AmpliKit MTHFR C677T
- Known as:
- AmpliKit MTHFR C677T
- Catalog number:
- 0503
- Product Quantity:
- 1 kit
- Category:
- -
- Supplier:
- Sacace
- Gene target:
- AmpliKit MTHFR C677T
Related genes to: AmpliKit MTHFR C677T
- Gene:
- MTHFR NIH gene
- Name:
- methylenetetrahydrofolate reductase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p36.22
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-15
- Date modifiied:
- 2019-04-23
Related products to: AmpliKit MTHFR C677T
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- The convergence of genomic science and culinary arts has led to a new paradigm in wellness tourism: nutrigenomic retreats. These programs merge genetic insights with tailored diets, immersive culinary education, and holistic wellness practices. While nutrigenomics and personalized nutrition are advancing rapidly, translation of gene-diet knowledge into structured, real-world experiential models remains underexplored. This paper proposes a conceptual and translational framework for nutrigenomic retreats, integrating scientific advances in personalized nutrition with gastronomy-driven wellness experiences. - Source: PubMed
Caglas RecepYilmaz Vural - Employing a narrative review approach, this article examines the value of combining homocysteine (Hcy) with multiple indicators for screening pregnancy complications. Hcy serves as a key biomarker in one-carbon metabolism and vascular endothelial function. Elevated Hcy levels are significantly correlated with adverse pregnancy outcomes, including preeclampsia (PE), fetal growth restriction (FGR), gestational diabetes mellitus (GDM), and intrahepatic cholestasis of pregnancy (ICP). Hcy levels are influenced by nutritional factors (folate, vitamin B12) and genetic factors (MTHFR polymorphisms). However, the predictive power of Hcy alone is limited due to variations in gestational age, ethnicity, nutritional status and genetic background. Recent studies have therefore explored combined screening strategies: Hcy together with platelet parameters helps differentiate the risk of ICP from that of GDM; adding uterine artery (UtA) Doppler ultrasonography improves the diagnostic sensitivity for detecting PE and FGR; integrating glycolipid metabolic markers (Glycosylated Serum Protein, Cystatin-C, apoB/apoA1) provides additional predictive value for adverse outcomes in GDM. Positioning Hcy as a functional endpoint of gene-nutrient interactions and combining it with nutritional and genetic assessments may facilitate early warning of pregnancy complications and enable individualized intervention. - Source: PubMed
Publication date: 2026/05/19
An ChunliTang YanYin ChunliWang MinZuo Guihua - This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high-quality data, expert consensus was additionally obtained through a modified Delphi process. Remethylation disorders are rare inherited conditions that disrupt the methionine-homocysteine cycle and consecutively impair essential methylation dependent metabolic pathways. Remethylation disorders are caused by defects in the cobalamin or folate metabolism. The disorders typically result in elevated homocysteine and often low methionine; combined cobalamin-related defects also affect mitochondrial methylmalonic acid clearance. The cblC-MMACHC defect is the most common cobalamin-related remethylation disorder. Early-onset patients usually present with severe neurological and eye symptoms. Late-onset cases show variable symptoms (e.g., psychiatric, renal, thromboembolic events). Plasma total homocysteine, methionine, methylmalonic acid, serum vitamin B12 (and folates) should be assessed in suspected cases. Early detection through newborn screening is associated with improved clinical outcomes. Betaine as first-line therapy for methylenetetrahydrofolate reductase deficiency and parenteral hydroxocobalamin for cobalamin-related defects have reduced mortality and morbidity. Total homocysteine, methionine (and methylmalonic acid) should be kept as close to normal values as achievable. Emerging evidence suggests that early use of high-dose hydroxocobalamin (> 0.35 mg/kg/day) may improve neurocognitive impairment and may ameliorate eye disease in severe cobalamin-related defects. A major limitation in current practice is the lack of availability of high concentration hydroxocobalamin formulations for parenteral administration. - Source: PubMed
