NADH Oxidase Landscape (Large Format PEP)
- Known as:
- NADH Oxidase Landscape (Large Format PEP)
- Catalog number:
- AB000502
- Product Quantity:
- 1pk
- Category:
- -
- Supplier:
- Array Bridge
- Gene target:
- NADH Oxidase Landscape (Large Format PEP)
Ask about this productRelated genes to: NADH Oxidase Landscape (Large Format PEP)
- Gene:
- ANPEP NIH gene
- Name:
- alanyl aminopeptidase, membrane
- Previous symbol:
- CD13, PEPN
- Synonyms:
- LAP1, gp150, p150
- Chromosome:
- 15q26.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-02-28
- Date modifiied:
- 2016-10-05
- Gene:
- APLN NIH gene
- Name:
- apelin
- Previous symbol:
- -
- Synonyms:
- apelin, XNPEP2
- Chromosome:
- Xq26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-01
- Date modifiied:
- 2016-10-05
- Gene:
- C17orf80 NIH gene
- Name:
- chromosome 17 open reading frame 80
- Previous symbol:
- -
- Synonyms:
- HLC-8, MIG3, FLJ20721, SPEP1
- Chromosome:
- 17q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-13
- Date modifiied:
- 2016-09-30
- Gene:
- CNDP2 NIH gene
- Name:
- carnosine dipeptidase 2
- Previous symbol:
- PEPA
- Synonyms:
- FLJ10830, CN2, HsT2298, CPGL
- Chromosome:
- 18q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-14
- Date modifiied:
- 2017-03-23
- Gene:
- DNPEP NIH gene
- Name:
- aspartyl aminopeptidase
- Previous symbol:
- -
- Synonyms:
- DAP, ASPEP
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-22
- Date modifiied:
- 2016-10-05
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- Damage to the development of porcine gametes and embryos caused by high temperatures (HT) is one of the main reasons for the decline in the economic benefits of the livestock industry. Zygotic genome activation (ZGA) marks the beginning of gene expression programs in mammalian pre-implantation embryos. In pigs, ZGA occurs at the 4-cell (4 C) stage, indicating that correct gene expression at this stage plays an important regulatory role in embryonic development. However, the effect of the HT environment on early porcine embryonic development and the RNA expression profile of ZGA remain unclear. In this study, we compared the RNA transcription patterns of porcine 4 C embryos under normal and HT conditions using RNA-seq and identified 326 differentially expressed genes (DEGs). These changes were mainly related to DNA polymerase activity, DNA replication, and nucleotidyltransferase activity. In addition, entries for reverse transcription and endonuclease activity were enriched, indicating that ZGA interfered under HT conditions. Further comparison of the experimental results with the porcine ZGA gene revealed 39 ZGA genes among the DEGs. KEGG and GSEA analysis showed that the oxidative phosphorylation pathway was significantly enriched and signaling pathways related to energy metabolism were significantly downregulated. We also found that NDUFA6 and CDKN1A were located at the center of the protein-protein interaction network diagram of the DEGs. In summary, HT conditions affect mitochondrial function and oxidative phosphorylation levels, and lead to changes in the expression pattern of ZGA in early porcine embryos, with its hub genes NDUFA6 and CDKN1A. - Source: PubMed
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