Antibody: CD11c, Clone: BU-15 , Isotype: IgG1, Conjugate: PerCP
- Known as:
- Antibody: CD11c, Clone: BU-15 , Isotype: IgG1, Conjugate: PerCP
- Catalog number:
- 11CPP3-100T
- Product Quantity:
- 100 test
- Category:
- -
- Supplier:
- Immunostep
- Gene target:
- Antibody: CD11c Clone: BU-15 Isotype: IgG1 Conjugate: PerCP
Related genes to: Antibody: CD11c, Clone: BU-15 , Isotype: IgG1, Conjugate: PerCP
- Gene:
- ITGAX NIH gene
- Name:
- integrin subunit alpha X
- Previous symbol:
- CD11C
- Synonyms:
- CD11c
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-15
- Date modifiied:
- 2015-12-15
Related products to: Antibody: CD11c, Clone: BU-15 , Isotype: IgG1, Conjugate: PerCP
Related articles to: Antibody: CD11c, Clone: BU-15 , Isotype: IgG1, Conjugate: PerCP
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Alamholo MostafaTarinejad Alireza - Mesenchymal stromal cells from equine ovarian follicular aspirates represent a promising source for cell-based therapies. However, the age of the donor mare may alter their biological properties and therapeutic potential. This study aimed to evaluate the effect of age on MSCs from ovarian follicular aspirates of young (< 10 years, n = 5) and aged (≥ 18 years, n = 5) mares. MSCs were isolated, expanded, cryopreserved at passage 3, and subsequently thawed to evaluate proliferation, immunophenotype, differentiation capacity, and gene expression profiles. Proliferation rates, total cell yield, and mean time to reach 80% confluence showed no significant differences between the age groups. Flow cytometry analysis confirmed uniform expression of MSC-associated positive markers (CD90, CD29) and absence of CD45, CD19 and MHC-II in both groups. Trilineage differentiation assays demonstrated that cells retained trilineage differentiation capacity at a qualitative level regardless of donor age. However, transcriptomic analysis using RT Profiler PCR Array and qPCR validation revealed substantial differences in gene expression. MSCs from young mares exhibited significant upregulation (fold change ≥ 2; p < 0.05) of stemness-related genes (LIF, POU5F2), regulators of adipogenic and chondrogenic differentiation (PPARγ, SOX9), and cell migration-associated markers (MCAM, VCAM). Conversely, MSCs from young mares showed decreased expression (fold change ≤ 0.5; p < 0.05) of lineage-specific differentiation genes (TBX5, SLC2A4), inflammatory mediators (IL6), and senescence-associated markers (ITGAX, BMP4, SMAD3). These findings suggest that, although some MSC characteristics are preserved, donor age significantly alters the transcriptomic profile of equine follicular MSCs, which could affect their therapeutic efficacy. - Source: PubMed
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Muñoz-García C CSoriano-Campos M PLuis-Calero MGallardo-Soler AGonzález-Fernández LMacías-García B - Kidney stones are a globally prevalent condition, but their pathogenesis remains incompletely understood. This study aimed to identify and validate key genes implicated in kidney stone formation through sequencing data analysis, offering novel molecular targets for elucidating the underlying pathogenic mechanisms. - Source: PubMed
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