SLC12A2
- Known as:
- SLC12A2
- Catalog number:
- ARP43805_T100
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- SLC12A2
Related genes to: SLC12A2
- Gene:
- SLC12A2 NIH gene
- Name:
- solute carrier family 12 member 2
- Previous symbol:
- -
- Synonyms:
- NKCC1, BSC, BSC2, PPP1R141
- Chromosome:
- 5q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-02-16
- Date modifiied:
- 2016-02-17
Related products to: SLC12A2
Anti- SLC12A2 (solute carrier family 12 (sodium potassium chloride transporters). member 2) Antibodyanti-SLC12A2 NKCC1 (5H7)anti-SLC12A2 NKCC1 (5H7) type: Primary antibodies host: MouseAnti-SLC12A2 (5H7), Mouse Monoclonal to SLC12A2, Isotype IgG2b, Host Mouseanti-SLC12A2 / NKCC1anti-SLC12A2 / NKCC1anti-SLC12A2 / NKCC1anti-SLC12A2 / NKCC1anti-SLC12A2 / NKCC1 (5H7)anti-SLC12A2 / NKCC1 (Internal)Anti-SLC12A2, Goat Polyclonal to SLC12A2, Isotype , Host GoatAntibodies: SLC12A2 HOST: Goat Clonality: pAbBasolateral Na-K-Cl symporter,Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1,Homo sapiens,Human,NKCC1,SLC12A2,Solute carrier family 12 member 2Basolateral Na-K-Cl symporter,Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1,Mouse,Mus musculus,Nkcc1,Slc12a2,Solute carrier family 12 member 2By moving chloride into epithelial cells, the Na-K-Cl cotransporter SLC12A2 aids transcellular movement of chloride across both secretory and absorptive epithelia.By moving chloride into epithelial ce Related articles to: SLC12A2
- Early postnatal development is a sensitive period for inhibitory maturation, during which GABAergic signaling shifts from depolarizing to hyperpolarizing as a function of the chloride cotransporters KCC2 and NKCC1. Although these cotransporters are key to inhibitory development, little is known about how early caregiving influences their maturation in cortical circuits supporting attachment learning. We characterized KCC2 and NKCC1 expression in the piriform cortex (PC) of male and female rats from postnatal (P) Day 5 to 22 and assessed their sensitivity to altered caregiving using the limited bedding and nesting (LBN) paradigm (P2-P9). Both cotransporters showed robust postnatal protein upregulation, with sex-specific transcriptional differences for KCC2. At P15, LBN induced sex- and region-dependent changes. KCC2 transcription decreased in the anterior PC of males but increased in females in the posterior PC. NKCC1 protein was reduced in both sexes with distinct anterior-posterior patterns. Using a single-neuron Hodgkin-Huxley model with dynamic ion concentrations incorporating the measured cotransporter profiles, simulations indicated that these differences were sufficient to modify chloride homeostasis and shift GABAergic control of excitability. This multiscale approach links early alterations in caregiving to predicted functional consequences for inhibitory maturation in the PC. - Source: PubMed
Becerra-Flores ChristellOruro Enver MMedina-Saldivar CarlosPacheco-Otálora Luis FPardo Grace E - Lymphedema is a chronic condition characterized by the accumulation of fluid due to impaired lymphatic drainage, frequently occurring secondary to chronic venous insufficiency (CVI), malignancy, or obesity. Despite known environmental and clinical risk factors, the genetic contributors to lymphedema and CVI have been understudied. - Source: PubMed
Publication date: 2026/04/22
Peloso Gina MAdhikari NimishYoung Melissa MCho KellyKinlay Scott - Colorectal cancer (CRC) remains a leading cause of cancer‑related morbidity and mortality worldwide. Although the adenoma-carcinoma sequence and its genetic drivers are well described, the earliest cellular and molecular events initiating tumorigenesis within histologically normal colonic epithelium remain poorly defined. This study aims to identify tumor‑initiating cells (TICs), distinguish them from normal stem‑like cells (nSTMs), and delineate early transcriptional and signaling programs using single‑cell RNA sequencing (scRNA‑seq) from paired normal‑appearing and transformed human colonic tissues. - Source: PubMed
Publication date: 2026/03/27
Jaiswal SangeetaThe StephanieChang Tse-ShaoShi JiaqiWang Thomas D - Colorectal cancer (CRC) is the thirdmost common cancer and a leading cause of cancer deaths worldwide, with over 1.9 million cases diagnosed in 2022. Due to poor response to classical cancer treatments, CRC is associated with low survival rates. This creates an urgent need for better understanding of CRC pathology. Cell death occurs continuously in solid tumors, and is also induced acutely, during chemotherapy. Dead cells are cleared by phagocytes via 'efferocytosis', an anti-inflammatory process that can lead to immune escape and reduced therapeutic efficacy. We hypothesized that efferocytosis might contribute to tumor development and that manipulating this process could be beneficial for CRC therapy. - Source: PubMed
Publication date: 2026/03/09
Boeckaerts LauraAaes Tania LøveScheirlinckx EviChoi Sze MenIncik YunusGonçalves AmandaHochepied TinoVereecke LarsRavichandran Kodi S - Stress promotes the progression from borderline hypertension to sustained hypertension, but the mechanism remains unclear. We investigated the role of corticotropin-releasing factor (CRF)-expressing neurons in the central nucleus of amygdala (CeA) on arterial blood pressure (ABP) and sympathetic activity of borderline hypertensive rats (BHRs) subjected to chronic unpredictable mild stress (CUMS). CUMS induced sustained hypertension, and led to increased delta-FosB expression as well as enhanced spontaneous and evoked firing of CeA CRF-expressing neurons in BHRs. Furthermore, optogenetic activation of CeA CRF-expressing neurons significantly increased the sympathetic outflow and ABP in BHRs. Impaired GABAergic inhibition, a depolarizing shift of GABA reversal potential (EGABA), disrupted chloride homeostasis and increased NKCC1 expression were observed in CeA CRF-expressing neurons in BHRs subjected to CUMS. NKCC1 inhibition with bumetanide restored GABAergic inhibition and chloride homeostasis, normalized neuronal excitability, leading to reduced sympathetic vasomotor tone in CUMS BHRs. These results indicate that NKCC1-mediated disruption of chloride homeostasis in CeA CRF-expressing neurons contributes to elevated sympathetic activity and hypertension under chronic stress. These findings enhance our understanding of the neuronal and molecular mechanisms underlying stress-induced hypertension and reveal potential targets for its prevention and treatment. - Source: PubMed
Publication date: 2026/03/16
Ma HongyuZhang YingGuo XinqiZhao QiyueYang PeiyunLiu YanGuan YueWei YanMa Huijie