mouse monoclonal antibody mix for arthritis induction in mice Mouse collagen II CAIA
- Known as:
- mouse mab (anti-) mix arthritis induction mice Mouse collagen II CAIA
- Catalog number:
- 50mg
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- ModiQuest
- Gene target:
- mouse monoclonal antibody mix for arthritis induction mice Mouse collagen CAIA
Related genes to: mouse monoclonal antibody mix for arthritis induction in mice Mouse collagen II CAIA
- Gene:
- MICE NIH gene
- Name:
- MHC class I polypeptide-related sequence E (pseudogene)
- Previous symbol:
- -
- Synonyms:
- dJ377H14.7, PERB11.5
- Chromosome:
- 6p22.1
- Locus Type:
- pseudogene
- Date approved:
- 1994-09-07
- Date modifiied:
- 2016-10-05
- Gene:
- TYR NIH gene
- Name:
- tyrosinase
- Previous symbol:
- -
- Synonyms:
- OCAIA, OCA1A, OCA1
- Chromosome:
- 11q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-16
- Date modifiied:
- 2015-08-24
Related products to: mouse monoclonal antibody mix for arthritis induction in mice Mouse collagen II CAIA
Related articles to: mouse monoclonal antibody mix for arthritis induction in mice Mouse collagen II CAIA
- The structural features and antioxidant activities of whey protein hydrolysates (WPHs) were investigated in this study. The secondary structure, fluorescence spectra and molecular weight distribution of WPHs changed with different hydrolysis time and strains. Tricine-SDS-PAGE results presented that some large proteins were hydrolyzed into small peptides (≤15kD). Compared with natural whey protein, the contents of free amino acids (including Tyr, Lys, etc.) in WPHs were increased. In addition, WPHs were not only with excellent scavenging ability to DPPH and hydroxyl radicals, but also could enhance the cell viability, decline ROS level and restore MMP of RAW264.7 cells induced by LPS. Three peptides were synthesized according to the identified results of BIOPEP-UWM database and exhibited high antioxidant activity in vitro and LPS-induced RAW264.7 cells. This study identifies the structural features of WPHs and explore their antioxidant activities and these results will have crucial theoretical significance for commercial development of WPHs. - Source: PubMed
Publication date: 2025/04/17
Duan CuicuiHu ShunanWu ChengZhang YiMa LinLi XiaoleiMa FuminLi Dan - Targeted alpha therapy (TAT) has shown high promise for the effective treatment of advanced stage cancers. Of the proposed radionuclides for TAT, Thorium-227 represents an interesting candidate given its relatively long half-life, 18.7 days, and the cascade of short-lived, high-potency, alpha-emitting daughter progeny in its decay scheme. However, to date few chelators exist which can effectively and stably bind [Th]Th at molar activities high enough for TAT. To address this challenge, this study investigated various chelating ligands for coordination of [Th]Th. HnoneunpaX was identified as a promising chelator, demonstrating radiolabeling with [Th]Th at concentrations of 10 M (A = 272 kBq/nmol). The coordination characteristics of [Th(noneunpaX)] have been investigated through H NMR spectroscopy, mass spectrometry, and DFT calculations. In this study, we also investigate for the first time the pairing of Th-227 with a peptide-based bioconjugate and evaluate the biodistribution characteristics. [Th]Th-nonenupaX-Ahx-Tyr-TATE was prepared under mild conditions (ambient temperature, 30 min) and evaluated in NRG mice bearing AR42J xenografts as a model for pancreatic neuroendocrine tumors. The Th-labeled radiopeptide showed high uptake in tumors (25.8±6.2 %IA/g at 3 h p.i.) and low uptake in non-targeted organs. Although some release of Th-227 was noted in serum stability studies this was not observed . This ligand architecture serves as an interesting framework for future optimization, which will involve improvements to the overall stability by enhancing the rigidity of the backbone and assessing other pendent donor groups with a stronger affinity toward [Th]Th. Overall, this study demonstrated for the first time the viability of using peptide-based targeting to effectively deliver Th-227 to tumor sites. - Source: PubMed
Publication date: 2025/05/10
Wharton LukeMcNeil Scott WMeeres HarrisonZhang DiduoIngham AidanMerkens HelenOsooly MaryamRodríguez-Rodríguez CristinaBénard FrançoisYang Hua - Skin aging is a complex process driven by intrinsic genetic factors and extrinsic environmental influences. In this study, sequestosome1 (SQSTM1/p62) was identified as a key regulator of senescence, the senescence-associated secretory phenotype (SASP), and skin aging. Notably, p62 expression is reduced in senescent cells and aging skin of both humans and mice. The depletion of p62 in the epidermis was found to be positively associated with accelerated aging and the initiation of SASP. Mechanistically, p62 inhibits the accumulation of ubiquitin-specific protease 7 (USP7) during senescence induction by orchestrating its degradation through specific binding interactions. In particular, the Tyr-67 residue within the PB1 domain or Gln-418 within the UBA domain of p62 forms a hydrogen bond with Ala-993 in the Ubl5 domain of USP7. Mutations in either Tyr-67 or Gln-418 of p62, or Ala-993 of USP7, resulted in the induction of cellular senescence, highlighting the critical role of these molecular interactions in the regulation of aging processes. - Source: PubMed
Publication date: 2025/05/08
Chen LiuWang XiaopingWang YuchenYao QingxinLiu YunyaoZhu YongchengHuang HeYang HedanYang YinHe YuanQiang Lei - Herpesviruses encode conserved protein kinases (CHPKs) that target cellular cyclin-dependent kinase (CDK) phosphorylation sites; thus, they are termed viral CDK-like kinases. Tyrosine 15 in the GxGxxG motifs of CDK1 and CDK2, whose phosphorylation down-regulates their catalytic activities, is conserved in the corresponding motifs of CHPKs. We found that CHPK UL13, the corresponding Tyr-162 in herpes simplex virus 2 (HSV-2), was phosphorylated in HSV-2-infected cells. Mutational analyses of HSV-2 UL13 Tyr-162 suggested that phosphorylation of UL13 Tyr-162 reduced the phosphorylation of all UL13 substrates tested in HSV-2-infected cells. These findings suggested that HSV-2 UL13 mimicked the regulatory mechanism of CDKs and that this CHPK has regulatory and functional mimicry with CDKs. Furthermore, phosphorylation of HSV-2 UL13 Tyr-162 was suggested to be required for the downregulation of viral replication and pathogenicity, specifically in the brains of mice, and for efficient viral recurrence in guinea pigs. These findings highlight the dual impact of the regulatory mimicry of CDKs by CHPK on the fine-tuned regulation of lytic and latent HSV-2 infections in vivo. - Source: PubMed
Publication date: 2025/04/16
Koyanagi NaotoHengphasatporn KowitKato AkihisaNobe MoekaTakeshima KosukeMaruzuru YuheiMaenaka KatsumiShigeta YasuteruKawaguchi Yasushi - The aesthetic issues caused by pigmentation are increasing people's demand for skin whitening. Considering its long-term use, it is very important for searching safe and effective agents. Pomegranate flower, a kind of traditional Chinese medicine, has shown promising anti-inflammatory, antioxidant, and antidiabetic properties, but its potential skin-lightening effects have not been well explored. - Source: PubMed
Shu PengXu NannanAbudukelimu NuermaimaitiAiziti ParidaZang DengZhao JiangyuWang Yuan