human superoxide dismutase (SOD) ANTIBODIES Isotype IgG HOST SPECIES MOUSE
- Known as:
- H. sapiens superoxide dismutase (antioxidant enzyme) ANTIBODIES Isotype Immunoglobulin G HOST SPECIES MOUSE
- Catalog number:
- AB007
- Product Quantity:
- 1 mg
- Category:
- -
- Supplier:
- Polim
- Gene target:
- human superoxide dismutase (SOD) ANTIBODIES Isotype IgG HOST SPECIES MOUSE
Related genes to: human superoxide dismutase (SOD) ANTIBODIES Isotype IgG HOST SPECIES MOUSE
- Gene:
- BAG4 NIH gene
- Name:
- BCL2 associated athanogene 4
- Previous symbol:
- -
- Synonyms:
- SODD
- Chromosome:
- 8p11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-23
- Date modifiied:
- 2015-11-16
- Gene:
- CERNA2 NIH gene
- Name:
- competing endogenous lncRNA 2 for microRNA let-7b
- Previous symbol:
- -
- Synonyms:
- HOST2
- Chromosome:
- 10q23.1
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2017-04-27
- Date modifiied:
- 2017-07-14
- Gene:
- GCASPC NIH gene
- Name:
- gall bladder cancer associated suppressor of pyruvate carboxylase lncRNA
- Previous symbol:
- -
- Synonyms:
- TCONS_00011605, RP1-56L9.7-001, lnc-SOD2-1
- Chromosome:
- 6q25.3
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2016-08-04
- Date modifiied:
- 2017-03-22
- Gene:
- SOD3 NIH gene
- Name:
- superoxide dismutase 3
- Previous symbol:
- -
- Synonyms:
- EC-SOD
- Chromosome:
- 4p15.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-08
- Date modifiied:
- 2017-01-11
Related products to: human superoxide dismutase (SOD) ANTIBODIES Isotype IgG HOST SPECIES MOUSE
Related articles to: human superoxide dismutase (SOD) ANTIBODIES Isotype IgG HOST SPECIES MOUSE
- Gastric cancer (GC) is the second most common cancer-related mortality worldwide. Mounting evidence has demonstrated that dysregulated long noncoding RNAs (lncRNAs) are involved in the development of GC. LncRNA CERNA2 (competing endogenous lncRNA 2 for microRNA let-7b) was previously found to be upregulated and play an oncogenic role in hepatocellular carcinoma, osteosarcoma and breast cancer. However, the clinical significance and biological functions of CERNA2 in GC remain largely unknown. In this study, we found that CERNA2 expression was significantly increased in GC tissues and cell lines compared to adjacent non-cancerous tissues and normal gastric epithelial cells, respectively. High levels of CERNA2 were correlated with poor clinical parameters and an unfavorable prognosis of GC patients. Moreover, silencing CERNA2 expression effectively inhibited gastric cancer cell growth and induced cell apoptosis . Collectively, our results demonstrate that the up-regulation of CERNA2 is associated with malignant status and poor prognosis in patients with GC, and silencing CERNA2 expression inhibits gastric cancer cell growth and promotes cell apoptosis, suggesting CERNA2 could possibly be a promising diagnostic and treatment target for GC. - Source: PubMed
Publication date: 2018/12/01
Zhang JingjingHan XiaoJiang LeiHan ZhengquanWang Zian - Competing long noncoding RNA 2 (lncRNA 2) for microRNA let-7b (CERNA2) has emerged as an important regulator of tumorigenesis and cancer progression but the clinical value and regulatory function of CERNA2 is yet to be investigated in cervical carcinoma. In our study, we found the CERNA2 expression was obviously increased in cervical carcinoma tissues compared with adjacent normal cervical tissues. In addition, we observed that metastatic lymph nodes exhibited high levels of CERNA2 expression in contrast to primary cervical carcinoma tissues. Furthermore, high CERNA2 expression was associated with advanced clinical stage, lymph node metastasis, distant metastasis poor histological grade, and short overall survival in cervical carcinoma patients. Moreover, high CERNA2 expression acted as an independent unfavorable predictor for overall survival in cervical carcinoma patients. The cell migration and invasion assays in vitro suggested that knockdown of CERNA2 remarkably inhibited cell migration and invasion in cervical carcinoma. In conclusion, CERNA2 functions as an oncogenic lncRNA and may be as a potential therapeutic target in cervical carcinoma. - Source: PubMed
Publication date: 2019/02/21
Wang MinOuyang JianghuaLi Huali