Human E-Selectin _CD62E Protein Vector: HEK293
- Known as:
- Human E-Selectin _CD62E Protein Vector: HEK293
- Catalog number:
- 10086-H01H
- Product Quantity:
- 200μg
- Category:
- -
- Supplier:
- Provo
- Gene target:
- Human E-Selectin _CD62E Protein Vector: HEK293
Related genes to: Human E-Selectin _CD62E Protein Vector: HEK293
- Gene:
- SELE NIH gene
- Name:
- selectin E
- Previous symbol:
- ELAM1, ELAM
- Synonyms:
- ESEL, CD62E
- Chromosome:
- 1q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-08-25
Related products to: Human E-Selectin _CD62E Protein Vector: HEK293
Related articles to: Human E-Selectin _CD62E Protein Vector: HEK293
- Adolescents engaging in non-suicidal self-injury (NSSI) have been reported to show altered autonomic nervous system (ANS) function, indexed by decreased heart rate variability (HRV) and increased heart rate (HR). Preliminary findings in adolescents with borderline personality disorder (BPD) traits suggest, that improvement in ANS function is longitudinally associated with clinical improvement and that ANS activity predicts clinical outcome. Existing studies, however, are limited by small sample sizes and short follow-ups. N = 227 help-seeking adolescents with NSSI disorder who presented to an early intervention service for BPD participated in baseline and two yearly follow-up assessments (N = 81, N = 37), including comprehensive clinical diagnostics as well as recordings of resting electrocardiography. Associations between HR, HRV and clinical outcomes of interest (i.e., NSSI frequency, depression severity, number of BPD criteria and global functioning) were examined using structural equation modelling. While multivariate models showed no evidence for an association between HRV or HR and any of the clinical outcomes, there was evidence from models including cross-lagged effects, that HRV and HR predicted depression severity, number of BPD criteria (HRV only) and global functioning at subsequent assessments. This effect was not observed for NSSI frequency. Improvements in ANS function, indexed by an increase in HRV and decrease in HR, seem to precede the improvement of clinical symptoms in adolescents engaging in NSSI. Findings have clinical implications, suggesting that targeting ANS function as adjuvant treatment in adolescents engaging in NSSI is warranted, and routine monitoring of ANS function my guide clinical decision making. - Source: PubMed
Publication date: 2026/04/03
Koenig JulianMürner-Lavanchy Ines MHedinger NicoleSele SilvanoKaess Michael - Borderline Personality Disorder (BPD) is a severe mental illness, although its neurobiological underpinnings remain largely unknown. Structural Magnetic Resonance Imaging (sMRI) in adolescents can offer insights into potential biomarkers to help advance early detection and targeted intervention. However, previous findings have been mixed, possibly due to clinical heterogeneity that may be better captured using a dimensional approach to personality functioning (PF). The current study explored grey matter volume (GMV) in youth with varying degrees of BPD pathology, and associations with dimensional PF. N = 93 females (14-21 years) comprising three groups (full-threshold BPD, sub-threshold BPD, and healthy controls) underwent sMRI and were assessed with the Semi-Structured Interview for Personality Functioning DSM-5 (STiP-5.1). Groups were combined to reflect dimensional personality pathology. Multiple linear regression analyses were conducted to determine associations between the STiP-5.1 total score, and each of its four elements with: (i) total GMV, (ii) GMV in individual brain regions defined by the Desikan-Killiany-Tourville atlas, (iii) selected regions of interest (ROIs). All analyses were statistically non-significant: STiP-5.1 total and total GMV (p = 0.61); STiP-5.1 total and individual brain regions (all corrected p values ≥0.82); STiP-5.1 total and ROIs (all corrected p values ≥0.91). Results were non-significant for each element, and a validity check using BPD criteria confirmed STiP-5.1 findings. We found no evidence of an association of dimensionally assessed PF with GMV in young females. The pursuit of clinical research efforts on other potential biomarkers using dimensional conceptualisations of PF may represent worthy endeavours. - Source: PubMed
