ZIC4
- Known as:
- ZIC4
- Catalog number:
- ARP39680_P050
- Product Quantity:
- 50 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- ZIC4
Related genes to: ZIC4
- Gene:
- ZIC4 NIH gene
- Name:
- Zic family member 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-03
- Date modifiied:
- 2013-01-08
Related products to: ZIC4
Related articles to: ZIC4
- Paraneoplastic Neurological Syndromes (PNSs) comprise a rare group of disorders present in various types of malignant neoplasia. In most cases, PNSs precede the clinical symptoms and diagnosis of a tumor by years. It is therefore vital to recognize these neurological disorders, as early diagnosis of the neoplasia offers the opportunity for timely initiation of treatment and may improve patient outcomes. - Source: PubMed
Publication date: 2026/07/23
Hristozov MilenShukerski KrasimirYaneva AntoniyaMurdjeva Marianna - Down feathers and contour feathers are two distinct feather types with vastly different structures and functions coexisting in the same individual. However, the molecular mechanism underlying these differences remains unclear. In this study, skin tissue containing intact feather follicles was collected from four anatomically defined regions of healthy Beijing ducks () for transcriptomic sequencing: the breast and abdomen, which generate down feathers, and the wingtips and rump, which produce contour feathers. To mitigate bias arising from site-specific effects, we established paired comparisons between contour feathers and down feathers across different regions. Across all comparisons, 36 core differentially expressed genes (DEGs) were consistently identified. These encompassed nine family transcription factors across three paralogous clusters, family members ( and ), , , , cytoskeletal and sarcomeric genes (, , , ), extracellular matrix regulators (, , ), and lipid metabolism-related genes (, ), among others. Pathway enrichment analysis revealed that transcriptomic variations in different feather follicles involve gene modules functioning in positional identity, cytoskeletal organization, extracellular matrix remodeling and lipid metabolism, with potential neuroendocrine modulation. The transcriptomic dataset established here facilitates future studies on the molecular mechanisms of feather differentiation and offers a reference for molecular breeding to enhance down feather yield and quality of Beijing ducks. - Source: PubMed
Publication date: 2026/07/22
Wang WenguiGuo JiangpengWang LiangZhang MengZhang XinyeJiang XiaoyuChen TairanMei XiaohanRen XufangQu Lujiang - Paraneoplastic neurological syndromes (PNS) associated with triple-negative breast carcinoma (TNBC) are exceptionally rare. We report a case of fulminant encephalitis in a middle-aged woman with TNBC presenting with concurrent PNMA2 (Ma2/Ta), ZIC4 and recoverin antibody positivity. The patient initially developed a subacute cerebellar syndrome characterised by downbeat nystagmus, gait ataxia and diplopia. Comprehensive evaluation revealed FDG-avid left axillary lymphadenopathy and biopsy confirmed high-grade TNBC with PD-L1 CPS of 77. She received neoadjuvant chemo-immunotherapy as per standard institutional protocol (paclitaxel, carboplatin, epirubicin, cyclophosphamide and pembrolizumab). Following the sixth cycle, she developed refractory focal seizures progressing to status epilepticus with MRI findings consistent with cortical encephalitis. Despite aggressive immunosuppression including corticosteroids, intravenous immunoglobulin and rituximab, her condition proved refractory. She ultimately succumbed despite maximal supportive care. This case illustrates a rare paraneoplastic overlap syndrome combining PNMA2-associated encephalitis and ZIC4-associated cerebellar degeneration in TNBC, highlights diagnostic challenges when immune checkpoint inhibitors may amplify pre-existing onconeural immunity and underscores the dismal prognosis of intracellular antibody-mediated neurological syndromes despite aggressive immunotherapy. - Source: PubMed
Publication date: 2026/07/13
Gautam Roy PrabhatJagtap Aniket BGogia Ajay - - Source: PubMed
Publication date: 2025/12/29
Çiçek SultanYıldırım MiraçBektaş ÖmerTeber Serap - Dandy-Walker malformation (DWM) is a condition characterized by a cyst in the posterior cranial fossa contiguous with the fourth ventricle, combined with complete or partial agenesis of the cerebellar vermis; and elevation of the cerebellar tentorium, torcular Herophili, and transverse sinuses. DWM has been linked to specific genetic variants, with pathogenic or likely pathogenic variants reported in FOXC1, ZIC1, and ZIC4. Variants in the TUBB2B and TUBB3 genes are associated with abnormalities in tubulin, leading to cerebellar hypoplasia. In our study, three patients diagnosed with DWM underwent whole-genome analysis using next-generation sequencing, and two were found to have heterozygous variants in the tubulinopathy-associated genes TUBB2B and TUBB3, respectively. These findings indicate that some cases previously diagnosed as DWM may fall under the spectrum of tubulinopathies associated with cerebellar hypoplasia. - Source: PubMed
Publication date: 2026/06/17
Ueno KatsuyaHigasa KoichiroHayashi MikioIsozaki HarunaMiyata MayukoNaito NobuakiLi YiTakeda JunichiNonaka Masahiro