Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: CF-BlueTM
- Known as:
- Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: CF-BlueTM
- Catalog number:
- 235ACFB-100T
- Product Quantity:
- 100 test
- Category:
- -
- Supplier:
- Immunostep
- Gene target:
- Antibody: CD235a Clone: HI264 Isotype: IgG2a Conjugate: CF-BlueTM
Related genes to: Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: CF-BlueTM
- Gene:
- GYPA NIH gene
- Name:
- glycophorin A (MNS blood group)
- Previous symbol:
- MNS
- Synonyms:
- GPA, MN, CD235a
- Chromosome:
- 4q31.21
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: CF-BlueTM
Related articles to: Antibody: CD235a, Clone: HI264 , Isotype: IgG2a, Conjugate: CF-BlueTM
- The antigens in the MNS blood group system, presented on glycophorin (GP), are regulated by the GYPA, GYPB, and GYPE genes. Some hybrid GP can express Mi antigen, the most common being GP.Mur. Of potential clinical significance in transfusion practice, GYP*Mur homozygotes can produce anti-JENU because they lack expression of the high-frequency JENU antigen. Although serological typing using anti-Mi is very likely to identify GP.Mur, this method cannot reliably distinguish the underlying GP or confirm the zygosity of GP.Mur, which is relevant for transfusion safety. We, therefore, developed and validated a polymerase chain reaction with high-resolution melting (PCR-HRM) assay for distinguishing homozygous GYP*Mur from heterozygous GYP*Mur/GYPB and homozygous GYPB genotypes. - Source: PubMed
Publication date: 2026/06/12
Khantisitthiporn OnruedeeNathalang OytipIntharanut KamphonChoychimplee Tanaporn - To reconstruct the forensic identification process following the 1994 explosion at the Duboki Jarak military ammunition and explosive ordnance storage facility in Croatia and to evaluate the role of early PCR-based DNA typing in the identification of severely fragmented human remains under wartime conditions. - Source: PubMed
Primorac DraganAnđelinović ŠimunGugić AnteStaničić Ivan MarioDefinis MarijaKružić IvanaJerković IvanBašić Željana - Ionizing radiation (IR) induces profound bone marrow (BM) injury by disrupting hematopoietic stem cell (HSC) homeostasis, leading to acute myelosuppression and long-term hematopoietic dysfunction. Although transcriptome-wide analyses have advanced our understanding of radiation responses, the key molecular networks and hub genes governing post-irradiation BM injury remain incompletely defined. - Source: PubMed
Publication date: 2026/03/27
Siregar Khalish Arsy Al KhairyLee Chi-HoKim Jong-JinChang Dong-JoJeong Seung-Hyun - Hemolytic disease of the fetus and newborn (HDFN) is a potentially life-threatening condition caused by maternal alloimmunization against fetal red blood cell (RBC) antigens. While most cases involve well-characterized antibodies such as anti-D, anti-c, or anti-K, antibodies against low-prevalence antigens (LPAs) - particularly those within the MNS blood group system - remain underrecognized and underreported. - Source: PubMed
Publication date: 2026/02/16
Gavillet MathildeGleich-Nagel TobiasLegardeur HeleneBaud DavidFriedrich NoemyHenny ChristineCanellini GiorgiaMaisonneuve EmelineLejon Crottet Sofia - Although serological and genetic studies of equine blood group systems have been conducted for many years, the molecular basis of erythrocyte antigens' variability has remained largely unexplored. In this study, we aimed to elucidate the genetic basis of serological variation within equine blood group K. Using mRNA extracted from peripheral blood samples (n = 100) collected from horses with known serological blood types (Ka or K-), we performed a transcriptome-wide association study (TWAS), which revealed a significantly associated region on equine chromosome 2 (ECA2). A detailed analysis of this region identified GYPA (glycophorin A) as the most promising candidate gene. Resequencing its entire coding sequence revealed the presence of a dinucleotide missense variant in exon 3 (ENSECAT00000026370.3:c.145_146delinsAT; p.Asp49Ile), which is predicted to potentially alter the function of the GYPA protein. Genotyping this variant in a large, breed-diverse cohort, which included family-based samples, confirmed perfect cosegregation between the identified GYPA missense substitution and serological K blood group typing results. Our findings demonstrate that blood transcriptome-based approaches, despite certain limitations, can effectively reveal the molecular basis of equine erythrocyte antigen variability. - Source: PubMed
Mackowski MariuszKajdasz ArkadiuszLaskowska KajaCieslak Jakub