Immunoglobulin G3 (IgG3), Human Plasma

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366 GBP
known as: Immunoglobulin G3 (IgG3), Human Plasma
Catalog number: genta-20007-G3-1P
Product Quantity: 100 ug
Supplier: ADI

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Gene target: immunoglobulin g3 igg3 plasma

More details: Immunoglobulin G3 (IgG3), Human Plasma


IgG antibodies are large molecules of about 150kilodalton made of four peptide chains. It contains two identical class γ heavy chains of about 50 kDa and two identical light chains of about 25 kDa, thus a tetrameric quaternary structure. The two heavy chains are linked to each other and to a light chain each by disulfide bonds. The resulting tetramer has two identical halves, which together form the Y-like shape. Each end of the fork contains an identicalantigen binding site. The various regions and domains of a typical IgG are depicted in the figure to the left. The Fc regions of IgGs bear a highly conserved N-glycosylation site. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and α-2,6-linked sialic acid residues.

The various regions and domains of a typical IgG


There are four IgG subclasses (IgG1, 2, 3, and 4) in humans, named in order of their abundance in serum (IgG1 being the most abundant).

Name Percent Crosses placenta easily Complement activator Binds to Fc receptor on phagocytic cells Half Life
IgG1 66% yes (1.47)* second-highest high affinity 21 days
IgG2 23% no (0.8)* third-highest extremely low affinity 21 days
IgG3 7% yes (1.17)* highest high affinity 7 days
IgG4 4% yes (1.15)* no intermediate affinity 21 days
* Quota cord/maternity concentrations blood. Based on data from a Japanese study on 228 mothers.

Related genes to: Immunoglobulin G3 (IgG3), Human Plasma

Symbol : G3 NIH gene
LocusTag : AURANDRAFT_61037
chromosome : Unknown
description : hypothetical protein
type of gene : protein-coding
Modification date : 2015-06-26

Related Pathways to: Immunoglobulin G3 (IgG3), Human Plasma

Gene about :IgG3
Pathway :Hs Allograft Rejection
Gene about :Plasma
Pathway :Rn Type II interferon signaling (IFNG)

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