Anti_Human, mab CXCR5 Source Mouse
- Known as:
- Anti_Human, mab CXCR5 Source Mouse
- Catalog number:
- 101-M364
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Reliatech
- Gene target:
- Anti_Human mab CXCR5 Source Mouse
Related genes to: Anti_Human, mab CXCR5 Source Mouse
- Gene:
- CXCR5 NIH gene
- Name:
- C-X-C motif chemokine receptor 5
- Previous symbol:
- BLR1
- Synonyms:
- MDR15, CD185
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-29
- Date modifiied:
- 2016-03-14
Related products to: Anti_Human, mab CXCR5 Source Mouse
Related articles to: Anti_Human, mab CXCR5 Source Mouse
- Multiple sclerosis (MS) is a heterogeneous autoimmune disorder of the central nervous system of polygenic nature. Uncovering the genetic predictors of MS phenotype can help to explain the nature of the disease's clinical heterogeneity, and contribute to the development of novel tools for precise disease prognosis. We conducted a retrospective genetic association study of 35 polymorphic variants in immune-related genes with MS severity assessed using the Multiple Sclerosis Severity Score (MSSS) in a sample of 548 Russian relapsing-onset MS patients who have not previously received immunomodulatory therapy. Variants in the , , , , , , , , , and genes were identified as MSSS-associated in at least two of the three models analyzed (MSSS > 3.5 versus ≤3.5; MSSS > 5.0 versus <2.5; MSSS as a continuous variable). Among them, variants in , and genes were associated with MSSS only in women, while variants in the and genes only in men. The variant in was MSSS-associated both in the total sample and in subgroups of female and male MS patients. Thus, we demonstrate that several GWAS-identified MS risk genes, along with other immunological loci, act as modifiers of the MS phenotype. - Source: PubMed
Publication date: 2026/06/13
Kulakova OlgaBaulina NataliaKozin MaximMatveeva NataliaBoyko AlexeyFavorova OlgaKiselev Ivan - To investigate the mechanism of electroacupuncture (EA) for attenuating visceral hypersensitivity in rats with post-inflammatory irritable bowel syndrome (PI-IBS) using transcriptome sequencing technology. - Source: PubMed
Publication date: 2025/06/04
Chang XiaoliWang LijunZhang LiliYang ZongbaoChen Shaozong - T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells play critical roles in regulating the activity of the germinal center (GC), which is essential for the generation of high-affinity antibodies. In the GC, Tfh cells help B cells to proliferate and to differentiate into memory B cells and long-lived plasma cells. In contrast, Tfr cells, a specialized subset of regulatory T cells (Tregs), modulate the humoral immune response by suppressing excessive or autoreactive B-cell activity. Here, we established an in vitro differentiation protocol for mouse CD4⁺ T cells that yielded CXCR5⁺FoxP3⁺ Tfr cells that exhibited a Bcl6PD-1CD25GITR phenotype and were distinct from Treg and Tfh cells. Functionally, in vitro-generated Tfr cells potently suppressed Tfh cell-driven B-cell class switching to IgG1 and downregulated the expression of B-cell costimulatory ligands. While in vitro-generated Bcl6-deficient Tfh cells were impaired in providing help to B cells for efficient class switching to IgG1, in vitro-generated Bcl6-deficient Tfr cells failed to inhibit Tfh cell-driven B-cell class switching to IgG1. Mechanistically, we showed that Tfr cells emerged from FoxP3 precursors in low-IL-2 environments through a TGF-β- and c-Maf-dependent pathway, allowing for reprogramming and reinforcement of the follicular regulatory cell program in CD4 T cells in vitro. - Source: PubMed
Publication date: 2026/06/25
Bach LuisaChang YinshuiArteaga Transito OlinGhasemi MohammadaminSteinheuer Lisa MariaSteffen TeresaDe Domenico ElenaUlas ThomasWunderlich F ThomasBeyer Marc DThurley KevinBaumjohann Dirk - Dermatofibromas (DFs) are common, benign firm dermal nodules. It is well known that their onsets often follow minor injuries, including insect bites or arthropod assaults on-site. The frequency of DF cases associated with lymphoid follicles (LF) harboring germinal center (GC) amounts to around 1∼4%. The pathogenesis of this peculiar association is currently unknown, leaving a challenging topic for interpretation. - Source: PubMed
Publication date: 2026/04/16
Deguchi MasatoshiWada-Irimada MoyukaTerui HitoshiTakahashi TakuyaAsano Yoshihide - T follicular helper (Tfh) cells regulate B-cell responses within germinal centres primarily via programmed cell death protein 1 (PD-1) and inducible T-cell costimulator (ICOS), whereas CXC chemokine receptor type 5 (CXCR5)-negative T peripheral helper (Tph) cells provide similar support extra-follicularly. Both subsets contribute to the pathogenesis of acetylcholine receptor-antibody-positive myasthenia gravis (AChR-MG). This study investigated the roles of PD-1, ICOS and CXCR5 in T-cell-mediated B-cell activation to identify therapeutic targets for MG. - Source: PubMed
Publication date: 2026/06/21
Çebi MerveÇakar ArmanDurmuş HacerParman YeşimSaruhan-Direskeneli Güher