NADH Oxidase Connect (Small Format PEP)
- Known as:
- NADH Oxidase Connect (Small Format PEP)
- Catalog number:
- AB000402
- Product Quantity:
- 1pk
- Category:
- -
- Supplier:
- Array Bridge
- Gene target:
- NADH Oxidase Connect (Small Format PEP)
Ask about this productRelated genes to: NADH Oxidase Connect (Small Format PEP)
- Gene:
- ANPEP NIH gene
- Name:
- alanyl aminopeptidase, membrane
- Previous symbol:
- CD13, PEPN
- Synonyms:
- LAP1, gp150, p150
- Chromosome:
- 15q26.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-02-28
- Date modifiied:
- 2016-10-05
- Gene:
- APLN NIH gene
- Name:
- apelin
- Previous symbol:
- -
- Synonyms:
- apelin, XNPEP2
- Chromosome:
- Xq26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-01
- Date modifiied:
- 2016-10-05
- Gene:
- C17orf80 NIH gene
- Name:
- chromosome 17 open reading frame 80
- Previous symbol:
- -
- Synonyms:
- HLC-8, MIG3, FLJ20721, SPEP1
- Chromosome:
- 17q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-13
- Date modifiied:
- 2016-09-30
- Gene:
- CNDP2 NIH gene
- Name:
- carnosine dipeptidase 2
- Previous symbol:
- PEPA
- Synonyms:
- FLJ10830, CN2, HsT2298, CPGL
- Chromosome:
- 18q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-14
- Date modifiied:
- 2017-03-23
- Gene:
- DNPEP NIH gene
- Name:
- aspartyl aminopeptidase
- Previous symbol:
- -
- Synonyms:
- DAP, ASPEP
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-22
- Date modifiied:
- 2016-10-05
Related products to: NADH Oxidase Connect (Small Format PEP)
(E)_2_Hexen_1_ol formate trans_2_Hexenyl format1 x 5ml Adapter, Small Bore For Rotor F-35-6-301-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 350 plus slides (small size1-step Polymer HISTO-STAT Peroxidase (HRP) Multivalent AEC kit for IHC staining of Mouse, Rabbit & Rat primary antibodies, 350 plus slides (small size1-step Polymer HISTO-STAT Peroxidase (HRP) Multivalent DAB kit for IHC staining of Mouse, Rabbit & Rat primary antibodies, 350 plus slides (small size1.0 mm
10 wells;
small cassette; 10 x 8 cm; 3 and 6.5%1.0 mm
10 wells;
small cassette; 10 x 8 cm; 3%1.0 mm
10 wells;
small cassette; 10 x 8 cm; 4%1.0 mm
15 wells;
small cassette; 10 x 8 cm, 10% TAE, 40_1000 bp1.0 mm
15 wells;
small cassette; 10 x 8 cm, 10% TBE, 40_1000 bp1.0 mm
15 wells;
small cassette; 10 x 8 cm, 10% Tris, 30_200 kda1.0 mm
15 wells;
small cassette; 10 x 8 cm, 10% Tris, 30_200 kda1.0 mm
15 wells;
small cassette; 10 x 8 cm, 10_20% Tris, 5_150 kda1.0 mm
15 wells;
small cassette; 10 x 8 cm, 10_20% Tris, 5_150 kda1.0 mm
15 wells;
small cassette; 10 x 8 cm, 12% Tris, 20_200 kda Related articles to: NADH Oxidase Connect (Small Format PEP)
- Damage to the development of porcine gametes and embryos caused by high temperatures (HT) is one of the main reasons for the decline in the economic benefits of the livestock industry. Zygotic genome activation (ZGA) marks the beginning of gene expression programs in mammalian pre-implantation embryos. In pigs, ZGA occurs at the 4-cell (4 C) stage, indicating that correct gene expression at this stage plays an important regulatory role in embryonic development. However, the effect of the HT environment on early porcine embryonic development and the RNA expression profile of ZGA remain unclear. In this study, we compared the RNA transcription patterns of porcine 4 C embryos under normal and HT conditions using RNA-seq and identified 326 differentially expressed genes (DEGs). These changes were mainly related to DNA polymerase activity, DNA replication, and nucleotidyltransferase activity. In addition, entries for reverse transcription and endonuclease activity were enriched, indicating that ZGA interfered under HT conditions. Further comparison of the experimental results with the porcine ZGA gene revealed 39 ZGA genes among the DEGs. KEGG and GSEA analysis showed that the oxidative phosphorylation pathway was significantly enriched and signaling pathways related to energy metabolism were significantly downregulated. We also found that NDUFA6 and CDKN1A were located at the center of the protein-protein interaction network diagram of the DEGs. In summary, HT conditions affect mitochondrial function and oxidative phosphorylation levels, and lead to changes in the expression pattern of ZGA in early porcine embryos, with its hub genes NDUFA6 and CDKN1A. - Source: PubMed
Publication date: 2024/09/19
Sun Ming-HongZhan Cheng-LinLi Xiao-HanLee Song-HeeCui Xiang-Shun - Identifying effective pharmacological interventions to prevent the progressive enlargement and rupture of aortic aneurysms (AAs) is critical. Previous studies have suggested links between metformin use and a decreased incidence of AAs. In this study, we employed Mendelian randomization (MR) to investigate causal effects of metformin's targets on AA risk and to explore the underlying mechanisms underlying these effects. - Source: PubMed
