Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), CLMF, CLMF2, IL-12B, NKSF, NKSF2, rHuman Interleukin-12p40
- Known as:
- Interleukin 12B (natural killer cellular stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), CLMF, CLMF2, Interleukin-12B, NKSF, NKSF2, rHuman Interleukin-12p40
- Catalog number:
- RF0031-5
- Product Quantity:
- 5ug
- Category:
- -
- Supplier:
- Agren
- Gene target:
- Interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturation p40) CLMF CLMF2 IL-12B NKSF NKSF2 rHuman Interleukin-12p40
Related genes to: Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), CLMF, CLMF2, IL-12B, NKSF, NKSF2, rHuman Interleukin-12p40
- Gene:
- ARMH1 NIH gene
- Name:
- armadillo like helical domain containing 1
- Previous symbol:
- NCRNA00082, C1orf228
- Synonyms:
- MGC33556, p40
- Chromosome:
- 1p34.1
- Locus Type:
- gene with protein product
- Date approved:
- 2008-09-02
- Date modifiied:
- 2019-02-21
- Gene:
- ARPC1B NIH gene
- Name:
- actin related protein 2/3 complex subunit 1B
- Previous symbol:
- -
- Synonyms:
- ARC41, p40-ARC, p41-ARC
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-06
- Date modifiied:
- 2019-04-23
- Gene:
- CD7 NIH gene
- Name:
- CD7 molecule
- Previous symbol:
- -
- Synonyms:
- GP40, LEU-9, TP41, Tp40
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
- Gene:
- DNAJB1 NIH gene
- Name:
- DnaJ heat shock protein family (Hsp40) member B1
- Previous symbol:
- HSPF1
- Synonyms:
- Hsp40, Sis1, RSPH16B
- Chromosome:
- 19p13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-02
- Date modifiied:
- 2015-11-19
- Gene:
- EIF3H NIH gene
- Name:
- eukaryotic translation initiation factor 3 subunit H
- Previous symbol:
- EIF3S3
- Synonyms:
- eIF3-gamma, eIF3-p40, eIF3h
- Chromosome:
- 8q23.3-q24.11
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-26
- Date modifiied:
- 2018-02-13
Related products to: Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), CLMF, CLMF2, IL-12B, NKSF, NKSF2, rHuman Interleukin-12p40
Related articles to: Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), CLMF, CLMF2, IL-12B, NKSF, NKSF2, rHuman Interleukin-12p40
- Dysbiosis of gut microbiota is well established in coronavirus disease 2019 (COVID-19). While studies have attempted to establish a link between the gut commensal () and COVID-19, the findings have been inconsistent and sometimes controversial. The intestinal microbial abundance information of COVID-19 patients was acquired and analysed from GMrepo database. Subsequently, metabolites, target-genes, and metabolite-target relationships was extracted from GutMGene database. Lastly, coronascape module in Metascape database is used for gene annotation and enrichment analysis in various host cells and tissues after SARS-CoV-2 infection. The results indicated that, in comparison to healthy people, was significantly elevated in COVID-19 patients. This bacterium was found to be associated with heightened expression of IL-10, TLR2, TLR4, CLGN, CLDN4, TJP2, and TJP3, while concurrently experiencing a reduction in the expression of IL-12A and IL-12B in humans. The regulatory genes of primarily enhance responses to viruses and cytokines, positively regulate cell migration, and control epithelial cell proliferation. Our study revealed a significant increase in the gut commensal in COVID-19 patients. This bacterium can modulate host immune responses and may also serve as a probiotic with antiviral properties. - Source: PubMed
Publication date: 2025/05/18
Dai Zhi-MingXu Meng-LuZhang Qing-QingZhu BoWu Jun-ZheLiu QiLi YingLi Hong-Bao - Little is known about the in-vivo dynamics of biofilms associated with medical-device infections and their interplay with systemic inflammation, local immune responses, and tissue healing processes. There may be an opportunity to tailor therapeutic strategies to target these dynamics to improve treatment outcomes. We investigated immune responses to a methicillin-susceptible (ATCC 12600) and a multi-drug resistant (L1101) S. aureus strain using a rat subcutaneous implant model, analyzing local and systemic inflammation through 19 gene expressions over 21 days. Our goals were to identify differences in the immune response due to infection and also with respect to the two strains. We observed that systemic inflammation, indicated by α-2-macroglobulin, was elevated in the initial stages (up to day 7). Local inflammatory cytokine levels (IL-6, TNF-α, IL-6, TNF-α, IL-1β, IL10, IL-17, IL12a, IL12b, IFNG) varied by strain, typically higher against the clinical strain. Infections generally hindered early macrophage (MCSF1) and T-cell (CD4, CD5, CD6, CD8A) recruitment, particularly in cases involving the clinical strain. Conversely, a better healing response was observed in the infection of the more susceptible ATCC 12600 strain (VEGF, CXCR1, CXCR2, MMP-1, MMP-3, MMP-13). These results are crucial for understanding immune responses to such infections, guiding therapeutic strategies. - Source: PubMed
Publication date: 2025/04/17
Fan YingfangSekar AmitaMcCanne MadelineYuh JeanKannambadi Devika DuttaLekkala SashankMuratoglu Orhun KOral Ebru - Suppression within the tumor microenvironment (TME) hampered natural killer (NK) cells and their role in cancer immunotherapy. This study explores how interleukin (IL) signaling (IL-12A, IL-12B, IL-15, IL-18) and interferon gamma (IFNG or IFN-γ) interact with microRNAs to regulate NK cell function in cancer. - Source: PubMed
Zabeti Touchaei ArefehVahidi SogandSamadani Ali Akbar - Interleukin-12 (IL12) plays a crucial role in immune regulation and inflammation and is critical in developing colorectal cancer (CRC). This study investigated the association between rs568408, rs2243115, and rs3212227 polymorphisms and CRC susceptibility in a Taiwanese population. - Source: PubMed
Yueh Te-ChengChen Ying-JingMong Mei-ChinKe Tao-WeiShih Hou-YuWang Yun-ChiChang Wen-ShinBau DA-TianTsai Chia-Wen - The presentation of posterior ocular tuberculosis (TB) varies greatly along with the need for immunomodulatory therapy to control inflammation. In this study, we explore the potential mechanisms and pathways for autoimmune-related inflammation in ocular TB using molecular mimicry-based mathematical modeling. - Source: PubMed
Publication date: 2024/12/30
Kutlutürk Karagöz IşılKaya MücahitKıvrak UlviyeMunk Marion R