Antibody: CD117, Clone: 104D2 , Isotype: IgG1, Conjugate: PE
- Known as:
- Antibody: CD117, Clone: 104D2 , Isotype: IgG1, Conjugate: PE
- Catalog number:
- 117PE-100T
- Product Quantity:
- 100 test
- Category:
- -
- Supplier:
- Immunostep
- Gene target:
- Antibody: CD117 Clone: 104D2 Isotype: IgG1 Conjugate:
Related genes to: Antibody: CD117, Clone: 104D2 , Isotype: IgG1, Conjugate: PE
- Gene:
- KIT NIH gene
- Name:
- KIT proto-oncogene, receptor tyrosine kinase
- Previous symbol:
- PBT
- Synonyms:
- CD117, SCFR, C-Kit
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: Antibody: CD117, Clone: 104D2 , Isotype: IgG1, Conjugate: PE
Related articles to: Antibody: CD117, Clone: 104D2 , Isotype: IgG1, Conjugate: PE
- Periodontitis adversely affects oral and overall health. Bone marrow-derived mesenchymal stem cells (BMMSCs) play regulatory roles in the immune system, and the exploration of therapeutic strategies involving BMMSCs has garnered significant attention in the context of inflammatory pathological processes. Interleukin-6 can regulate microRNA expression by activating the signal transducer and activator of transcription 3 (STAT3) and functions in some systemic diseases. Notably, the regulatory mechanisms between IL-6 and miR-181a-5p in BMMSCs underlying periodontitis are still unknown. This study aims to uncover the regulatory mechanisms between IL-6 and miR-181a-5p and create a new treatment strategy for periodontal tissue regeneration. - Source: PubMed
Publication date: 2026/06/11
Wu SiWang JieYang Deqin - Radiotherapy (RT) is the most common nonsurgical treatment for head and neck squamous cell carcinoma (HNSCC), while HNSCC was insensitive to RT, which is the primary cause of treatment failure. Thus, exploring the novel molecular mechanisms of HNSCC progression may help to increase tumor radiosensitivity. Previous studies have revealed the induction of apoptosis in anti-tumor treatment with oleuropein; while the effect of oleuropein on pyroptosis is unclear. This study explored the effect of oleuropein on HNSCC and the underlying mechanisms in HNSCC cells and HNSCC mice. HNSCC cells were exposed to central irradiation at 5 Gy with 6MV-X-ray to mimic cell RT, and HNSCC mice received a dose of 12 Gy on days 7 and 14 to mimic the in vivo RT. Cell proliferation and apoptosis were assessed via cell counting Kit-8 assay and flow cytometry; RNA expression and protein levels were detected via quantitative real time-polymerase chain reaction (PCR) and western blotting; gasdermin E (GSDME) promoter methylation level was assessed by Methylation-specific PCR and MassARRAY assay; tumor growth and death were assessed via Ki67 immunohistochemical staining and terminal deoxynucleotidyl Transferase Mediated Nick End Labeling staining; pathological changes in tumor tissues was assessed via hematoxylin-eosin staining. The results showed that oleuropein inhibited cell proliferation and enhanced radiosensitivity by inducing caspase3/GSDME-N-dependent pyroptosis in HNSCC cells. Additionally, oleuropein up-regulated miR-194-5p expression and miR-194-5p inhibitor reversed the suppression of cell proliferation induced by oleuropein. Mechanistically, miR-194-5p targeted DNMT3A to affect GSDME promoter methylation, thereby regulating GSDME expression to affect pyroptosis. In vivo experiments further demonstrated that oleuropein blocked tumor growth and enhanced radiosensitivity in HNSCC. In conclusion, these results provide an experimental basis for the application of oleuropein in HNSCC treatment. - Source: PubMed
Publication date: 2026/06/11
Xu TingChen Gaoxiang - The objective of this study was to investigate the effects of alginate oligosaccharides on wound cell proliferation, migration, apoptosis, macrophage polarisation, and wound healing. The results of the Cell Counting Kit-8, Transwell method, and caspase-3 immunofluorescence showed that alginate oligosaccharides effectively promoted keratinocyte proliferation, migration, and reduced apoptosis by activating the PI3K/AKT1 signalling pathway. The polarisation of macrophages was detected using iNOS and Arg-1 immunofluorescence. Alginate oligosaccharides induced M2 polarisation. This was negated after using an AKT1 inhibitor. In vitro cell experiments showed that alginate oligosaccharides did not affect macrophage proliferation but showed a significant reduction in macrophage numbers in in vivo animal wound models, accompanied by a trend in M2 polarisation. Although AOs had no direct in vitro antibacterial effect, their in vivo application modulated the composition of wound microbiota, which may be related to AOs induced macrophage M2 polarization and the improvement of local inflammatory response. The combined effects of alginate oligosaccharides on keratinocytes and macrophages ultimately promoted wound healing and altered microbiota composition, thereby providing a new, potential treatment option for wound healing(Fig. 1). - Source: PubMed
