Chimpanzee IL-6 ELISPOT kit, enzymatic staining
- Known as:
- Chimpanzee Interleukin-6 ELISPOT reagent, enzymatic staining
- Catalog number:
- ct174-pr5
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- U-CyTech biosciences
- Gene target:
- Chimpanzee IL-6 ELISPOT kit enzymatic staining
Related genes to: Chimpanzee IL-6 ELISPOT kit, enzymatic staining
- Gene:
- CEBPB NIH gene
- Name:
- CCAAT enhancer binding protein beta
- Previous symbol:
- TCF5
- Synonyms:
- LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-27
- Date modifiied:
- 2018-02-23
- Gene:
- CEBPD NIH gene
- Name:
- CCAAT enhancer binding protein delta
- Previous symbol:
- -
- Synonyms:
- CRP3, CELF, C/EBP-delta, NF-IL6-beta
- Chromosome:
- 8q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-24
- Date modifiied:
- 2018-02-23
- Gene:
- ENTPD6 NIH gene
- Name:
- ectonucleoside triphosphate diphosphohydrolase 6
- Previous symbol:
- CD39L2, IL6ST2
- Synonyms:
- NTPDase-6, dJ738P15.3
- Chromosome:
- 20p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-20
- Date modifiied:
- 2019-02-28
- Gene:
- IL6 NIH gene
- Name:
- interleukin 6
- Previous symbol:
- IFNB2
- Synonyms:
- IL-6, BSF2, HGF, HSF
- Chromosome:
- 7p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-12
- Gene:
- IL6RP1 NIH gene
- Name:
- interleukin 6 receptor pseudogene 1
- Previous symbol:
- IL6RL1
- Synonyms:
- -
- Chromosome:
- 9q22.2
- Locus Type:
- pseudogene
- Date approved:
- 1991-08-18
- Date modifiied:
- 2014-11-19
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- Acrylamide (ACR) is a hazardous chemical pollutant due to its thermal processing of certain foods. This study aimed to profile the metabolites of the methanolic extract of Cucurbita pepo L. (Cucurbitaceae) aerial parts against nephrotoxicity induced by ACR in rats. GC/MS and LC-ESI-MS/MS analysis were used for isolation and differentiation of different metabolites. In silico study was done on the identified triterpenes and sterols. In vivo nephrotoxicity was done by intraperitoneal injection of ACR to rats. Serum kidney function tests, oxidative stress, inflammatory markers and histopathological observation were evaluated. Twenty-four compounds were identified, where stigmasterol and β -sitosterol were the most prevalent metabolites. Fifty-one compounds in positive and negative modes were also identified. Four compounds were isolated; stigmasterol, β -sitosterol, p-coumaric and p-hydroxybenzoic. Cucurbitacin A 2-O-β-D-glucopyranoside and karaviloside XIII possessed anti-inflammatory and antioxidant effects by in silico study. Treatment with C. pepo L. aerial parts methanolic extract restored the levels creatinine (Cr), blood urea nitrogen (BUN), protein content, malondialdehyde (MDA), tumor necrosis factor- alpha (TNF-α), interleukin-6 (IL-6), superoxide dismutase (SOD) and glutathione (GSH). In conclusion, C. pepo L. leaves methanolic extract possessed curative effect against ACR toxicity due to its richness with different bioactive compounds. - Source: PubMed
Publication date: 2025/03/19
AbouZeid Enaam MElbatanony Marwa MAhmed Yomna RHamed Manal A - Ischemia and reperfusion does damage to tissues and causes the decline of organ function though the inflammatory cascade. Noteworthy, HMGB1 possess a crucial role in promoting progression of these effects in kidney. The study aimed at ascertaining the concrete mechanism of HMGB1 triggering inflammatory cascade in renal ischemia-reperfusion injury (IRI). - Source: PubMed
Publication date: 2025/03/18
Wei QianWang JiaZhang Jiong - To investigate the response of primary nasal epithelial cells (NECs) to novel alpha haemolytic Streptococcus and lactobacilli strains, isolated from the upper respiratory tract of children. - Source: PubMed
Publication date: 2025/03/19
Yarlagadda TejasriCarey AlisonBryan EmilyHuygens FlaviaYarlagadda PrasadMaresco-Pennisi DianeColeman AndreaCervin AndersSpann Kirsten - To explore the correlation between the level of serum interleukin-6 (IL-6) and the severity of infection in patients with diabetic foot (DF) and the auxiliary value of IL-6 in DF diagnosis, and aim to provide reference for clinical treatment. Based on the hospital medical record system and the laboratory system, a retrospective analysis with case-control study was conducted on the data of patients in Liyuan Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology from January 2020 to September 2024. A total of 377 patients' information was collected, including 31 cases in control group with 17 males and 14 females from 31 to 91 years old and a median age of 71, 63 cases in NDF group with 