Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: PE
- Known as:
- Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: PE
- Catalog number:
- 235APE-100T
- Product Quantity:
- 100 test
- Category:
- -
- Supplier:
- Immunostep
- Gene target:
- Antibody: CD235a Clone: HI264 Isotype: IgG2a Conjugate:
Related genes to: Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: PE
- Gene:
- GYPA NIH gene
- Name:
- glycophorin A (MNS blood group)
- Previous symbol:
- MNS
- Synonyms:
- GPA, MN, CD235a
- Chromosome:
- 4q31.21
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: PE
Related articles to: Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: PE
- Ionizing radiation (IR) induces profound bone marrow (BM) injury by disrupting hematopoietic stem cell (HSC) homeostasis, leading to acute myelosuppression and long-term hematopoietic dysfunction. Although transcriptome-wide analyses have advanced our understanding of radiation responses, the key molecular networks and hub genes governing post-irradiation BM injury remain incompletely defined. - Source: PubMed
Publication date: 2026/03/27
Siregar Khalish Arsy Al KhairyLee Chi-HoKim Jong-JinChang Dong-JoJeong Seung-Hyun - Hemolytic disease of the fetus and newborn (HDFN) is a potentially life-threatening condition caused by maternal alloimmunization against fetal red blood cell (RBC) antigens. While most cases involve well-characterized antibodies such as anti-D, anti-c, or anti-K, antibodies against low-prevalence antigens (LPAs) - particularly those within the MNS blood group system - remain underrecognized and underreported. - Source: PubMed
Publication date: 2026/02/16
Gavillet MathildeGleich-Nagel TobiasLegardeur HeleneBaud DavidFriedrich NoemyHenny ChristineCanellini GiorgiaMaisonneuve EmelineLejon Crottet Sofia - Although serological and genetic studies of equine blood group systems have been conducted for many years, the molecular basis of erythrocyte antigens' variability has remained largely unexplored. In this study, we aimed to elucidate the genetic basis of serological variation within equine blood group K. Using mRNA extracted from peripheral blood samples (n = 100) collected from horses with known serological blood types (Ka or K-), we performed a transcriptome-wide association study (TWAS), which revealed a significantly associated region on equine chromosome 2 (ECA2). A detailed analysis of this region identified GYPA (glycophorin A) as the most promising candidate gene. Resequencing its entire coding sequence revealed the presence of a dinucleotide missense variant in exon 3 (ENSECAT00000026370.3:c.145_146delinsAT; p.Asp49Ile), which is predicted to potentially alter the function of the GYPA protein. Genotyping this variant in a large, breed-diverse cohort, which included family-based samples, confirmed perfect cosegregation between the identified GYPA missense substitution and serological K blood group typing results. Our findings demonstrate that blood transcriptome-based approaches, despite certain limitations, can effectively reveal the molecular basis of equine erythrocyte antigen variability. - Source: PubMed
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