MTB Real_TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) and isoniazide (INH) in genes rpoB 531, katG 315, inhA 209) 50 Tests RG, iQ, MX, SC, A_ Equipment tools
- Known as:
- MTB Real_TM Resistance 4 (Multiplex PCR test kit preamplification resistance rifampicine (RIF) isoniazide (INH) genes rpoB 531, katG 315, inhA 209) 50 Tests RG, iQ, MX, SC, A_ Equipment tools
- Catalog number:
- B422-50FRT
- Product Quantity:
- 1 kit
- Category:
- -
- Supplier:
- Sacace
- Gene target:
- MTB Real_TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) isoniazide (INH) genes rpoB 531 katG 315 inhA 209) 50 Tests A_ Equipment tools
Related genes to: MTB Real_TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) and isoniazide (INH) in genes rpoB 531, katG 315, inhA 209) 50 Tests RG, iQ, MX, SC, A_ Equipment tools
- Gene:
- ACSF2 NIH gene
- Name:
- acyl-CoA synthetase family member 2
- Previous symbol:
- -
- Synonyms:
- FLJ20920, ACSMW
- Chromosome:
- 17q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2015-08-26
- Gene:
- ANGPTL8 NIH gene
- Name:
- angiopoietin like 8
- Previous symbol:
- C19orf80
- Synonyms:
- TD26, RIFL
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2011-08-04
- Date modifiied:
- 2015-11-11
- Gene:
- BDH2 NIH gene
- Name:
- 3-hydroxybutyrate dehydrogenase 2
- Previous symbol:
- DHRS6
- Synonyms:
- UCPA-OR, FLJ13261, UNQ6308, PRO20933, SDR15C1
- Chromosome:
- 4q24
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-22
- Date modifiied:
- 2016-12-12
- Gene:
- C8orf33 NIH gene
- Name:
- chromosome 8 open reading frame 33
- Previous symbol:
- -
- Synonyms:
- FLJ20989
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-19
- Date modifiied:
- 2017-07-12
- Gene:
- CCDC30 NIH gene
- Name:
- coiled-coil domain containing 30
- Previous symbol:
- -
- Synonyms:
- FLJ20972, PFD6L, LOC728621
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 2009-07-09
- Date modifiied:
- 2015-08-24
Related products to: MTB Real_TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) and isoniazide (INH) in genes rpoB 531, katG 315, inhA 209) 50 Tests RG, iQ, MX, SC, A_ Equipment tools
Related articles to: MTB Real_TM Resistance 4 (Multiplex PCR preamplification and resistance for rifampicine (RIF) and isoniazide (INH) in genes rpoB 531, katG 315, inhA 209) 50 Tests RG, iQ, MX, SC, A_ Equipment tools
- The simultaneous existence of multidrug-resistant pulmonary tuberculosis (MDR-PTB) and type 2 diabetes mellitus (T2DM) represents a rising threat in high-burden countries such as India. Diabetes has been associated with impaired immune responses and delayed bacteriological clearance, thereby compromising treatment outcomes in patients with multidrug-resistant tuberculosis receiving all-oral longer regimens. - Source: PubMed
Publication date: 2026/09/20
Vats YogitaVerma Ajay KumarBajpai JyotiKant SuryaJain ParulBajaj DarshanSrivastava AnandKushwaha Ram Avadh SinghKumar SantoshGarg RajivKumar AnkitPradhan Akshyaya - The incidence of pediatric urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) has increased worldwide; however, optimal empirical treatment strategies remain controversial. This review addresses the prevalence, virulence factors, clinical impacts, and antibiotic management of UTIs caused by ESBL-PE in children. The prevalence of ESBL-PE among pediatric UTI isolates exceeds 20% in many regions, including Korea. No significant differences exist in the clinical manifestations between ESBL(+) UTIs and other UTIs. Despite in vitro resistance, third-generation cephalosporins frequently achieve therapeutic success because of their high urinary drug concentrations. Based on the patient's condition and risk factors, an initial empirical antibiotic should be selected, and early de-escalation and carbapenem-sparing strategies are essential to balance treatment efficacy and resistance prevention. Therefore, Korean guidelines for the treatment of pediatric UTIs are required. - Source: PubMed
Publication date: 2025/10/27
Park JisunJoo Eun YoungLee Ji-EunKim Su Jin - Fermented foods represent complex microbial ecosystems in which spore-forming Bacillus species persist due to their stress tolerance and metabolic versatility. In the present study, whole-genome sequencing was applied to characterize Bacillus paranthracis SM02, a strain isolated from a traditional fermented sword bean food, with the aim of resolving its taxonomic position and genomic features related to adaptation and biosafety. Whole genome sequencing generated a 5.50 Mb draft genome assembled into 65 contigs with an N50 of 257,567 bp and a GC content of 35.13%, comprising 5,567 predicted protein-coding genes. Average nucleotide identity values exceeding 95% with reference genomes and phylogenomic analysis based on conserved orthologs confirmed the placement of SM02 within the B. paranthracis lineage. Genome annotation identified 35 AMR genes, including putative resistance determinants such as fosB and bcrA-C, along with conserved antibiotic target-associated genes such as gyrA, gyrB, rpoB, and mprF. These