Publication date: 2026/06/11
Liu LeiPan BohanTao ZihanZhu ShihuiLiu QingsongJin Jian - This study presents a comprehensive SCAPS-1D simulation of an ultra-thin CIGSe/CdS/i-ZnO/ITO solar cell with a 420 nm absorber layer, focusing on the influence of key physical parameters and back surface field engineering. The effects of acceptor doping density in CIGSe ( = 10 to 10 cm), interface defect density ( = 10 to 10 cm), bulk defect density ( = 10 to 10 cm), and electron affinity ( = 4.35-4.65 eV) were systematically investigated. Increasing significantly enhanced device performance by strengthening the internal electric field and increasing the carrier concentration, thereby improving , fill factor, and efficiency. In contrast, elevated interface and bulk defect densities led to severe recombination losses and significant degradation of all photovoltaic parameters. Optimal band alignment was obtained at ≈ 4.35 eV, corresponding to a slight negative conduction-band offset that facilitates carrier transport and suppresses recombination. Recombination analysis showed stable performance of the radiative recombination coefficient over the range 10 to 10 cm s, while Auger recombination became dominant at coefficients above 10 cm s. Among the investigated back surface field layers, CuO provided the best performance due to its wide band gap (2.2 eV) and strong back-surface electric field, yielding a maximum simulated efficiency of ∼40.3% with = 0.817 V, = 30.03 mA cm, and FF = 82.88%. Capacitance-voltage and Mott-Schottky analyses revealed that capacitance increases from 57.6 to 109.9 nF cm with increasing , and the built-in potential ranges from 0.80 to 1.32 V, confirming enhanced junction properties. These results provide practical guidelines for optimizing ultra-thin CIGSe solar cells through defect control, band alignment tuning, and back surface field design. - Source: PubMed
Publication date: 2026/06/08
Gezgin Serap YiğitBasyooni-M Kabatas M AKiliç Hamdi Şükür - The rapid discovery of functional coatings is vital for advancing technologies in healthcare, energy, and environmental protection, yet it remains limited by the lack of scalable high-throughput (HT) methods. Here, an ultra-high-throughput (UHT) combinatorial strategy is introduced for the miniaturized synthesis and screening of polyamine-polyphenolic (PaPp) coatings (formed in Tris buffer) using droplet microarrays (DMA). Approximately 30 000 coatings were generated from binary and ternary combinations of 51 polyphenols (Pp) and 12 polyamines (Pa), each produced in 160 nL volumes (<5 mL total reagent use), enabling the rapid identification of hundreds of previously unknown functional materials, including over 225 fluorescent coatings and more than 100 redox-active, metal-reducing surfaces. Antibacterial screening uncovered seven coatings with reproducible activity against Pseudomonas aeruginosa, and subsequent validation on macroscale substrates confirmed up to <1-log colony-forming unit (CFU) reduction against P. aeruginosa and E. coli. Importantly, five coatings exhibited multiple functionalities, combining surface stability, intrinsic fluorescence, metal-reducing activity, antibacterial effects, and compatibility with adherent human cells. This UHT approach yields the first comprehensive functionality map of PaPp coatings, revealing previously inaccessible multifunctional materials and demonstrating a scalable strategy for the discovery of surface chemistries with tailored optical, redox, and biological properties. - Source: PubMed
Publication date: 2026/06/11
Widyaya Vania TandaGómez Joaquín E UrrutiaReuß PaulWelle AlexanderGattung Rolf AMayer JanaKrolla PeterReischl MarkusFriederich PascalPopova Anna ASchwartz ThomasLevkin Pavel A