43 males and 20 females from 37 to 96 years old, with a median age of 71, and 283 patients in DF group with 197 males and 86 females from 36 to 96 years, with a median age of 67. According to classification of infection severity, paints in the group of diabetes with DF were divided into mild infection subgroup (72 cases), moderate infection subgroup (143 cases) and severe infection subgroup (68 cases). The results showed that there were no statistically significant differences in age and gender among the three groups in the study (=1.795/=2.81, >0.05). The non parametric test results showed that there were statistically significant differences in IL-6, C-reactive protein (CRP), procalcitonin (PCT), white blood cell (WBC) and glucose (GLU) among the three groups of patients (=12.480, 36.277, 12.432, 12.838, 18.334, <0.05). The pairwise comparison results showed that compared with the control group, the NDF group had higher levels of CRP, PCT and GLU (=20.259, 20.118, 20.056, <0.05), and the levels of IL-6, CRP, PCT and WBC(=14.934,14.933,14.829,14.934, <0.05) were higher in the DF group. Both of the differences were statistically significant. But the difference of IL-6, CRP, PCT, WBC and GLU between the NDF and DF group was not statistically significant(=1.202,0.622,0.737,1.036,1.899,). In DF group, there were statistically significant differences in IL-6, CRP, PCT, WBC, and GLU levels among patients in the three infection subgroups (=11.174, 15.136, 8.657, 8.348, 3.698, <0.05).Compared to the mild subgroup, the levels of IL-6, CRP, PCT, WBC and GLU were higher in the severe subgroup were higher(=111.789,237.066,74.683,83.203,15.328, <0.05) and the levels of IL-6, CRP, PCT in the moderate subgroup were higher (=6.877, 8.846, 5.183, <0.05). And both of the differences were statistically significant. But there was no statistically significant difference in WBC and GLU level between the mild and the moderate subgroup(=1.684, 1.039,). The severity of infection in diabetic foot patients was positively correlated with the IL-6 level (=1.033, 95%: 0.024-0.043, <0.05). ROC curve showed that AUC of IL-6 for diagnosis in diabetic foots were 0.635. And joint testing showed that the AUC of IL-6+CRP, IL-6+PCT and IL-6+WBC were 0.718, 0.621, and 0.638 respectively. In conclusion,the level of serum IL-6 may be positively correlated with the severity of infection in diabetic foot patients, which may have auxiliary diagnostic value in predicting diabetic foot infection. And it may provide a reference for the grading of infection severity in diabetic foot patients to gauging serum IL-6 level. - Source: PubMed
Li J YXiong LWang P YMa Q F - Osteoarthritis (OA) is a chronic and degenerative joint disease with a rising incidence worldwide. Current therapeutic approaches primarily focus on symptom relief through systemic administration, which raises safety concerns related to side effects and long-term use. In this context, the local administration of natural compounds with anti-inflammatory and anti-arthritic properties, such as β-Lapachone constitutes an interesting alternative. In this work, we prepared and characterized injectable thermosensitive hybrid hydrogels loaded with β-Lapachone. A comprehensive characterization of the hydrogel systems was performed, including micellar diameter, mechanical properties at different temperatures, the ability to control drug release and microstructure. The anti-inflammatory activity of the free drug, as well as that of the blank or loaded hydrogels was then evaluated ex vivo, using OA cartilage explants. Additionally, in vivo studies were carried out in a rabbit model of OA to assess their clinical potential. The results suggest that the hydrogel systems possess a composite microstructure integrating micelles, together with a temperature-responsive stiffness and the ability to modulate drug release. In addition, β-Lapachone-loaded hydrogels display an interesting immunomodulatory potential ex vivo, as they were able to efficiently reduce the secretion of several proinflammatory mediators, such as IL-6, MMP9, MMP13 and CXCL8. Furthermore, the drug-loaded hydrogels were found to improve in vivo cartilage and bone histomorphometric markers, such as subchondral bone thickness, as well as early signs of cartilage damage, such as the fibrillation index. Therefore, the developed β-Lapachone-loaded thermosensitive hydrogels constitute a promising alternative for OA management. - Source: PubMed
Publication date: 2025/03/17
Rouco HelenaPermuy MariaMuñoz FernandoVázquez José AntonioCaeiro José RLandin MarianaDiaz-Rodriguez Patricia