Human ccbe1 (fragment) Source Insect cells
- Known as:
- Human ccbe1 (fragment) Source Insect cells
- Catalog number:
- 300-058
- Product Quantity:
- 20 µg
- Category:
- -
- Supplier:
- Reliatech
- Gene target:
- Human ccbe1 (fragment) Source Insect cells
Related genes to: Human ccbe1 (fragment) Source Insect cells
- Gene:
- CCBE1 NIH gene
- Name:
- collagen and calcium binding EGF domains 1
- Previous symbol:
- -
- Synonyms:
- FLJ30681, KIAA1983
- Chromosome:
- 18q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-18
- Date modifiied:
- 2019-04-23
Related products to: Human ccbe1 (fragment) Source Insect cells
Related articles to: Human ccbe1 (fragment) Source Insect cells
- Lymphangiogenesis is essential for tumor lymphatic metastasis, yet the molecular mechanisms governing the activation of its key cytokine, VEGF-C, remain unclear. Herein, we identified a circRNA, circFOCAD, through VEGF-C maturation-associated multiple transcription sequencing. CircFOCAD is overexpressed in lymph node (LN)-metastatic bladder cancer (BCa) and is associated with poor prognosis. In footpad popliteal LN metastasis and orthotopic BCa models, circFOCAD enhances VEGF-C-dependent lymphangiogenesis and LN metastasis in BCa. Mechanistically, circFOCAD potentiates pro-VEGF-C cleavage by facilitating the expression of CCBE1 and its newly identified partner, the metalloprotease ADAM10. Specifically, circFOCAD promotes ADAM10 promoter H3K9 acetylation by recruiting YBX1. ADAM10 requires CCBE1 as a scaffold, binding at residue R301/R302, to interact with N-terminal propeptide of pro-VEGF-C at residue E58, provoking VEGF-C maturation and sustaining lymphangiogenesis in BCa. Clinically, neutralizing antibodies against CCBE1 and ADAM10 diminished the LN metastatic of BCa in a patient-derived xenograft (PDX) model. Our findings indicate that circFOCAD acts as an initiator of VEGF-C maturation and may represent a promising therapeutic target in LN metastatic BCa. - Source: PubMed
Publication date: 2026/06/18
Liu DaiyinPang MingruiLi YuanlongLiu ZhicongBi YifanZheng HanhaoLi WenjieLi PeixinAn MingjieChen JianchengLin YanJiang ChunPang JunHuang HuashengLin TianxinChen Changhao - - Source: PubMed
Publication date: 2026/05/07
Tian Guang-AngZhu Chun-ChaoZhang Xiao-XinZhu LeiYang Xiao-MeiJiang Shu-HengLi Rong-KunTu LinWang YangZhuang ChunHe PingLi QingCao Xiao-YanCao HuiZhang Zhi-Gang - Hennekam lymphangiectasia-lymphedema syndrome (HKLLS) is an autosomal recessive disorder, caused by biallelic variants in CCBE1, FAT4, and ADAMTS3 genes. We herein report a 15-month-old male with peripheral lymphedema, facial dysmorphism, camptodactyly and generalized hypotonia. Solo exome sequencing revealed a homozygous splice site variant, c.12479+3A>G in intron 14 of FAT4 (NM_001291303.3). Reverse transcriptase-PCR (RT-PCR) was performed using cDNA isolated from patient-derived fibroblasts, which revealed aberrant splicing. This study provides a report of an additional family with a novel biallelic splice site variant in FAT4 which disrupts the normal splicing of the FAT4 mRNA, leading to aberrant splicing causing a milder form of HKLLS2. - Source: PubMed
Publication date: 2026/04/16
Mascarenhas SelindaGupta YashaviK A AkhilPande ShrutiShaikh HuzailGirisha Katta MohanRadhakrishnan PeriyasamyShukla Anju - Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, and identifying accessible blood-based biomarkers is therefore a clinical priority. Given the involvement of oxidative stress and immune cell dysfunction in atherosclerosis, we investigated whether mitochondrial reactive oxygen species (mROS) production in peripheral blood mononuclear cells (PBMCs) is associated with CAD. This exploratory study analyzed PBMCs from 40 BioHEART-CT participants with or without CT-defined CAD using MitoSOX-based flow cytometry. In parallel, single-cell RNA sequencing (scRNA-seq) was conducted in the same individuals to investigate differential expression of CCBE1, a recently implicated gene in cardiovascular disease, across PBMC populations. Overall, mROS levels in PBMCs and their major cellular subtypes did not show consistent or meaningful associations with CAD status or with modifiable cardiovascular risk factors. Small, subgroup-specific signals-such as moderate association between lymphocyte mROS and coronary artery calcium score in males, and a modest inverse association between monocyte mROS and hypertension-were exploratory and not uniform across analyses. scRNA-seq analysis did not identify a distinct CCBE1 expression signature in PBMCs. These findings indicate that PBMC-derived mROS is unlikely to serve as a useful cross-sectional biomarker of CAD in stable populations. - Source: PubMed
Lee W EugeneHenry AlbertSpenceley Eleanor RuthSagi-Zsigmond EszterBowen BlakeNguyen Tung VGray Michael PGrieve Stuart MPowell Joseph EFigtree Gemma A - Autologous fat grafting is limited by unpredictable resorption and complications, largely due to inadequate revascularization and persistent inflammation. The molecular mechanisms underlying these processes remain poorly understood. - Source: PubMed
Publication date: 2026/01/08
Wu ShuZhu Yuan-ZhengZhang Min-ChenZeng Xing-HongShi Chen-LongGao HaiLiu Xue-FeiZhang You-LaiGan Pei-DongYi Yang-Yan