findings represent genomic predictions and do not by themselves establish phenotypic antimicrobial resistance. Virulence-associated genes such as nheA, nheB, nheC, alo, inhA, codY, and sigB, along with oxidative stress response genes (sodA, sodC), were detected. Genes linked to biofilm-associated lifestyles, including luxS, lsrR, rpoN, hfq, and polysaccharide metabolism genes (glgA, glgC), were also present. Pan-genome analysis of sixteen B. paranthracis genomes revealed an open pan-genome comprising approximately 7,500-8,000 gene families with a conserved core of nearly 3,900 gene families, while SM02 contained 1,086 accessory and 133 strain-specific genes. Overall, the results revealed a conserved genomic backbone coupled with a flexible accessory genome, suggesting genomic features that may contribute to adaptation within the fermented food environment. - Source: PubMed
Publication date: 2026/09/23
Gowri Shankar JaganathanSudharsan RajkumarLyngdoh MebanjopUmbon DenyoungChanu Thokchom ThajamanbiSenthil Kumar NachimuthuSowmya PulapetMarkkandan KesavanVaiphei S Thangminlal - Continuous monitoring of plant metabolic dynamics remains challenging because existing sensing interfaces often fail to maintain stable mechanical coupling with deformable plant tissues during prolonged electrochemical measurements. Here, a spiral-interlocking microneedle electrode (SI-MNE) is presented for long-term in planta glucose monitoring through mechanically persistent tissue anchoring and minimally invasive biointerfacing. Unlike conventional conical or array-type microneedles that suffer from limited interfacial stability and motion-induced signal fluctuations, the SI-MNE employs a helical geometry that enables rotation-assisted insertion and 3D interlocking within plant tissue, thereby substantially enhancing mechanical retention. Cyclic-voltammetry-derived interfacial capacitance progressively increased during rotational insertion and reached a maximum under full-locking conditions, indicating enhanced electrochemical contact formation. Mechanical testing demonstrated approximately 10-fold higher pull-out resistance compared with conventional conical microneedles, while optical coherence tomography directly visualized stable insertion of the spiral architecture within plant tissue. To establish electrochemical glucose sensing functionality, a multilayer sensing interface consisting of a conductive carbon layer, PEDOT:PSS/Pt nanoparticle catalytic layer, and chitosan/glucose oxidase enzymatic layer was conformally integrated onto the spiral surface. The SI-MNE exhibited concentration-dependent amperometric glucose responses across 1-100 mM with a sensitivity of 350.3 nA/mM and high selectivity against representative plant sap interferents. The device further demonstrated stable operational reproducibility during continuous measurements and prolonged storage conditions. Using a three-electrode SI-MNE configuration, continuous glucose monitoring in living tomato plants successfully captured reproducible diurnal glucose fluctuations under natural light-dark cycles for 7 consecutive days without observable signal degradation or severe tissue damage. The proposed SI-MNE establishes a mechanically robust and electrochemically reliable biointerface for continuous metabolic monitoring in plants and provides a broadly applicable strategy for long-term in situ plant biosensing. - Source: PubMed
Publication date: 2026/09/23
Hwang ChuljinKim Ju HyeonJo Hang ChanKim Dae Yu - Spherical boron nitride (BN) particles offer geometric advantages for three-dimensional thermal network formation, yet their large filler-matrix interfacial area amplifies interfacial thermal resistance, limiting practical thermal conductivity enhancement. To address this limitation, an inverse core-shell hybrid filler strategy was developed in which graphene oxide-coated BN (GO-BN) and partially reduced graphene oxide-coated BN (prGO-BN) serve complementary and distinct functional roles within an epoxy matrix. The prGO-derived shell acts as a phonon-bridging interlayer that reduces interfacial thermal resistance and promotes thermally conductive pathway formation, while the oxygen-rich GO shell of GO-BN improves filler dispersibility and suppresses electrical percolation among prGO-BN particles at high filler loadings. Comprehensive characterization confirmed that the two fillers differ exclusively in the chemical state and surface polarity of their outer shells, enabling systematic decoupling of thermal and electrical transport pathways within the composite. The optimized GO-BN/prGO-BN hybrid composite simultaneously achieves a thermal conductivity of 6.25 W m K and a volume resistivity of 1.3 × 10 Ω cm at 60 wt.% total filler loading, demonstrating that precise interfacial engineering of graphene-derived shell chemistry constitutes an effective strategy for next-generation electrically insulating thermal interface materials. - Source: PubMed
Publication date: 2026/09/23
Yang YunhoJeong TaeyoungYoon Chang-MinKim Myeongjin