MAPK10 (JNK3), Active Human Recombinant Protein
- Known as:
- MAPK10 (JNK3), Active Human Recombinant Protein
- Catalog number:
- 40092
- Product Quantity:
- 10 µg
- Category:
- -
- Supplier:
- Biotech support group
- Gene target:
- MAPK10 (JNK3) Active Human Recombinant Protein
Related genes to: MAPK10 (JNK3), Active Human Recombinant Protein
- Gene:
- MAPK10 NIH gene
- Name:
- mitogen-activated protein kinase 10
- Previous symbol:
- PRKM10
- Synonyms:
- JNK3, p493F12, p54bSAPK
- Chromosome:
- 4q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-28
- Date modifiied:
- 2016-10-05
Related products to: MAPK10 (JNK3), Active Human Recombinant Protein
Related articles to: MAPK10 (JNK3), Active Human Recombinant Protein
- Ventral midbrain dopaminergic neurons are a key cell type for schizophrenia pathophysiology but information about cell type-specific genomic dysregulation in diseased brains is missing. We generated a unique midbrain functional genomics resource with 97 RNA-seq and 34 Hi-C chromosomal contact libraries for Nurr1 + /NeuN+ dopaminergic and their surrounding Nurr1-/NeuN- nuclei, collected from donors diagnosed with schizophrenia (SCZ), bipolar disorder (BD) and compared to neurotypical controls. Among the 954 dopamine neuron genes specifically dysregulated in SCZ, 331 were downregulated, with selective enrichment for risk-associated synaptic plasticity and neuronal connectivity pathways and embedded within dopamine neuron-specific topologically associated chromosomal domains (TAD). Transcript-resolved analysis revealed 2,350 transcripts with altered expression in SCZ dopamine neurons, affecting key susceptibility genes such as the FOXP1, MAPK10, PCM1 and NRXN1. Therefore, genomic dysregulation in the ventral midbrain of subjects diagnosed with SCZ selectively affects dopaminergic neurons, and includes a unilateral association of genetic risk with down-, but not upregulated transcription at the sites of highly organized chromosomal domains harboring neuron-specific genes with complex transcriptional architectures. - Source: PubMed
Publication date: 2026/04/06
Singh SwadhaIskhakova MarinaLambert Tova YValada AditiShokrian NedaEvans VivianaBendl JaroslavAuluck Pavan KMarenco StefanoWang MinghuiZhang BinHoffman Gabriel EGirdhar KiranRoussos PanosAkbarian Schahram - Co-infection with avian leukemia and Pullorum Disease severely compromises poultry health, yet its pathogenic mechanisms remain unclear. We employed transcriptome sequencing to analyze gene expression changes and enriched pathways in kidney, spleen, and liver tissues of Chongqing Chengkou mountain chickens under single-infection (avian leukemia virus or Pullorum Disease) and co-infection conditions. Significant differences were observed in the number and pathways of differentially expressed genes between co-infected and single-infected groups. These genes were predominantly enriched in pathways involving extracellular matrix-receptor interactions, PPAR signaling, and calcium ion signaling. RT-qPCR validation confirmed significant upregulation of MAPK10 and SQLE, alongside downregulation of genes such as FOXG1. This study identifies multiple differentially expressed genes and pathways associated with immunity and tumorigenesis, providing crucial molecular insights into the regulatory mechanisms underlying avian leukemia and Pullorum Disease co-infection. - Source: PubMed
Publication date: 2026/03/18
Tan MinRan RongLiu ChengXie TaoZhang KeshanWang QiguiLan XiWang Haiwei - Three new racemic bianthrones, including two pairs of (±)-penithrones A () and B (), and a chlorinated derivative (±)-penithrone C (), along with their biogenetic precursors (-) were discovered from the culture extract of the mangrove-derived fungus LA032 using HSQC-based DeepSAT. The structural elucidation of these new compounds was achieved through comprehensive integration of NMR spectroscopy, high-resolution mass spectrometry (HRESIMS), and NMR calculations with CP3 analysis. Compounds and exhibited significant cytotoxic activity against HeLa, HCT116, and MCF-7 cancer cell lines, with IC values ranging from 5.09 ± 0.65 to 9.47 ± 0.22 μmol/L. In addition, network pharmacology analysis and molecular docking studies revealed Mitogen-Activated Protein Kinase 10 (MAPK10) as a potential target of for its anticancer effect. - Source: PubMed
Publication date: 2025/07/10
Huo RuiyunJi MinhuiLiu GaoranLiu Ling - Non-alcoholic fatty liver disease (NAFLD) represents a highly prevalent metabolic disorder; however, the functional role of mitogen-activated protein kinase 10 (MAPK10) in the initiation and progression of NAFLD remains incompletely understood. This study investigated MAPK10's role in NAFLD and its regulatory mechanisms. - Source: PubMed
Liu JingLiu ChuangXiao HuanzhiCao PengZhou Sufang - Understanding how signaling networks differ across molecular subgroups of Parkinson's disease (PD) is essential for gaining further mechanistic insights and advancing therapeutic development for the disease. This study introduces an integrative, stratified computational framework to characterize subgroup-specific changes in kinase-transcription factors' (TFs) interactions using transcriptomic profiles. - Source: PubMed
Publication date: 2026/02/17
Zhou XiaoyanParisi LucaLiu SicenCheng ZiqiLiang HanwenYouseffi MansourJavid FaridehMa Renfei