Publication date: 2024/03/05
Liu JingwenXu MingyuanNi BinZhang ZhaohuaGao XixiZhang DingkaiYang LiangYe ZhidongWen JianyanLiu Peng - Breast cancer represents the predominant malignant neoplasm in women, posing significant threats to both life and health. N6-methyladenosine (m6A) methylation, the most prevalent RNA modification, plays a crucial role in cancer development. This study aims to delineate the prognostic implications of m6A-associated long non-coding RNAs (m6AlncRNAs) and identify potential m6AlncRNA candidates as novel therapeutic targets for breast cancer. Through univariate Cox, Least Absolute Shrinkage and Selection Operator and multiple Cox regression analysis, m6AlncRNA was analyzed and a risk-prognosis model was constructed. Kaplan-Meier analysis, principal component analysis and nomogram were used to evaluate the risk model. Finally, we screened candidate lncRNAs and validated them in breast cancer cell lines. m6AlncRNAs were stratified into three subtypes, and their associations with survival outcomes and immune infiltrating capacities were systematically analyzed. Subsequently, breast cancer patients were stratified into high and low-risk groups based on median risk scores, revealing distinct clinical characteristics, tumor immunoinvasive profiles, tumor mutation burden, and survival probabilities. Additionally, a prognostic model was established, highlighting three promising candidate lncRNAs: ECE1-AS1, NDUFA6-DT, and COL4A2-AS1. This study investigated the prognostic implications of m6A-associated long non-coding RNAs (m6AlncRNAs) and developed a prognostic risk model to identify three potential m6AlncRNA candidates. These findings provide valuable insights into the potential application of these m6AlncRNAs in guiding immunotherapeutic strategies for breast cancer. - Source: PubMed
Publication date: 2024/07/23
Gu YunXu MinWu WangfeiMa ZhifangLiu Weiguang - Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated . FZHYR inhibited pulmonary inflammation and fibrosis and M2 polarization of macrophages in bleomycin-induced pulmonary fibrosis (BPF) of rat model. Differentially expressed genes were screened by high-throughput mRNA sequencing and GSEA showed that oxidative phosphorylation (OXPHOS) was correlated with BPF. FZHYR inhibited expressions of and in lung tissues of BPF rats. These findings suggest that OXPHOS pathway serves as a possible target for pulmonary fibrosis therapy by FZHYR. - Source: PubMed
Publication date: 2024/07/03
Yuan Xing-HuaZhang Su-FangHang YuShen Yan-HuaZhang Shan-FangHuang Wei-LingHuang Jing-YiQian Ye-ChangZhang Xiu-LianLi Qiu-HongLi Li - Gliomas are the most prevalent primary malignant tumors affecting the brain, with high recurrence and mortality rates. Accurate diagnoses and effective treatment challenges persist, emphasizing the need for identifying new biomarkers to guide clinical decisions. Long noncoding RNAs (lncRNAs) hold potential as diagnostic and therapeutic biomarkers in cancer. However, only a limited subset of lncRNAs in gliomas have been explored. Therefore, this study aims to identify lncRNA signatures applicable to patients with gliomas across all grades and explore their clinical significance and potential biological mechanisms. Data used in this study were obtained from TCGA, CGGA, and GEO datasets to identify key lncRNA signatures in gliomas through differential and survival analyses and machine learning algorithms. We examined their associations with the clinical characteristics, gene mutations, diagnosis, and prognosis of gliomas. Functional enrichment analysis was employed to elucidate the potential biological mechanisms associated with these significant lncRNA signatures. We explored competing endogenous RNA (ceRNA) regulatory networks. We found that NDUFA6-DT emerged as a significant lncRNA signature in gliomas, with reduced NDUFA6-DT expression associated with a worse prognosis in gliomas. Nomogram analysis incorporating NDUFA6-DT expression levels exhibited excellent prognostic and predictive capabilities. Functional annotation suggested that NDUFA6-DT might influence immunological responses and synaptic transmission, potentially modifying glioma initiation and progression. The associated ceRNA network revealed the possible presence of the NDUFA6-DT-miR-455-3p-YWHAH/YWHAG axis in low-grade glioma (LGG) and glioblastoma multiforme (GBM), regulating the PI3K-AKT signaling pathway and influencing glioma cell survival and apoptosis. We believe that NDUFA6-DT is a novel lncRNA linked to glioma diagnosis and prognosis, potentially becoming a pivotal biomarker for glioma. - Source: PubMed
Publication date: 2024/04/11
Huang RuitingKong YingLuo ZhiqingLi Quhuan