ADRB1 Ser49Gly Real_TM NEW Real Time Amplification kit 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools see Cat. No TV_XXX
- Known as:
- ADRB1 Ser49Gly Real_TM NEW Real Time Amplification reagent 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools Cat. TV_XXX
- Catalog number:
- H03-50FRT
- Product Quantity:
- 1 kit
- Category:
- -
- Supplier:
- Sacace
- Gene target:
- ADRB1 Ser49Gly Real_TM NEW Real Time Amplification kit 50 Tests IL_ Equipment tools see Cat. TV_XXX
Related genes to: ADRB1 Ser49Gly Real_TM NEW Real Time Amplification kit 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools see Cat. No TV_XXX
- Gene:
- ADRB1 NIH gene
- Name:
- adrenoceptor beta 1
- Previous symbol:
- ADRB1R
- Synonyms:
- -
- Chromosome:
- 10q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2015-08-24
- Gene:
- CAT NIH gene
- Name:
- catalase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
Related products to: ADRB1 Ser49Gly Real_TM NEW Real Time Amplification kit 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools see Cat. No TV_XXX
Related articles to: ADRB1 Ser49Gly Real_TM NEW Real Time Amplification kit 50 Tests RG,iQ,SC,MX,A,B,LC,IL_ Equipment tools see Cat. No TV_XXX
- To reconnoitre the mechanism of Abietic acid (AA) in diabetes by and experiments. Using GeneCards, diabetes gene targets were obtained. The protein-protein interaction and network topology analysis were performed using the String platform and Cytoscape 3.7.2. The enrichment analysis was done by Shiny GO. The docking was by Autodeck. Diabetes was induced by injecting STZ (55 mg/kg, i.p once) in Sprague-Dawley rats. The parameters included glucose, lipids, blood pressure, ECG, OGTT, kidney and cardiac markers, liver enzymes, AMPK, Nrf2, PPAR-γ, TLR-4, oxidative markers, LVF tests, and histopathology. AA interacts with 15 important targets (PIK3CD, MAPK1, NF-κB, mTOR, STAT3, GRIN1, ITGB3, ACACA, HSP90AB1, SERPINE1, ADRB1, ULK1, TLR4, CTSD, CDK5). The signalling pathways, like insulin, MAPK1, TLR, AMPK, JAK-STAT, are associated with these proteins. In docking, the highest affinity of AA was observed for ITGB3 (- 8.1), TLR4 (- 7.8), and ACACA (- 7.3). In rats, AA(40 and 80 mg/kg) decrease hyperglycaemia and hyperinsulinemia, improves glucose tolerance, normalize blood pressure, combat dyslipidaemia (decrease triglyceride, total cholesterol, LDL, increase HDL), preserves myocytes and ventricular function (decrease troponin-I, LDH, CK-MB, LVEDP, normal ECG), hepatoprotective (decrease AST, ALT), reno-protective (decrease creatinine, urea, uric acid) and combat oxidative stress (decrease MDA, increase SOD, catalase). Nrf2, AMPK, and PPAR γ levels were increased while TLR-4 levels were decreased after AA treatment. The study is supported by the preserved histopathological architecture of pancreatic, renal, hepatic, and cardiac cells. The present study preliminarily clarifies that AA exhibits therapeutic potential in preclinical models through multitargets and multi-pathways (Nrf/TLR4/PPAR γ), which points out a new direction for further research and clinical application. - Source: PubMed
Publication date: 2026/09/24
Mishra AkashShah Hital - Improved access to genetic testing is accelerating identification of variants underlying common sleep traits and rare Mendelian disorders. This review highlights advances over the past two years. - Source: PubMed
Publication date: 2026/09/09
Mani HaritaCuddapah Vishnu Anand - Conotruncal heart defects (CTDs) account for approximately one-third of all congenital heart defects. Elevated levels of phosphatidylinositol (3,4,5)-trisphosphate (PIP3) may contribute to CTD pathogenesis. PIP3 plays a pivotal role in mechanotransduction-based biological processes and remodeling of cardiac cytoskeletal proteins. Here, we aimed to evaluate the efficacy of the 322PESB derivative compound as a molecular regulator that antagonizes PIP3 binding pleckstrin homology (PH) domain of the Akt protein using mesenchymal stem cell-derived cardiomyocyte. Human adipose-derived MSCs (Ad-MSCs) were isolated. Immunophenotypic features of the hAd-MSCs were characterized according to minimal criteria of the international society for cellular therapy (ISCT) including immunophenotyping and trilineage differentiation potential. Subsequently, the differentiated hAd-MSCs were cultured in cardiomyogenesis-inducing medium. Successfully differentiated cardiomyocytes were assessed by measuring the expression levels of cardiomyocyte-specific genes using RT-qPCR. PIP3-primed cardiomyocytes were treated with 10 and 30 μmol/L of a 322PESB derivative molecule. The results showed a typical MSCs with high expression levels of CD73 (77.55%), CD90 (87.59%) and CD105 (91.88%) and that was accompanied by low expression levels of CD34 (0.59%) and CD45 (1.78%). After 21 days of MSC culture, cardiomyocyte-like cells with prominent striations were observed. Subsequent confirmation by RT-qPCR quantification of ADRB1 and MLC2a expression levels showed an average increase of 2.9-fold and 2.1-fold, respectively, in induced cardiomyocytes. Compared with the untreated control, PIP3 ELISA assay showed a significant increase in PIP3 levels in PIP3(10 nmol/L)-primed cardiomyocytes treated with 10 and 30 μmol/L of the 322PESB molecule derivative by 485.804 and 3564.164 ng/mL, respectively. In this study, we conducted the first promising molecular regulator with potential therapeutic implications for CTD patients. Further functional animal model and clinical phase studies are recommended. - Source: PubMed
Publication date: 2026/07/23
Fayez AlaaeldinEsmaiel Nora NRaouf Haiam AbdelAboelenin Mohamad MAly Riham MNour Eldeen Ghada - Nicotine, a major tobacco metabolite and persistent environmental pollutant, is epidemiologically associated with breast cancer risk, yet its non-classical carcinogenic molecular mechanisms and prognostic value remain unclear. This study was designed to systematically elucidate the potential targets and molecular mechanisms underlying the prognostic impact of nicotine on breast cancer, alongside developing an interpretable prognostic risk model. - Source: PubMed
Publication date: 2026/07/21
Weng JunyanOu CaifengYi JiaminYang HuanChen ChiweiHuang Mei - Pharmacogenomics-guided therapy is a promising approach for optimizing antihypertensive treatment response; however, robust real-world data from South Asian and particularly Pakistani populations remain scarce. Understanding genotype-drug response relationships in this underrepresented population is essential to inform context-specific precision prescribing strategies. - Source: PubMed
Publication date: 2026/09/11
Alsubaie NawalIlyas MuhammadShah Zafar AliBinsaleh Ammena YAlrossies Amani SAlmazyad Fahad A