Anti_Human, mab CD64 Source Mouse
- Known as:
- Anti_Human, mab CD64 Source Mouse
- Catalog number:
- 101-M313
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Reliatech
- Gene target:
- Anti_Human mab CD64 Source Mouse
Related genes to: Anti_Human, mab CD64 Source Mouse
- Gene:
- FCGR1A NIH gene
- Name:
- Fc fragment of IgG receptor Ia
- Previous symbol:
- -
- Synonyms:
- CD64, CD64A
- Chromosome:
- 1q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-03
- Date modifiied:
- 2019-04-23
- Gene:
- FCGR1B NIH gene
- Name:
- Fc fragment of IgG receptor Ib
- Previous symbol:
- -
- Synonyms:
- CD64b
- Chromosome:
- 1p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-03
- Date modifiied:
- 2016-01-13
- Gene:
- FCGR1CP NIH gene
- Name:
- Fc fragment of IgG receptor Ic, pseudogene
- Previous symbol:
- FCGR1C
- Synonyms:
- CD64c
- Chromosome:
- 1q21.1
- Locus Type:
- pseudogene
- Date approved:
- 1992-12-03
- Date modifiied:
- 2016-01-13
Related products to: Anti_Human, mab CD64 Source Mouse
Related articles to: Anti_Human, mab CD64 Source Mouse
- The perturbed genes from transcriptomes are often presented in terms of relative expressions against control samples. However, the probe signal values (PSVs) of genes, implying protein abundances, are often ignored. Here, we explored the PSVs in tuberculosis (TB)-relevant signature genes. The signatures from -infected THP-1 cells were defined as induced (T-i, with a derived T-iNet) and repressed (T-r). The signature from human blood was defined as a pulmonary TB (PTB)-specific signature (PTBsig). The analysis showed that before infection, T-i and T-iNet had lower PSVs and T-r genes had average PSVs. In the blood of healthy donors, PTBsig (divided into up-regulated PTBsigUp and down-regulated PTBsigDn) displayed average PSVs. This was partly due to masking by the cellular heterogeneity of blood; diverse PSVs were seen in constituent cell populations (CD4/8+ T, monocytes and neutrophils). Specifically, the PSVs of PTBsigUp in the neutrophils of healthy donors were higher (implying higher protein abundances), and much higher in the neutrophils of PTB (implying excessive protein abundances). Based on the PSV patterns of PTBsigUp in four cell populations, we identified three representative highly homologous genes (, and the pseudogene , which were often poorly distinguished), of which the summed PSVs were the highest in the neutrophils of PTB patients and healthy donors. The three genes were all up-regulated and responsive to chemotherapy in the blood of PTB, as validated in an RNA-seq-based analysis. This PSV-based study confirms the excessive involvement of neutrophil FCGR1 in PTB. - Source: PubMed
Publication date: 2020/02/14
Wu KangLi MengChen Zhen-YanLowrie Douglas BFan Xiao-Yong