SOX6 Poly
- Known as:
- SOX6 Poly
- Catalog number:
- 28117
- Product Quantity:
- 100ug
- Category:
- -
- Supplier:
- QED
- Gene target:
- SOX6 Poly
Related genes to: SOX6 Poly
- Gene:
- SOX6 NIH gene
- Name:
- SRY-box 6
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-15
- Date modifiied:
- 2015-11-23
Related products to: SOX6 Poly
Related articles to: SOX6 Poly
- India possesses a rich diversity of indigenous cattle that are well adapted to varied agro-climatic regions. These populations exhibit remarkable variation in stature (height at withers), ranging from short-statured types such as Vechur, Punganur, Malnad Gidda, and Khariar to tall and heavy breeds like Kankrej, Ongole and other milch breeds (Sahiwal, Gir, etc.). The short-statured breeds offer potential advantages in feed efficiency, disease resilience, and cultural value besides being economical to maintain. However, their genetic basis for stature remains underexplored. This study leverages whole-genome resequencing (WGS) data on short-statured (n = 19) and tall (Kankrej as representative; n = 19) Indian cattle to delineate the copy number variation (CNV) landscape and selection signatures underpinning stature divergence. Post-quality control, CNVs were detected from duplicate-marked bam files using CNVnator with read-depth methodology, filtered (q0 < 0.5, p < 0.01, size 1 kb-5 Mb), and concatenated into CNV regions (CNVRs). Selection signatures were identified using cross population extended haplotype homozygosity (XP-EHH) methodology for inter-population comparison of short-statured cattle with tall cohort. Genes harboured under CNVRs and sweep windows were annotated using GALLO, with functional mining from literature databases. In short-statured cattle, 41,913 CNVs were concatenated into 10,075 CNVRs, with 8.01% genomic coverage. A total of 25 genes were found to be common across two analyses i.e., unique (non-overlapping) CN regions in 70% short-statured individuals and scan of selection signature. Key genes across the analyses included IGF1R (cell proliferation), FGFR3 (skeletal growth), SOX6 (body size), EXT2/LGR4 (bone density), PRKCD (developmental regulation), ADAMTSL2 (extracellular matrix integrity), SLC25A6 (glucose metabolism), and SDHA (energy supply). Unique non-overlapping copy number regions (e.g., 78 regions found in 100% of dwarf individuals) harbored several genes, including ARL13B (osteogenesis), AXIN2 (bone remodeling), CCND2 (myogenesis), and TNNT1 (muscle contraction). This comprehensive CNV map and scan for signatures of selection unveil stature-associated genomic variants, informing conservation strategies for threatened short-statured breeds by enhancing their socio-economic value through targeted breeding. The findings underscore CNVs as pivotal drivers of phenotypic diversity in cattle populations, with implications for livestock genomics and sustainable agriculture. - Source: PubMed
Publication date: 2026/06/08
Ahmad Sheikh FirdousAarif OvaisHassan Mir MehrozChand RoshniGangwar MunishT Sarath KumarKumar Amit - Adolescent idiopathic scoliosis (AIS), the spontaneous development of a lateral spine curvature during puberty, is the most common pediatric spine disorder, affecting ∼3% of children worldwide. As the underlying etiology remains unclear, AIS is treated purely symptomatically, initially by bracing and ultimately by highly invasive, costly surgeries. Genome-wide association studies (GWAS) have identified numerous risk loci in non-coding genomic regions, making it difficult to link them to a biological function. To address this, we performed a multi-tissue investigation to connect genetic risk to tissue-specific molecular pathology. We conducted RNA sequencing on the primary tissues implicated in AIS, paraspinal muscle and spinal cartilage, from patients and unaffected controls. In paraspinal muscle, we identified differentially expressed genes (DEGs) enriched for pathways related to muscle structure, myogenesis, and metabolism. Key upregulated genes include the transcription factor EGR1 and structural components such as MYH1. In spinal cartilage, we found enrichment of genes related to TGFβ and FoxO signaling, as well as metabolic pathways. Notably, genes crucial for chondrocyte differentiation (e.g. SOX5 and SOX6) were significantly downregulated. We then examined genes at known GWAS loci and found that several risk-associated genes were differentially expressed in one or both tissues. To investigate the function of non-coding variants at these loci, we identified and validated several enhancer elements harboring AIS risk SNPs at the BCL2, ADGRG6, BNC2, and FTO loci. We reveal distinct pathological signatures in muscle and cartilage and lay the foundation for connecting non-coding genetic risk to the dysregulation of key developmental and structural pathways. - Source: PubMed
Publication date: 2026/06/04
Ramkhalawan DariusParrales PaolaKoesterich JustinMontoya-Vazquez GloriaCuna CarlosKreimer AnatMcQuerry JessicaIhnow StephanieMakki Nadja - Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation-mediated infection assay and histological and immunohistochemical approaches. The findings reveal that Atlantic salmon with a systemic ISAV infection displayed ISAV antigen accumulation in specific ocular tissues and significant ocular morphological changes that could compromise visual acuity. Immunohistochemical analyses showed that ISAV-related ocular pathological changes correlate with changes in expression levels and/or spatial localizations of IgM, Sox6, Sox9, collagen type 1, Gata1, and CD10 in specific compartments of the eye. The cornea is likely one of the first ocular tissues to be exposed to the cohabitation-mediated ISAV infection. The ISAV-infected Atlantic salmon showed corneal dysplasia, which correlated with increased corneal stromal ISAV antigen expression, dysregulated IgM, Sox6, and collagen type 1 expression, and an induction of Sox9 expression at the corneal surface. The choroid rete mirabile of ISAV-infected eyes showed a decreased complement of erythrocytes, consistent with anaemia, while Gata1 expression, a key mediator of erythropoiesis, was upregulated compared to non-infected eyes, suggesting a potential erythropoietic compensatory response. These findings provide a basis for further study of ISAV-mediated ocular pathological changes and new insight into the pathogenesis of orthomyxoviruses in the eye. - Source: PubMed
Publication date: 2026/06/01
Mahon EmilyKwabiah Rebecca RParadis HélèneSoto-Dávila Manuel ADuglas SatheesGurung Raja RamParamanathan ThurkaVasquez IgnacioAl-Badoosh ShamsLaw JohnSantander JavierFast Mark DGendron Robert L - Postpartum depression (PPD) is a common and serious mental disorder after childbirth, imposing a heavy burden on mothers, infants, and families. Abnormalities in the tryptophan-kynurenine (TRP-KYN) metabolic pathway are considered to be involved in its pathogenesis, but the role of quinolinic acid phosphoribosyltransferase (QPRT), a key downstream enzyme in this pathway, remains unclear. This study aims to explore the association between PPD in women undergoing cesarean section and gene polymorphisms, as well as other risk factors for PPD. - Source: PubMed
Zhao ShanshanLin GuoxinLi ZiyuanPing AnqiWang SaiyingDuan Kaiming - - Source: PubMed
Publication date: 2026/04/21
Liu ZhuohuiLiao XiufuZhao HexiangRuan BiaoJia FengfengLong Ruiqing