Polyclonal Rabbit C14orf49 Antibody
- Known as:
- Polyclonal Rabbit C14orf49 Antibody
- Catalog number:
- KA0471
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit C14orf49 Antibody
Related genes to: Polyclonal Rabbit C14orf49 Antibody
- Gene:
- SYNE3 NIH gene
- Name:
- spectrin repeat containing nuclear envelope family member 3
- Previous symbol:
- C14orf49, LINC00341, C14orf139, NCRNA00341
- Synonyms:
- FLJ25605, NET53, Nesprin-3, Nesp3
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-27
- Date modifiied:
- 2016-11-18
Related products to: Polyclonal Rabbit C14orf49 Antibody
Related articles to: Polyclonal Rabbit C14orf49 Antibody
- Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are classified into low grade (LG), high grade (HG), and invasive carcinoma-associated (IC) groups, each requiring different clinical therapeutic strategies. Loss of planar nuclear polarity (PNP) in IPMNs is a key factor in tumor progression. We studied 29 IPMN cases (8 LG, 10 HG, and 11 IC) using targeted next-generation sequencing and immunohistochemistry to elucidate the complex molecular dynamics of PNP factors in tumor progression. We analyzed the mRNA expression of 61 PNP-related factors, including those associated with the cell membrane, epithelial-mesenchymal transition (EMT), the Hippo pathway, cytoskeletal network, and nuclear envelope, in the IPMN cases. The Kruskal-Wallis test identified 15 PNP factors (ITGB1, CLDN4, CLDN7, ANO1, TWIST1, SRSF1, LATS2, TOP2A, MAPK1, TGFBR1, PCNT, FSCN1, RHOA, CDC42, and SYNE3) with significantly higher mRNA expression in IC compared with LG and HG. Multinomial logistic regression identified three PNP factors (CLDN7, FSCN1, and TOP2A) with significantly higher mRNA expression and stronger or more frequent immunohistochemical positivity in both LG versus IC and LG versus HG comparisons. Overall, our study indicates that the molecular mechanisms underlying disturbed PNP in IPMNs are not mediated by a single pathway but involve multiple interconnected pathways. Our findings may contribute to elucidation of the molecular mechanisms regulating PNP in IPMNs, enhancing our understanding of tumor progression and contributing to more accurate pathological diagnosis. - Source: PubMed
Publication date: 2026/03/28
Tamura TakaakiMatsuzaki IbuMusangile Fidèle YambayambaTakahashi YuichiItonaga MasahiroAshida ReikoKojima FumiyoshiKitano MasayukiMurata Shin-Ichi - To detect the expression of Spectrin Repeat Containing Nuclear Envelope Family Member 3 (SYNE3) and Cluster of Differentiation 34 (CD34) in non-small cell lung cancer (NSCLC). It also aimed to explore the relationship between SYNE3 and NSCLC angiogenesis and clinicopathologic features to identify new biomarkers for NSCLC. - Source: PubMed
Publication date: 2024/09/15
Wu YunxiChen DeheLuo YuWang JunGong HaiyingLi JunhuaJiang Li - Carotid artery intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and the identification of additional susceptibility loci furthers our knowledge on the genetic architecture underlying atherosclerosis. - Source: PubMed
Publication date: 2021/12/02
Yeung Ming WaiWang Siqivan de Vegte Yordi JBorisov Olegvan Setten JessicaSnieder HaroldVerweij NiekSaid M Abdullahvan der Harst Pim - Acephalic spermatozoa syndrome (ASS) is a rare teratozoospermia that leads to male infertility. Previous work suggested a genetic origin. Variants of Sad1 and UNC84 domain containing 5 (SUN5) are the main genetic cause of ASS; however, its pathogenesis remains unclear. Here, we performed whole-exome sequencing in 10 unrelated ASS and identified 2 homozygous variants, c.381delA[p.V128Sfs7*] and c.675C>A[p.Y225X], and 1 compound variant, c.88 C > T[p.R30X] and c.381 delA [p.V128Sfs7*], in SUN5 in 4 patients. The c.381delA variant had been identified as pathogenic in previous reports, while c.675C>A and c.88 C > T were two novel variants which could lead to a premature termination codon (PTC) and resulted in loss of SUN5, and may also be pathogenic. SUN5 mRNA and protein were present at very low levels in ASS patients with SUN5 nonsense mutation. Furthermore, the distribution of outer dense fiber protein 1 (ODF1) and Nesprin3 was altered in sperm of ASS patients with SUN5 variants. The co-immunoprecipitation analysis indicated that SUN5 and ODF1, SUN5 and Nesprin3, and ODF1 and Nesprin3 interacted with each other in transfected HEK293T cells. Thus, we propose that SUN5, Nesprin3, and ODF1 may form a 'triplet' structure through interactions at neck of sperm. When gene variants resulted in a loss of SUN5, the 'triplet' structure disappears and then the head-tail junction becomes fragile, leading to the occurrence of ASS. - Source: PubMed
Zhang DuoHuang Wu-JianChen Guo-YongDong Li-HongTang YingZhang HuiLi Qing-QinMei Xiao-YanWang Zhi-HongLan Feng-Hua - Linker of nucleoskeleton and cytoskeleton (LINC) complexes are molecular tethers that span the nuclear envelope (NE) and physically connect the nucleus to the cytoskeleton. They transmit mechanical force across the NE in processes such as nuclear anchorage, nuclear migration, and homologous chromosome pairing during meiosis. LINC complexes are composed of KASH proteins traversing the outer nuclear membrane, and SUN proteins crossing the inner nuclear membrane. Humans have several SUN- and KASH-containing proteins, yet what governs their proper engagement is poorly understood. To investigate this question, we solved high resolution crystal structures of human SUN2 in complex with the KASH-peptides of Nesprin3, Nesprin4, and KASH5. In comparison to the published structures of SUN2-KASH1/2 we observe alternative binding modes for these KASH peptides. While the core interactions between SUN and the C-terminal residues of the KASH peptide are similar in all five complexes, the extended KASH-peptide adopts at least two different conformations. The much-improved resolution allows for a more detailed analysis of other elements critical for KASH interaction, including the KASH-lid and the cation loop, and a possible self-locked state for unbound SUN. In summary, we observe distinct differences between the examined SUN-KASH complexes. These differences may have an important role in regulating the SUN-KASH network. - Source: PubMed
Publication date: 2020/10/12
Cruz Victor EEsra Demircioglu FSchwartz Thomas U