Clinispin horizon 7SSVES Carrier caps
- Known as:
- Clinispin horizon 7SSVES Carrier caps
- Catalog number:
- WD4022
- Product Quantity:
- Each
- Category:
- -
- Supplier:
- Woodle
- Gene target:
- Clinispin horizon 7SSVES Carrier caps
Related genes to: Clinispin horizon 7SSVES Carrier caps
- Gene:
- CAPS NIH gene
- Name:
- calcyphosine
- Previous symbol:
- -
- Synonyms:
- CAPS1, MGC126562
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-31
- Date modifiied:
- 2016-07-18
Related products to: Clinispin horizon 7SSVES Carrier caps
(3-[CYCLOHEXYLAMINO]-1-PROPANE, SULPHONIC ACID) (CAPS BUFFER) extrapure(3-[CYCLOHEXYLAMINO]-1-PROPANE, SULPHONIC ACID) (CAPS BUFFER) extrapure.2ml 12-Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12-Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12-Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12-Well PCR Strip Tubes Strip Dome Caps Included.2ml 12-Well PCR Strip Tubes Strip Dome Caps Included.2ml 12-Well PCR Strip Tubes Strip Dome Caps Included.2ml 12-Well PCR Strip Tubes Strip Dome Caps Included.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Dome Caps Included, Sterile.2ml 12_Well PCR Strip Tubes Strip Dome Caps Included Related articles to: Clinispin horizon 7SSVES Carrier caps
- The order includes a range of zoonotic viruses, which can cause severe disease in humans. The viral replication machinery is a logical target for the development of direct-acting antivirals. Inhibition of the cap-snatching endonuclease activity of related influenza viruses provides a proof of concept. Using the influenza B virus (IBV) RNA-dependent RNA polymerase complex as a benchmark, we conducted a comparative analysis of endonuclease activities of recombinant full-length bunyaviral L proteins using gel-based assays. The IBV complex demonstrates specific endonucleolytic cleavage and a clear preference for capped substrates. In contrast, severe fever with thrombocytopenia syndrome, Sin Nombre, and Hantaan virus L proteins readily cleave capped and uncapped RNAs to a broader spectrum of RNA fragments. Active site mutants further help to control for the potential of contaminating nucleases, exonuclease activity, and RNA hydrolysis. The influenza cap-snatching inhibitor baloxavir and derivatives have been used to validate this approach. In conclusion, the results of this study demonstrate the importance of assays with single nucleotide resolution and the use of full-length L proteins as a valuable experimental tool to identify selective endonuclease inhibitors. - Source: PubMed
Publication date: 2025/03/14
Loutan Arlo JYang BaiuyanConnolly GabrielleMontoya AdamSmiley Robert JChatterjee Arnab KGötte Matthias - Translation regulation is essential to the survival of hosts. Most translation initiation falls under the control of the mTOR pathway, which regulates protein production from mono-methyl-guanosine (m7G) cap mRNAs. However, mTOR does not regulate all translation; hosts and viruses alike employ alternative pathways, protein factors, and internal ribosome entry sites to bypass mTOR. Trimethylguanosine (TMG)-caps arise from hypermethylation of pre-existing m7G-caps by the enzyme TGS1 and are modifications known for snoRNA, snRNA, and telomerase RNA. New findings originating from HIV-1 research reveal that TMG-caps are present on mRNA and license translation via an mTOR-independent pathway. Research has identified TMG-capping of selenoprotein mRNAs, junD, TGS1, DHX9, and retroviral transcripts. TMG-mediated translation may be a missing piece for understanding protein synthesis in cells with little mTOR activity, including HIV-infected resting T cells and nonproliferating cancer cells. Viruses display a nuanced interface with mTOR and have developed strategies that take advantage of the delicate interplay between these translation pathways. This review covers the current knowledge of the TMG-translation pathway. We discuss the intimate relationship between metabolism and translation and explore how this is exploited by HIV-1 in the context of CD4+ T cells. We postulate that co-opting both translation pathways provides a winning strategy for HIV-1 to dictate the sequential synthesis of its proteins and balance viral production with host cell survival. - Source: PubMed
Publication date: 2025/03/05
Boris-Lawrie KathleenLiebau JessicaHayir AbdullgadirHeng Xiao - Monogenic autoinflammatory uveitis belongs to the spectrum of monogenic autoinflammatory diseases. When early-onset uveitis is associated with specific extra-ocular manifestations, particularly in a familial or geographical context, it guides the clinician towards a diagnosis of a monogenic autoinflammatory disease. The clinical presentation and mode of inheritance will help identify the underlying cause, and the detection of a pathogenic variant will confirm the diagnosis and guide the management approach. In this review, we outline the main monogenic autoinflammatory uveitis conditions that clinicians should be aware of: Blau syndrome, ROSAH syndrome, cryopyrin-associated periodic syndromes (CAPS), partial mevalonate kinase deficiency, A20 haploinsufficiency, and NEMO syndrome. - Source: PubMed
Publication date: 2025/03/25
Lequain HippolyteKodjikian LaurentMeunier IsabelleJamilloux YvanSève Pascal - Substance use disorder (SUD) frequently co-occurs with posttraumatic stress disorder (PTSD). Feelings of shame and guilt are associated with either disorder but have not been studied in patients with both disorders. Index trauma characteristics are associated with PTSD severity and trauma-related shame. This study examines the effects of trauma-related guilt and shame, and index trauma on SUD and PTSD severity in a clinical sample of individuals with co-occurring SUD and PTSD. - Source: PubMed
Publication date: 2025/03/26
Faber Nathalie N MLortye Sera AMarquenie Loes AGoudriaan Anna EArntz Arnoudde Waal Marleen M - Practice assignments (i.e. homework) are a key component in cognitive behavioral therapies that predict treatment outcomes for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) separately. However, research has not explored these variables among individuals with comorbid PTSD and MDD. This study evaluated whether practice assignment adherence and helpfulness predicted PTSD (Clinician-Administered PTSD Scale for DSM-5; CAPS-5) and MDD (Montgomery-Åsberg Depression Rating Scale; MADRS) outcomes at posttreatment and 3-month follow-up. Data were derived from a randomized clinical trial comparing cognitive processing therapy (CPT) and behavioral activation-enhanced CPT (BA+CPT) among 83 U.S. active duty service members with comorbid PTSD and MDD. Participants reported greater assignment adherence in BA+CPT than CPT ( = .008), primarily due to higher adherence to BA assignments within BA+CPT. Multilevel models indicated helpfulness ratings were significantly related to decreased CAPS-5 scores ( = .044) but not MADRS scores ( = .074); service members with the highest helpfulness ratings achieved the best outcomes. Adherence was not significantly related to CAPS-5 ( = .494) or MADRS ( = .114) outcomes. Findings provide clinical insights regarding compliance in integrated treatments and highlight the value in assessing helpfulness of practice assignments during treatment. - Source: PubMed
Publication date: 2025/03/26
Walter Kristen HOtis Nicholas PKline Alexander CMiggantz Erin LHunt W MichaelGlassman Lisa H