAL Rabbit anti_human(Alpha)_ Feto Protein (AFP) POLYCLONAL Rabbit anti_human(Alpha)_1_ antitrypsin (A1AT) POLYCLONAL Rabbit anti_human(Arg6,b_cyclohexyl_Ala8,D_Tic16,Arg17,Cys18)_Atrial Natriuretic Factor (6_18) amide (mouse, rabbit, rat) Salt _ Binding (Disulfide_bond) Synonym A71915 SumFormula C69H116N26O15S2(Arg6,b_cyclohexyl_Ala8,D_Tic16,Arg17,Cys18)_Atrial Natriuretic Factor (6_18) amide (mouse, rabbit, rat) Salt _ Binding (Disulfide_bond) Synonym A71915 SumFormula C69H116N26O15S2(Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat)
A71915 98% C69H116N26O15S2 CAS:(Arg8)-Vasopressin - Diluted Antiserum for RIA, Host Rabbit(Arg8)-Vasopressin - Diluted Antiserum for RIA, Host: Rabbit(Arg8)-Vasopressin - Diluted Antiserum for RIA, Host: Rabbit Related articles to: Histone H3 Polyclonal, Rabbit Chromosomal surfaces are ornamented with a variety of posttranslational modifications of histones, which are required for the regulation of many of the DNA_templated proc
- Governments across the globe are turning to place-based industrial policies to make the green transition more equitable and politically palatable. The United States' Inflation Reduction Act exemplifies this approach through its "Energy Community" provisions, which offer additional tax incentives for clean energy projects in regions reliant on fossil fuels. We use spatially granular data on renewable energy investment, employment, and voting, and document that these incentives substantially increased local solar investment, but we do not find significant impacts on wind investment, job creation, or political preferences. Estimated abatement costs are well below the social cost of carbon and lower than those of other major U.S. climate policies. The results suggest that place-based green industrial policies can effectively direct clean energy investment toward disadvantaged regions, but their capacity to generate broader local economic or political benefits may be limited. - Source: PubMed
Publication date: 2026/08/14
Keuzenkamp JoepMazza JacopoRijkers BobStapleton Katherine - Messenger RNA (mRNA) therapeutics hold potential for central nervous system (CNS) disease treatment. However, the blood-brain barrier (BBB) presents a major obstacle, preventing efficient delivery of mRNA into the brain. To overcome this challenge, we designed, synthesized, and tested a series of ionizable lipids and formulated them into CNS-accessing lipid nanoparticles (CA LNPs) to deliver mRNA. The lead candidate among them, CA2d LNP, demonstrated efficient mRNA delivery across the BBB following intravenous injection. In wild-type mice, Ai14 mice, and nonhuman primates, CA2d LNPs effectively delivered various mRNA cargos into multiple key CNS cells, including neurons, microglia, and astrocytes, across different brain regions. In an ischemic stroke rat model, CA2d LNPs codelivering thrombolytic agent and neuroprotective mRNAs reduced infarct volume and improved neurological function. Collectively, this CNS-accessing LNP platform provides a promising strategy for overcoming the BBB and enabling effective mRNA-based therapies for a broad range of CNS disorders. - Source: PubMed
Publication date: 2026/08/14
Wang SiyuZhong YichenWang ChangTian MengBennett Jeffrey LBliss-Moreau ElizaXue YongerYu ChangyueHou XuchengZheng Ya YingLi HaoyuanLiu ZhengweiCao DinglinggeKang Diana DDeng BinbinDong Yizhou - With 21 outer-membrane transporters dedicated to iron acquisition, possesses an extensive toolkit for securing this essential nutrient, but activates the expression only of those relevant to its immediate environment. Eighteen of these pathways rely on siderophores, two produced by and the others acquired from neighboring microorganisms through a siderophore-piracy strategy. Using fluorescent reporters and mathematical modeling, we quantified how catechol-type siderophores regulate transcription of their matched transporters, PfeA, FvbA, PirA, and PiuA. and showed switch-like induction by enterobactin and vibriobactin, starting at around 100 nM and plateauing at 1 µM. In contrast, -(2,3-dihydroxybenzoyl)-L-serine, an enterobactin degradation product, selectively induced transcription only in strains lacking endogenous siderophores, via a gradual response spanning 250 nM to 100 µM. transcription was strongly induced by host catecholamines, with activation thresholds of 1 µM for epinephrine, 5 µM for norepinephrine, and 10 µM for L-DOPA, and plateaus between 30 and 150 µM. Iron repression uncovered distinct regulatory regimes: , and display biphasic Fur-dependent repression, with transcription decreasing beginning at 4 to 16 nM Fe and fully repressed by 32 µM, whereas transcription began to decrease at 8 µM iron and was not fully repressed even at 2 mM. Together, these results reveal distinct transcriptional logics that allow to sense and decode a wide array of environmental catechols, integrate this information with iron availability, and thereby deploy an iron-uptake strategy finely tuned to competitive and host-associated niches. - Source: PubMed
