KITLG 80441C_T Real_TM NEW Real Time Amplification kit 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools see Cat. No TV_XXX
- Known as:
- KITLG 80441C_T Real_TM NEW Real Time Amplification reagent 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools Cat. TV_XXX
- Catalog number:
- I03-50FRT
- Product Quantity:
- 1 kit
- Category:
- -
- Supplier:
- Sacace
- Gene target:
- KITLG 80441C_T Real_TM NEW Real Time Amplification kit 50 Tests IL_ Equipment tools see Cat. TV_XXX
Related genes to: KITLG 80441C_T Real_TM NEW Real Time Amplification kit 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools see Cat. No TV_XXX
- Gene:
- CAT NIH gene
- Name:
- catalase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
- Gene:
- KITLG NIH gene
- Name:
- KIT ligand
- Previous symbol:
- MGF
- Synonyms:
- SCF, SF, Kitl, KL-1, FPH2, SLF, DFNA69
- Chromosome:
- 12q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-04
- Date modifiied:
- 2019-04-23
Related products to: KITLG 80441C_T Real_TM NEW Real Time Amplification kit 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools see Cat. No TV_XXX
Related articles to: KITLG 80441C_T Real_TM NEW Real Time Amplification kit 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools see Cat. No TV_XXX
- RUNX2 (Runt-related transcription factor 2) is a master regulator of osteogenesis, and its genetic mutations are associated with ~65% cases of cleidocranial dysplasia (CCD), an autosomal dominant abnormal bone development disorder in humans with defective intramembranous bone formation. However, how these mutations affect bone formation remains to be investigated. Here, we report that RUNX2 interacts with the F-box protein JFK and is destabilized by the SKP1-CUL1-JFK E3 ubiquitin ligase complex (SCF). We find that several CCD-associated mutations of RUNX2 acquire an increased affinity toward SCF thus an accelerated proteasomal degradation. We demonstrate that SCF-mediated RUNX2 degradation suppresses osteoblast differentiation. Consistently, Jfk-null mice exhibit increased trabecular bone volume and bone mineral density and are resistant to Runx2 haploinsufficiency-induced CCD-like syndrome. Interestingly, RUNX2 binds to the JFK promoter and represses its transcription, establishing a feedback loop to promote osteoblast differentiation, and remarkably, the CCD-associated RUNX2 mutants also display an impaired transcription repression of JFK. Our study demonstrates SCF as an E3 ligase for RUNX2 and uncovers a feedback regulatory loop between SCF and RUNX2 that is implemented in bone development and implicated in CCD, supporting the pursuit of JFK as a potential target to ameliorate CCD-like syndrome. - Source: PubMed
Publication date: 2026/09/16
Shang ZesenZhang YueLiu YangYuan XinyiWang JichuangFan DongweiZou DaTie DazhaoPei FeiZhao HongshanZheng ShuguoTang XinjingLi WeishiHe Lin - Pregnancy elicits extensive remodeling of the mammary gland to establish the alveolar network required for lactation, yet the cellular programs underlying this transition in pigs remain poorly resolved. Here, we generated a single-cell transcriptomic atlas of the porcine mammary gland across gilt, late pregnancy, and post-lactational stages. Differential expression analyses identified epithelial, fibroblast and endothelial compartments as the most dynamic during pregnancy, motivating higher-resolution analyses of these lineages. Epithelial trajectories toward alveolar fate exhibited induction of fibrillar collagen programs, including , and , implicating epithelial contributions to extracellular matrix assembly. Fibroblast analysis revealed a PGLYRP1 fibroblast subtype enriched for the chemokines , and , suggesting a role in immune cell recruitment. Endothelial cells undergo stage-specific metabolic reprogramming, with late pregnancy characterized by increased expression of glycolysis-associated genes, including , and , as well as lipid metabolism-related genes such as , and . Cross-species comparison revealed conserved cellular identities and key molecular features ( , , ) across human, pig, and mouse mammary glands. Together, this atlas delineates the cellular logic underlying pregnancy-associated remodeling and serves as a resource for elucidating transcriptomic changes in the porcine mammary gland. - Source: PubMed
Yang Si-YuYao Tian-XiongHuang Lu-Sheng - This study aimed to develop a mitochondrial and hematopoiesis-related differentially expressed genes (MH-related DEGs) signature for Myelodysplastic syndromes (MDS) diagnosis and to characterize its regulatory network and immune microenvironment. - Source: PubMed
Publication date: 2026/09/02
Liu XianchuanZhang HongLi Xiangzhu - Chronic exposure to the widely used organophosphate pesticide chlorpyrifos has been associated with reproductive dysfunction; however, the early subclinical events preceding overt reproductive dysfunction remain poorly understood due to cell-specific and non-monotonic responses to the toxicant. The present study investigated the effect of chronic CPF exposure on the spermatogenic niche and sperm epigenome in a mouse model. Despite the absence of detectable oxidative stress or reproductive toxicity, chronic CPF exposure induced significant changes in the testicular microenvironment. Testicular proteomic analysis revealed dysregulated expression of proteins involved in extracellular matrix remodeling in CPF-exposed mice. These changes were associated with increased expression of Ctnnb1 and Axin1 indicating modulation of β-catenin-associated signaling in the testis. Furthermore, CPF exposure was associated with dysregulation of Sertoli cell function characterized by a significant reduction in Kitlg expression, increased c-kit levels, and reduced expression of the gap junction protein Connexin 43. CPF exposure also led to a significant dose-dependent increase in the expression of Tet1 suggesting altered epigenetic regulation in the testis. Interestingly, there was a trend toward increased sperm DNA methylation in CPF-exposed mice. Overall, these findings reveal that chronic CPF exposure induces early remodeling of the spermatogenic niche and alters testicular epigenetic regulation prior to overt reproductive dysfunction, identifying the Sertoli cell-extracellular matrix axis as a potential early target underlying CPF-induced testicular toxicity. - Source: PubMed
Publication date: 2026/08/20
Mansukhani MeenakshiTasneem RuqaiyaSen Sharma Souvik - MicroRNAs regulate gene expression post-transcriptionally, yet target prediction faces a credibility gap: published methods drop sharply against CLIP-seq-validated negatives. We present DeepExoMir, a deep learning framework integrating frozen RiNALMo RNA language model embeddings with biologically informed features. Under a dual-probe ablation protocol on three miRBench test sets, DeepExoMir reaches mean AU-PRC 0.855, surpassing eight retrained baselines (paired bootstrap p<0.001). Evolutionary conservation and duplex structure prove largely redundant with language-model priors, motivating a structure-free Lite variant (0.863). On nine exosomal miRNAs from a companion melanogenesis study, DeepExoMir recovers literature-validated targets and ranks canonical pigmentation regulators (KITLG, MITF, TYRP1) in the top 5%. - Source: PubMed
Publication date: 2026/07/10
Lin Wen-HsienHsiung Chia-NiLien Wen-YuSieber Martin