Human GM_CSF Source Insect cells
- Known as:
- Human GM_CSF Source Insect cells
- Catalog number:
- 400-011-DC
- Product Quantity:
- 50 µg
- Category:
- -
- Supplier:
- Reliatech
- Gene target:
- Human GM_CSF Source Insect cells
Related genes to: Human GM_CSF Source Insect cells
- Gene:
- CSF2 NIH gene
- Name:
- colony stimulating factor 2
- Previous symbol:
- -
- Synonyms:
- GM-CSF, GMCSF
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2018-12-12
Related products to: Human GM_CSF Source Insect cells
Related articles to: Human GM_CSF Source Insect cells
- Depletion of CD4 cells during an anti-tumor immune response promotes tumor regression and accelerates proliferation of tumor-antigen-specific CD8 T cells in draining lymph nodes (dLNs). However, the effect of the depletion on inter-organ kinetics of antigen presentation and qualitative changes in dendritic cells (DCs) are not yet understood. Here, we established a novel approach for simultaneous detection of cellular movement and cell cycle phase by KikGR/Fucci mice and used it to examine migratory and LN resident DC (LNDC) dynamics after CD4 cell depletion. We found that CD4 cell depletion enhanced migration of CD11c MHC class II migratory DCs from tumor to dLNs and induced activation-associated phenotypic changes, such as increased MHC class II expression. Despite reduced overall cellularity in tumor dLNs, LNDC numbers were relatively maintained. Within the LNDC compartment, CD4 depletion increased the relative abundance of a CD8αCD11b subset and promoted influx and cell-cycle activity among newly recruited LNDCs. Publicly available single-cell RNA sequencing data further delineated ligand-receptor expression relationships, including and axes, within tumor dLNs. These findings reveal remodeling of DC migration, activation, and LNDC turnover within tumor dLNs in the context of CD4 cell depletion, which enhanced anti-tumor immunity. - Source: PubMed
Publication date: 2026/06/10
Moriya TaikiHashimoto MayukoUeda MizukiAoyagi TatsuyaKawaguchi AyakoTakahashi KentaroTsukasa KobayashiDoi KazukiHemmi HiroakiKaisho TsuneyasuUeha SatoshiMatsushima KojiKusumoto YutakaChtanova TatyanaTomura Michio - Radiation-induced lung injury (RILI) represents a severe, therapy-refractory complication of thoracic radiotherapy. Although neutrophils have been implicated in RILI pathogenesis, the specific pathogenic subsets and the molecular mechanisms governing their recruitment and functional specialization remain elusive. This study aims to decode the crosstalk between damaged epithelial cells and neutrophils in the RILI microenvironment. - Source: PubMed
Publication date: 2026/06/10
Wang YunAbulaihaiti MaidinaPan YanZhang JianghongShao Chunlin - To investigate the role of non-HLA antibodies in kidney allograft rejection, we developed a non-HLA antibody Luminex assay to identify kidney transplant recipients at risk of allograft rejection. Protein microarray analysis (>1.5 fold; p<0.05) of 16 rejection positive, endothelial cell crossmatch positive patients identified 135 non-HLA antigens. From these, 12 novel antigens were prioritized for their membrane localization, kidney expression, and identification in more than one patient. A Luminex assay including these 12 novel antigens with 67 previously reported non-HLA antigens was developed and validated in two independent kidney transplant cohorts: an adult kidney (n=160) and a longitudinal pediatric kidney (n=62). Relative risk ratio analysis identified 3 non-HLA antibodies associated with rejection in the adult cohort (p<0.05) and 15 associated with rejection in the pediatric cohort (p<0.1), including 8 with strong significance (p<0.05). A correlation matrix identified 4 non-HLA antibodies independently associated with rejection (PLA2R1, CSF2, GSTT1, LGALS8). Decision tree analysis predicted rejection 71% of the time. 4/12 novel antigens were corroborated in the validation cohorts. CSF2 was associated with acute peritubular capillaritis (ptc) and acute intimal arteritis (p<0.05). These findings suggest that non-HLA antibodies are associated with an increased risk of rejection in kidney transplant recipients. - Source: PubMed
Publication date: 2026/06/09
Butler Carrie LHickey Michelle JPearl Meghan HZheng YingGjertson DavidSunga GemaleneChen LuciaVangala SitaramElashoff DavidWeng PatriciaLum ErikBunnapradist SuphamaiAbdalla BasmahPham Phuong-ThuYabu Julie MSethi SupreetKendrick ElizabethDanovitch GabrielNassiri NimaVeale JeffreyGritsch Hans ABratton TiffanyRay BryanReed Elaine F - The global rollout of 5G networks has raised questions regarding the potential biological effects of millimeter-wave exposure, particularly in the skin due to its limited penetration depth. This study examined the effects of whole-body exposure to 27.5 GHz millimeter waves, a frequency within the 5G FR2 bands, on skin-related biological responses in early life mice. Patched1- heterozygous knockout and wild-type CD1 mice were exposed from birth to weaning (P21), 23 h per day, in 10-minute ON/5-minute OFF cycles, at two power densities (6.67 and 20 W/m²). SHAM-exposed animals served as a control. No overt histological abnormalities were observed in exposed skin. However, molecular analyses revealed significant modulation of inflammation-related gene expression. Notably, Ccl4, Csf2, and Tnfsf11 emerged as central regulatory nodes, displaying high degree and betweenness centrality across all groups, irrespective of genotype and sex. Crucially, exposure significantly stimulated mast cell degranulation and, in wild-type mice, led to a reduction in cutaneous glutamate levels. Concurrently, a down-regulation of transcripts associated with cutaneous sensory components (Calca, Mrgprd) was observed within the skin microenvironment. These findings show that 27.5 GHz exposure induces coordinated changes in cutaneous inflammatory pathways and mast cell-mediated homeostasis without detectable structural damage. Overall, these results demonstrate a localized molecular and cellular response within the cutaneous microenvironment, reflecting a subtle homeostatic shift, and suggest that genetic background may contribute to variability in the biological response to millimeter-wave exposure. - Source: PubMed
Publication date: 2026/06/08
Palone FrancescaFratini EmilianoNovelli FlaviaLeonardi SimonaDe Stefano IlariaPasquali EmanuelaTanori MirellaPinto RosannaArdoino LuciaZambotti AlessandroCamera FrancescaPiscitelli MartaMerla CaterinaPazzaglia SimonettaCapstick MylesSamaras TheodorosMancuso Mariateresa - Photodynamic therapy (PDT) is a promising treatment for cholangiocarcinoma (CCA), but its efficacy is limited by robust tumor antioxidant defenses and immunosuppressive microenvironment. Disrupting the expression of SLC6A6, a taurine transporter critical for redox homeostasis, represents a promising strategy for sensitizing CCA cells to PDT by disrupting taurine-mediated antioxidant protection. - Source: PubMed
Publication date: 2026/06/02
Zhu JingjinZou TianhaoWang WeiminXu JianjunLi XuanLiu LeiYang BohanSong ZifangGao Yang