Olivieri GiorgiaBordugo AndreaBurnyte BiruteCostetti AlessandroCouce Maria-LuzDiogo LuisaFeillet FrancoisFroese D SeanGreco BenedettaGueant Jean-LouisHannibal LucianaHörster FriederikeKožich ViktorLa Marca GiancarloManoli IriniMochel FannyOrazi LorenzoPérez BelénSchiff ManuelSchwahn Bernd CSchwartz IdaStepien Karolina MSykut-Cegielska JolantaTangeraas TrineZetterström Rolf HDionisi-Vici CarloHuemer Martina - The progression of non-small cell lung cancer (NSCLC) is driven by metabolic plasticity and evasion of apoptotic surveillance, mechanisms that remain incompletely understood. Here, through integrated transcriptomic-metabolomic profiling, molecular interaction mapping, and functional validation, we unveiled a dual regulatory mechanism governed by the MTHFR/SLC25A26 axis that suppresses NSCLC. Clinical cohort analyses revealed concurrent downregulation of MTHFR and SLC25A26 in NSCLC tissues, which strongly correlated with poor prognosis. Mechanistically, MTHFR directly binds and stabilizes SLC25A26, whereas SLC25A26 accelerates SHMT2 degradation via the ubiquitin-proteasome pathway and concurrently suppresses AKT-driven MYB transcriptional activation. This coordinated disruption of serine/one-carbon metabolism and oncogenic signaling significantly inhibited tumor growth in patient-derived xenograft models. Crucially, we identified SLC25A26 as a mitochondrial transporter-ubiquitin adapter hybrid that destabilizes SHMT2 through ubiquitination, whereas its interaction with MTHFR prevents metabolic dysregulation induced by the C677T mutation. Our findings establish the MTHFR/SLC25A26 axis as a master regulator of metabolic-transcriptional crosstalk, providing a therapeutic framework for targeting enzyme stability and kinase signaling in NSCLC treatment.The MTHFR/SLC25A26 axis suppresses NSCLC progression through catalytic activity-dependent stabilization of SLC25A26 by MTHFR, where SLC25A26 functions as a ubiquitin adapter to degrade SHMT2 while concurrently repressing AKT-MYB-driven SHMT2 transcription; clinical downregulation of this axis predicts poor prognosis, and MTHFR overexpression inhibits tumor growth in vivo. - Source: PubMed
Publication date: 2026/06/01
Li LanYang YiRanWang ShiQingLi DanChen ChuMaoMu XinMeiWu JiaXinYuan Jin - Aspergillus carbonarius-induced sour rot is an important postharvest disease affecting grapes. Previous study demonstrated that cAMP induction boosts the biocontrol efficiency of Sporidiobolus pararoseus Y16 in combating postharvest sour rot of grapes. Oxidative stress experienced by the antagonistic yeast at fruit wound sites is a key factor limiting its biocontrol efficacy. This research investigated how inducing yeast cells with cAMP effects on tolerance to oxidative stress and explored underlying mechanisms. Results showed that cAMP treatment significantly increased yeast survival rate under exogenous oxidative stress. Physiological analysis revealed a synergistic enhancement on enzyme activities, such as SOD, POD, and CAT in cAMP-induced yeast, accompanied by reduced levels of reactive oxygen species (ROS) under HO stress in vitro and at grape wound sites. Furthermore, levels of protein carbonylation, malondialdehyde (MDA) and trehalose were decreased. Transcriptomic analysis identified upregulation of key genes involved in one-carbon metabolism, thiamine biosynthesis, and amino acid metabolism, such as MTHFR, THI5, ALDH7A1, CTH, and proB, which collectively promoted NADPH regeneration, glutathione (GSH) synthesis, aldehyde detoxification, and direct ROS scavenging. In conclusion, cAMP induction activates a multilayered antioxidant defense system in S. pararoseus Y16 through metabolic reprogramming, significantly enhancing its adaptability to the oxidative stress microenvironment of grapes. These findings provide a theoretical basis for optimizing the performance of biocontrol yeasts, demonstrating their significant application prospects. - Source: PubMed
Publication date: 2026/05/20
Zhao YuZhang XiaoyunDhanasekaran SolairajGodana Esa AbisoLi JunZhang ZhenpengZhao LinaZhang Hongyin