Publication date: 2026/03/28
Thomson MadelynCavelti MarialuisaMürner-Lavanchy InesSele SilvanoBürgi NiklasSeiffert NoraMoggi FranzWiest RolandKoenig JulianKaess Michael - Idiopathic Pulmonary Fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. BI-1015550 is an oral phosphodiesterase 4B (PDE4B) inhibitor that has shown anti-inflammatory and anti-fibrotic effects; the exact molecular target(s) and mechanism of action in fibrosis are unknown. BI-1015550, an orally available PDE4B inhibitor with a possible anti-fibrotic effect, whose molecular mechanism of action is unknown Methods: We adopt an integrative approach that combines network pharmacology for identifying putative targets, molecular docking, and Molecular Dynamics (MD) simulations to assess the binding, ML-based target prioritization. Predicted targets/pathways were verified by Western blotting and Immunohistochemistry (IHC). - Source: PubMed
Publication date: 2026/03/31
Jiao LiyuanZhang Caiqing - The current fragmented nature of research impedes a comprehensive understanding of the mechanistic pathways linking environmental exposure to emerging pollutants and their pathogenic outcomes. This study establishes a systematic framework linking bisphenol A (BPA) exposure to abdominal aortic aneurysm (AAA) development through integrated exposure modeling and cellular validation. Cross-species multi-omics analysis identified core targets, validated in vivo, revealing that BPA promotes AAA via TNF/NF-κB pathways, disrupting extracellular matrix remodeling, smooth muscle cell phenotype, inflammation, and senescence. Environmentally relevant BPA exposure altered key gene expression in vascular cells-Comp, Sdc2, and Sele in smooth muscle cells and macrophages; Comp, Ets1, Cd83, and Sele in endothelial cells; Comp, Lum, and Sele in fibroblasts-which also show prognostic potential. This work provides the first multiscale evidence chain from exposure to mechanism, improving BPA risk assessment and suggesting prevention targets for BPA-associated AAA. - Source: PubMed
Publication date: 2026/03/28
Zhang ShuliZhang FeilongLiu DandanWang XiaozengGuo YajingZhang NanDang ChungeWang Ruichen - Studies have shown that Helicobacter pylori (H. pylori) infection can induce chronic inflammation and immune responses in the gastric mucosa, potentially contributing to the development of lymphoma. To explore the association between H. pylori and Diffuse large B-cell lymphoma (DLBCL), the Mendelian randomization (MR) analysis was employed. Additionally, the CIBERSORT algorithm was utilized to investigate the immune microenvironment in DLBCL associated with H. pylori for novel biomarkers identification. A two-sample MR analysis confirmed a bidirectional causal relationship between H. pylori UREA antibody and DLBCL incidence. The primary method used (IVW: OR=1.323, 95 % CI 1.046-1.675, P-value=0.02<0.05) indicated a significant positive causal association without evidence of heterogeneity or horizontal pleiotropy. A total of 881 differentially expressed genes (DEGs) were identified when comparing DLBCL patients resistant versus sensitive to H. pylori eradication treatment from GSE182362. The hub genes EDNRB, ACTG2, SST, CCL2, COL11A1, SELE, ALB, DUOX2, BPIFB1, and CXCL6 exhibited enrichment within the immune microenvironment context. CCL2 exhibited significant correlations with M1 macrophages, M2 macrophages, Neutrophils, T cells CD4 memory resting and Plasma cells. These findings elucidate the causal association between H. pylori UREA antibody levels and DLBCL, while underscoring the potential for targeted therapy in H. pylori-positive patients diagnosed with DLBCL. - Source: PubMed
Publication date: 2026/03/04
Han ZesenJin MengpuHan PeisenWang FangChang DingyinChen XiujianZheng HuayuMeng Hongyu