Anti_Human, mab CXCL5 Source Mouse
- Known as:
- Anti_Human, mab CXCL5 Source Mouse
- Catalog number:
- 101-M355
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Reliatech
- Gene target:
- Anti_Human mab CXCL5 Source Mouse
Related genes to: Anti_Human, mab CXCL5 Source Mouse
- Gene:
- CXCL5 NIH gene
- Name:
- C-X-C motif chemokine ligand 5
- Previous symbol:
- SCYB5
- Synonyms:
- ENA-78
- Chromosome:
- 4q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-09-03
- Date modifiied:
- 2016-10-24
Related products to: Anti_Human, mab CXCL5 Source Mouse
Related articles to: Anti_Human, mab CXCL5 Source Mouse
- [This retracts the article DOI: 10.3727/096504016X14732772150343.]. - Source: PubMed
Publication date: 2026/06/16
- Enhancing innate-adaptive immune crosstalk is key for improving cancer vaccine efficacy. TRIMELVax is a heat shock-conditioned whole-tumor-cell vaccine combining xenogeneic melanoma cell lysate, syngeneic B16F10 melanoma cell lysate, and hemocyanin. Although TRIMELVax elicits robust antitumor responses in preclinical models, the mechanisms underlying its efficacy remain poorly defined. We characterized the early immune events triggered by TRIMELVax in mice using RT-qPCR, high-dimensional flow cytometry, immunohistochemistry, CFSE-based dendritic cell (DC) migration assays, and therapeutic melanoma models with transient neutrophil depletion. TRIMELVax elicited a rapid inflammatory response at the vaccination site, characterized by local upregulation of , and . This response drove an early influx of neutrophils and monocytes, followed by increased accumulation of cDC1, cDC2, and monocyte-derived DCs. Notably, we identified a transient population of neutrophils expressing markers associated with antigen-presenting cells (CD45⁺, CD11b⁺, Ly6G⁺, CD11c⁺, MHC-II⁺) that emerged within 12-24 hours postvaccination. These APC-like neutrophils colocalized with cDC1 at the injection site and subsequently migrated to the popliteal draining lymph nodes (pLN). Neutrophil depletion impaired cDC1 migration, reduced APC accumulation in pLN, and abolished the therapeutic efficacy of TRIMELVax. Together, these findings identify neutrophils as key early regulators of the innate inflammatory environment induced by TRIMELVax and suggest that neutrophils with APC-like features may impact DC trafficking and downstream antitumor immunity. Neutrophils, particularly those with APC-like phenotypes, emerge as promising cellular adjuvant targets for enhancing cancer vaccination strategies, offering a new avenue for rational vaccine design and combination with checkpoint blockade therapies. - Source: PubMed
Publication date: 2026/06/25
Pérez-Baños AmarilisGleisner María AlejandraTittarelli AndrésTapia DanielaCuevas María ElisaMardonez AntoniaTempio FabiánAstaburuaga-García RosarioFlores IvánPereda CristianLladser ÁlvaroGonzález Fermín EValenzuela SebastiánRicca MicaelaBecker María InésBlüthgen NilsAchour AdnaneSalazar-Onfray Flavio - Neurosyphilis has resurged globally, presenting a significant public health threat, yet challenges in early diagnosis persist. This study aims to evaluate the diagnostic value of C-X-C motif chemokine ligand 1 (CXCL1), C-X-C motif chemokine ligand 5(CXCL5), and C-X-C motif chemokine ligand 8 (CXCL8) in cerebrospinal fluid (CSF) for neurosyphilis. - Source: PubMed
Publication date: 2026/06/03
Zhang YanJin YujiaoLiu YuanXue LizhiGu KailongDu WeiLiu ShourongXu Aifang - Degenerative lumbar spine disorders (DLSD), including intervertebral disc disorders (IDD), degenerative spondylolisthesis, and lumbar spinal stenosis (LSS), are major contributors to low back pain and disability. Associations among gut microbiota (GM), inflammatory proteins, and DLSD have been demonstrated in prior studies. Yet, two key questions persist: whether specific circulating inflammatory proteins (IPs) mediate this association, and whether such mediation is shared across different diseases. - Source: PubMed
Publication date: 2026/06/03
Lou YongfuMa DaoyiGan QingquanXu XianyueXiao YimingWang JunzhuoLi ZhibingZhang TaoQi LeiFeng Shiqing - Microwave ablation induces heating of tissue. High energy results in thermal cell death, but low energy treatment without tissue necrosis has been shown to induce cutaneous immunity in an HPV wart model. It is approved as an effective cancer treatment for solid organ cancers, and therefore it is of interest to know if microwave delivered directly to the skin holds potential for treatment of skin cancer. This pilot study focused on transcriptomic profiling of cutaneous melanoma metastases to investigate molecular changes associated with microwave therapy. Seven adult patients with skin metastases from malignant cutaneous melanoma, not resolving on standard treatment, were recruited. Microwave energy was applied to separate melanoma metastases. Morphological, histological, and transcriptomic changes assessed via tissue RNA sequencing were evaluated. Three participants showed complete response, while four showed partial response by histological assessment. In complete responders, skin lesion RNA sequencing after treatment, compared with baseline, identified increased inflammation (CXCL5, CXCL8, IL1A, COL1A1) and downregulated cancer markers (PRAME, S100B, MLANA, STK32A). Compared with partial responders, complete responders showed enrichment of FABP4 and reduced expression of cancer markers. Microwave therapy produced local tumor responses and associated inflammatory transcriptomic changes in complete responders, supporting further clinical evaluation in cutaneous melanoma metastases. - Source: PubMed
Losol PurevsurenO'Driscoll DanielPulido Andres Vallejovon Witzleben AdrianBoukas KonstantinosSommerlad MatthewOttensmeier ChristianArdern-Jones Michael R