Anti_Human, mab Cripto Source Mouse
- Known as:
- Anti_Human, mab Cripto Source Mouse
- Catalog number:
- 101-M341
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Reliatech
- Gene target:
- Anti_Human mab Cripto Source Mouse
Related genes to: Anti_Human, mab Cripto Source Mouse
- Gene:
- TDGF1 NIH gene
- Name:
- teratocarcinoma-derived growth factor 1
- Previous symbol:
- -
- Synonyms:
- CRIPTO, CR, Cripto-1, CR-1
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-08-02
- Date modifiied:
- 2018-10-31
Related products to: Anti_Human, mab Cripto Source Mouse
Related articles to: Anti_Human, mab Cripto Source Mouse
- Metastasis underlies most colorectal cancer (CRC)-related deaths, yet its molecular drivers remain incompletely characterized. This study aims to provide novel insights into the mechanisms underlying CRC metastasis through integrated multiomics and experimental validation. - Source: PubMed
Publication date: 2026/04/20
Li DefuWang HuiYu ZhengpingZhang YuanbingZhang JieTao XiangWang FangpingLuo ShiwenLu Quqin - Neuro-related proteins are promising biomarkers and therapeutic targets for Parkinson's disease (PD), yet their specific roles remain uncertain. - Source: PubMed
Publication date: 2026/02/21
Zhou HangWang ZihaoTan ZixinDeng BinYang WanlinHuang ZifengGuo XingfangLi JintaoWang XinhaoYu YinghuaDeng ChaoZheng WenhuaZhang XuChen XiYue JianhuiYang ChengwuCui XiaoyingPoplawska-Domaszewicz KarolinaChaudhuri K RayZhou ZhidongXiao BinChan Ling-LingFoo Jia NeeTan Eng-KingWang Qing - Digital PCR (dPCR) enables absolute nucleic acid quantification and has been widely adopted for quality control (QC) applications in cell therapy manufacturing. Ensuring patient safety during cell therapy manufacturing requires reliable detection of trace residual cells, such as undifferentiated induced pluripotent stem cells (iPSCs) and virus-producing cells. This study compared qPCR (CFX96 Opus System, Bio-Rad) with two dPCR platforms-the QX200 Droplet Digital PCR System (Bio-Rad) and the QIAcuity Digital PCR System (QIAGEN). For QC evaluation, iPSCs mixed with differentiated cardiomyocytes (CMs) or neural progenitor cells (NPCs) were analyzed using TDGF1, OCT4, and NANOG, while virus-producing 293T cells in CAR-T preparations were targeted using gag and VSVG sequences within the lentiviral packaging plasmid. Mixed samples were serially diluted from 1:1 to 1:10 to evaluate performance across a wide concentration range. Both dPCR platforms and qPCR showed comparable sensitivity and linearity across most dilution points. However, qPCR exhibited more frequent signal loss at low template concentrations. In contrast, dPCR showed reduced variability across dilution intervals, and lower coefficients of variation (CV), indicating more stable quantification at low target levels. Despite minor differences in absolute copy number, both dPCR systems demonstrated comparable analytical performance. These results indicate that, although overall sensitivity and linearity were similar between qPCR and dPCR, dPCR provides more consistent quantification across dilution ranges, supporting its suitability for detecting low-abundance residual cells in cell therapy manufacturing. - Source: PubMed
Publication date: 2026/01/19
Koh Un NaLim Si-Keun - This study investigated Cripto-1 expression, a crucial regulator of epithelial-mesenchymal transition (EMT) and trophoblast differentiation, in term placentas from pregnancies complicated by fetal growth restriction (FGR), compared with healthy term placentas. We hypothesized that Cripto-1 expression is reduced in FGR placentas, reflecting impaired EMT. - Source: PubMed
Publication date: 2025/12/30
Perković PavoDekanić AndreaPerković MarinaLazarević Vesna VukičevićPerković TomislavŠtimac Tea - Glomerular extracellular matrix protein accumulation, mediated largely by mesangial cells(MC), is a defining feature of diabetic kidney disease(DKD). Previously we showed that TGFβ1, a profibrotic cytokine in kidney fibrosis, inhibits expression of the antifibrotic follistatin through induction of microRNA-299a-5p. Whether this microRNA contributes to DKD is unknown. We show that microRNA-299a-5p is increased in mouse and human diabetic kidneys, and by high glucose in primary MC. Overexpression of microRNA-299a-5p in MC increased basal ECM protein production. Conversely, microRNA-299a-5p inhibition prevented the glucose-induced profibrotic response. Bioinformatics screening revealed that cripto-1 is also a target of microRNA-299a-5p. Induction of microRNA-299a-5p by high glucose mediated the MC fibrotic response by inhibiting follistatin and cripto-1 which led to increased activin A and TGFβ1 signaling. In vivo, microRNA-299a-5p inhibition reduced clinical markers of DKD, and was associated with increased expression of follistatin and cripto-1. Thus, microRNA-299a-5p is an important mediator of glucose-induced profibrotic responses in diabetic kidneys. - Source: PubMed
Publication date: 2025/12/11
Nmecha Ifeanyi KGao BoMacDonald MelissaZhang DanChoi JasonTrink JackieBajwa UroojKrepinsky Joan C