Anti_Mouse, mab TNFSF8 Source Rat
- Known as:
- Anti_Mouse, mab TNFSF8 Source Rat
- Catalog number:
- 103-M496
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Reliatech
- Gene target:
- Anti_Mouse mab TNFSF8 Source Rat
Related genes to: Anti_Mouse, mab TNFSF8 Source Rat
- Gene:
- TNFSF8 NIH gene
- Name:
- TNF superfamily member 8
- Previous symbol:
- CD30LG
- Synonyms:
- CD153
- Chromosome:
- 9q32-q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-08
- Date modifiied:
- 2018-02-13
Related products to: Anti_Mouse, mab TNFSF8 Source Rat
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- Multiple sclerosis (MS) is a complex immune-mediated disorder with polygenic and multicellular underpinnings, necessitating cell-type-specific molecular studies to delineate dysregulated pathways. Here, we profile 1,075 transcriptomes from 167 patients with MS and 42 healthy participants across six peripheral immune cell-type-states. MS-associated transcriptional differences are more pronounced in primary (unstimulated) immune cells than in in vitro-stimulated counterparts. We identify shared and cell-type-specific transcriptional alterations at the level of genes, pathways, and co-expressed gene modules, prioritizing regulators, such as ZBTB16, across T cells and monocytes, and replicating six MS-associated modules in independent datasets. The top T cell module is enriched for MS susceptibility genes and affects proliferation. The top monocyte module implicates dysregulated TNF-α/NF-κB signaling, for which an in silico drug screen and in vitro validation nominate alvespimycin as a candidate modulator. Together, these findings define stable peripheral immune dysregulation signatures in MS that may serve as diagnostic or prognostic biomarkers in at-risk individuals. - Source: PubMed
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