Publication date: 2026/08/14
Volck FlorianRevillot-Schmidt Anne-EloïseHubert ThibautCrespin VictorMislin Gaëtan L ACunrath OlivierMadec MorganSchalk Isabelle J - Earth's organic chemical evolution (OCE) from abiotic to prebiotic to biotic provides critical insights that may have implications for how we interpret observations made by life-detection planetary missions. To search for life on other worlds, astrobiologists seek biosignatures: features that indicate the presence of extant or extinct life as we know it. However, because the age of putative extraterrestrial biospheres is unknown, biosignatures present at or shortly after life's emergence may have been diluted with prebiotic or abiotic signatures. Thus, the emergence of biosignatures and their formation context are critical considerations for mission interpretations, especially where there is no obvious pervasive biosphere. Here, we provide a structured approach for interpreting chemical states across the continuum of OCE on a planetary body. We distinguish between universal biosignatures of a world vs. specific biosignatures that are tied to environmental or temporal conditions of that world. We then consider how the evolution of a planetary body would impact the expression of these signatures over time. The detection of active prebiotic chemistry-that is, signatures that fall in the ambiguous transition between prebiotic and living systems-would be a hallmark discovery, providing insight into life's origins and justifying investment in further exploration of such worlds. Leveraging Earth as an example, we suggest that while mission observations may be more challenging to interpret than previously thought, they may also open doors to a more productive exploration of our planetary neighbors. - Source: PubMed
Publication date: 2026/08/14
Barge Laura MEigenbrode Jennifer LFournier GregoryTheiling Bethany - Human aquaporins are integral membrane proteins that facilitate transmembrane transport of small molecules. Among the 13 members of this family, pH-regulated human aquaporin-10 (hAQP10) plays a critical role in glycerol metabolism and lipid homeostasis. A molecular-level understanding of water and glycerol transport through hAQP10 nanopores is essential for enabling rational therapeutic interventions. We present an all-atom molecular dynamics (MD) simulation study characterizing the nanoscale structure, thermodynamic stability, and glycerol permeability of tetrameric hAQP10 channels embedded in lipid bilayer membranes. Using equilibrium and advanced sampling MD simulations, we investigate the cooperative diffusion of water and glycerol through the channel. Free energy (ΔG) landscape derived from replica-exchange umbrella sampling simulations reveals multiple binding sites and energy barriers of a few kT along the channel axis. Integrating the (ΔG) profile with the inhomogeneous solubility-diffusion model, we estimate a single channel diffusive permeability of glycerol through hAQP10 to be 4 × 10 cm/s at a concentration of 100 mM. Glycerol residence times in the channel during unbiased simulations range from nanoseconds to microseconds. Transport kinetics, characterized using a theoretical model derived by coarse-graining all-atom simulation trajectories, indicate a mean first-passage time of several microseconds. Steered molecular dynamics simulations comparing water and glycerol permeation energetics reveal similar barriers in the open conformation. Together, these findings provide a comprehensive quantitative picture of glycerol and water permeation through hAQP10, with potential implications in understanding physiological role of hAQP10 in human health. - Source: PubMed
Publication date: 2026/08/14
Rai KunalJoshi Himanshu